What is NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis?
Idiopathic cutaneous and mucosal candidosis (also called idiopathic chronic mucocutaneous candidiasis, or CMCC) is a condition where the body cannot properly fight off infections caused by Candida, a type of yeast (fungus) that normally lives on the skin and inside the body without causing harm. In people with this condition, Candida grows out of control and causes persistent, recurring infections on the skin, nails, and the moist linings of the body such as the mouth, throat, and genitals. Unlike typical yeast infections that clear up quickly with treatment, these infections keep coming back or never fully go away. The condition is called 'idiopathic' when no clear underlying cause — such as HIV infection, diabetes, or immune-suppressing medications — can be found. It is thought to involve a problem with how the immune system recognizes and fights Candida specifically. Some cases are linked to genetic changes that affect immune function, while others have no identified cause. Symptoms can range from mild to severe and often have a big impact on quality of life. The mouth, nails, and skin are most commonly affected. Treatment usually involves long-term antifungal medicines, but the infections tend to return when treatment stops. Research is ongoing to better understand the immune defects involved and to develop more targeted therapies.
Key symptoms:
Recurring or persistent yeast (Candida) infections in the mouth (thrush)Thick, discolored, or damaged nails due to fungal infectionSkin rashes or thickened skin patches caused by CandidaInfections in the throat or esophagus making swallowing uncomfortableGenital yeast infections that keep coming backCracking or soreness at the corners of the mouthWhite patches inside the mouth that are hard to wipe awayScalp infections caused by CandidaNail loss or nail deformity over timeGeneral discomfort and pain in affected areas
- Inheritance
- Variable
- Can be inherited in different ways depending on the underlying gene
- Age of Onset
- Variable
- Can begin at different ages, from infancy through adulthood
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis.
View clinical trials →Clinical Trials
View all trials with filters →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
No actively recruiting trials found for NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis.
Community
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Start the conversation →Latest news about NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis.
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Caregiver Resources
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Questions for your doctor
Bring these to your next appointment
- Q1.What is causing my immune system to struggle with Candida specifically?,Should I have genetic testing, and which genes should be tested?,How long will I need to take antifungal medication, and what happens if I stop?,What are the signs that the antifungal medicine is no longer working, and what are my options then?,Should I be checked for related conditions like thyroid or adrenal gland problems?,Are there any newer or experimental treatments I should know about?,What should I do if I develop a fever or feel very unwell — is there an emergency plan I should have?
Common questions about NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis
What is NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis?
Idiopathic cutaneous and mucosal candidosis (also called idiopathic chronic mucocutaneous candidiasis, or CMCC) is a condition where the body cannot properly fight off infections caused by Candida, a type of yeast (fungus) that normally lives on the skin and inside the body without causing harm. In people with this condition, Candida grows out of control and causes persistent, recurring infections on the skin, nails, and the moist linings of the body such as the mouth, throat, and genitals. Unlike typical yeast infections that clear up quickly with treatment, these infections keep coming back
Frequently asked questions about NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis?
NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:35066). It is typically inherited as variable. Age of onset is generally variable. For verified primary sources, see the UniteRare NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis page.
How is NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis inherited?
NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis follows variable inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis?
Approved treatments for NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials for NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis?
Active clinical trials for NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis are tracked daily from ClinicalTrials.gov. Trial availability changes frequently; check the UniteRare trial listings for the current count and recruitment status. Sponsors of rare-disease research often welcome inquiries even when a trial is not actively recruiting at a given moment.
How do I find a specialist for NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis?
Verified NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full NON RARE IN EUROPE: Idiopathic cutaneous and mucosal candidosis page for complete clinical details, sources, and verified-specialist listings.
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