NarcolepsyNews & Research
11 curated articles for Narcolepsy — FDA updates, peer-reviewed research, clinical-trial milestones, and sponsor press releases. Sorted newest-first.
- Behavioral sleep medicine May 4, 2026
" My Partner Just Wants to Sleep ": A Qualitative Study of the Experience of Living with a Partner with Narcolepsy or Idiopathic Hypersomnia.
Narcolepsy and Idiopathic Hypersomnia (IH) are chronic sleep disorders that negatively impact the Health-Related Quality of Life (HRQoL) of those who are diagnosed with the disorders. As such, Narcolepsy and IH may also impact the HRQoL of those close to the patient (e.g. partners, parents). This pr...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
- Physiology (Bethesda, Md.) May 4, 2026
The impact of antigen presentation on BBB disruption and neuroinflammation.
Blood brain barrier (BBB) disruption is a potentially deadly complication of numerous neurological diseases as diverse as cerebral malaria, dengue hemorrhagic fever, tauopathies, multiple sclerosis, schizophrenia, Parkinson's disease, narcolepsy, and COVID-19. Neuroinflammation and immune cell infil...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
- Children (Basel, Switzerland) May 4, 2026
Sleep and Cytokines: A Bidirectional Dialogue Involving Rest and Immunity.
Sleep is a cardinal biological process that backstops central nervous system function, which also plays a crucial role in regulating systemic homeostasis, including immune activities. Cytokines, particularly interleukin-1β and tumor necrosis factor-α, act as mediators bridging sleep and ...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
- Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine May 4, 2026
Mortality in narcolepsy and other sleep clinic patients: a 25-year propensity-matched VA cohort study.
Prior research shows increased mortality in patients with narcolepsy compared to the general population; overall, the evidence remains highly controversial and comparative data with general sleep clinic populations remains limited. We examined mortality and healthcare utilization among patients with...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
- Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine Apr 27, 2026
Cardiovascular risk in narcolepsy: Comparison of type 1 and type 2 in a real-world cohort.
To compare the differences in the risk of cardiovascular disease (CVD) events between narcolepsy type 1 (NT1) and type 2 (NT2) among patients with narcolepsy, while accounting for real-world use of stimulants. Using the 2005-2023 MarketScan Commercial and Medicare Supplemental databases, we identifi...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
- Sleep medicine Apr 26, 2026
The hidden burden of narcolepsy type 1: Discordance in psychobehavioral symptoms between patient self-reports and reports from close family members and friends.
Narcolepsy type 1 (NT1) is increasingly recognized as a multidimensional disorder in which psychiatric and psychosocial difficulties contribute to disability. Yet little is known about how these difficulties are perceived by patients compared with close informants. This study examined discrepancies ...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
- Sleep medicine Apr 25, 2026
Classification of narcolepsy type 1 using machine learning on Stanford Cataplexy Questionnaire responses and HLA-DQB1∗06:02.
Narcolepsy type 1 (NT1) is characterized by sleepiness, disturbed sleep, and cataplexy-episodes of sudden muscle tone loss triggered by emotions. Accurate diagnosis in large-scale studies remains challenging due to NT1's low prevalence and reliance on polysomnography. Prior studies have shown that c...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
- Frontiers in psychiatry Apr 21, 2026
Narcolepsy as an immune-associated hypothalamic encephalopathy: orexin dysfunction and implications for precision sleep medicine.
Narcolepsy can no longer be adequately conceptualized by excessive sleepiness and cataplexy. It is increasingly recognized as a multisystem hypothalamic encephalopathy, rooted in the selective loss or dysfunction of orexin neurons, yet extending across motor, psychiatric, metabolic, and autonomic do...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
- Sleep Mar 31, 2026
Hypothalamic volume reduction in adult patients with Narcolepsy type 1.
Narcolepsy-type 1 (NT1) is a neurological sleep disorder, characterized by a loss of orexin-producing cells in the posterior hypothalamus. These neurons are approximately 70,000 but have large orexin-containing projections within the hypothalamus and other brain areas. Several evidences suggest an a...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
- Journal of sleep research Mar 20, 2026
Facial Emotion Recognition in Children With Narcolepsy Type 1.
Narcolepsy type 1 is a neurological disorder typically emerging in childhood or adolescence, characterised by excessive daytime sleepiness, cataplexy and rapid eye movement sleep-related symptoms. Beyond its core features, increasing evidence suggests an impact on socio-cognitive development, includ...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
- Sleep Feb 9, 2026
Characteristics of maintenance of wakefulness test in drug-naïve patients with narcolepsy type 1 and type 2, and relationship with other measures of sleepiness.
We aimed to describe the characteristics of standard maintenance of wakefulness test (MWT), outside of clinical trials, in a sample of drug-naïve patients with narcolepsy type 1 (NT1) and type 2 (NT2). Consecutive drug-naïve patients with narcolepsy underwent two days of continuous PSG rec...
Why it matters: Recent peer-reviewed research on Narcolepsy that may be relevant for patients and caregivers.
More on Narcolepsy
Articles aggregated from peer-reviewed journals (PubMed), sponsor press releases, SEC 8-K filings, and FDA announcements. Original-source links are preserved on each article page. Editorial tags (Breaking / Notable / Update) reflect UniteRare's curation-time priority assessment.