Narcolepsy

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ORPHA:619284
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4FDA treatments15Active trials46Specialists8Treatment centers3Financial resources

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Also known as:

Narcolepsy with or without cataplexy
Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Apr 2026A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2

Alkermes, Inc. — PHASE3

TrialNOT YET RECRUITING
Apr 2026Decreasing Nightmares in Adults With Narcolepsy

University of Utah — NA

TrialNOT YET RECRUITING
Mar 2026A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy

Eisai Inc. — PHASE2

TrialNOT YET RECRUITING
Mar 2026A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1

Alkermes, Inc. — PHASE3

TrialNOT YET RECRUITING
Feb 2026Pain Assessment in Patients With Idiopathic REM Sleep Behaviour Disorder

University Hospital, Toulouse — NA

TrialRECRUITING
Jan 2026A Trial of TAK-861 for the Treatment of Narcolepsy With Cataplexy

Takeda — PHASE3

TrialRECRUITING
Dec 2025Epidemiology of Narcolepsy Type 1 and Type 2 in Spain

Takeda

TrialRECRUITING
Oct 2025Extended-release Sodium Oxybate in Children

Stanford University — PHASE2

TrialRECRUITING
May 2025A Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP441 Compared With Placebo in Participants With Narcolepsy Type 1

Jazz Pharmaceuticals — PHASE1

TrialRECRUITING
May 2025A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)

Takeda — PHASE2

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

4 available

Lumryz

sodium oxybate· Flamel Ireland Limited dba Avadel Ireland■ Boxed WarningOrphan Drug

treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy

View Details →FDA Label ↗Copay Card ↗Patient Assistance ↗

WAKIX

Pitolisant· Harmony Biosciences Management, Inc.Orphan Drug

treatment of excessive daytime sleepiness (EDS) or cataplexy in adult patients with narcolepsy and treatment of EDS in pediatric patients 6 years of age and older with narcolepsy

View Details →FDA Label ↗

Xywav

calcium, magnesium, potassium, and sodium oxybates· Jazz Pharmaceuticals Ireland Limited■ Boxed WarningOrphan Drug

XYWAV is indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy.

View Details →FDA Label ↗Copay Card ↗Patient Assistance ↗

Sunosi

Solriamfetol· Axsome Malta, Ltd.Orphan Drug

SUNOSI is indicated to improve wakefulness in adult patients with excessive daytime sleepiness associated with narcolepsy

View Details →FDA Label ↗Copay Card ↗Patient Assistance ↗

Clinical Trials

15 recruitingView all trials with filters →
Phase 31 trial
A Trial of TAK-861 for the Treatment of Narcolepsy With Cataplexy
Phase 3
Actively Recruiting
PI: Study Director (Takeda) · Sites: Redwood City, California; Brandon, Florida +5 more · Age: 16–70 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase 22 trials
A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)
Phase 2
Actively Recruiting
PI: Study Director (Takeda) · Sites: Redwood City, California; Santa Ana, California +28 more · Age: 18–70 yrs
View on ClinicalTrials.gov ↗I'm interested →
Extended-release Sodium Oxybate in Children
Phase 2
Actively Recruiting
PI: Oliver Sum-Ping, MD (Stanford University) · Sites: Redwood City, California · Age: 7–17 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase 11 trial
A Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP441 Compared With Placebo in Participants With Narcolepsy Type 1
Phase 1
Actively Recruiting
PI: Global Medical Lead (Jazz Pharmaceuticals) · Sites: Atlanta, Georgia; Cincinnati, Ohio +2 more · Age: 18–64 yrs
View on ClinicalTrials.gov ↗I'm interested →
N/A2 trials
The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders
N/A
Actively Recruiting
· Sites: Suzhou, Jiangsu · Age: 8–75 yrs
View on ClinicalTrials.gov ↗I'm interested →
Pain Assessment in Patients With Idiopathic REM Sleep Behaviour Disorder
N/A
Actively Recruiting
· Sites: Toulouse · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Other8 trials
WAKIX® (Pitolisant) Pregnancy Registry
Actively Recruiting
· Sites: Morrisville, North Carolina
View on ClinicalTrials.gov ↗I'm interested →
Child and Adolescent Registry for Participants With Narcolepsy
Actively Recruiting
· Sites: Phoenix, Arizona; Tucson, Arizona +23 more · Age: 0–17 yrs
View on ClinicalTrials.gov ↗I'm interested →
Study of Psychological, Sociological and Professional Factors Associated With Maintenance of Wakefulness Test
Actively Recruiting
· Sites: Lyon · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
SUNOSI® (Solriamfetol) Pregnancy Registry
Actively Recruiting
· Sites: Morrisville, North Carolina; Wilmington, North Carolina
View on ClinicalTrials.gov ↗I'm interested →
Proteomics and Metabolomics of Body Fluid in Patients With Narcolepsy
Actively Recruiting
· Sites: Jinan, Shandong · Age: 5–100 yrs
View on ClinicalTrials.gov ↗I'm interested →
Mentalizating in Adults Suffering from Narcolepsy Type 1.
Actively Recruiting
PI: Rachel DEBS, MD (Centre de compétence Narcolepsies et Hypersomnies ) · Sites: Toulouse · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Bacterial Translocation and Gut Microbiota in Type 1 Narcolepsy Patients Versus a Control Population
Actively Recruiting
PI: Catherine Dunyach-Remy (CHU de Nimes) · Sites: Nîmes, Gard; Montpellier · Age: 10–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Epidemiology of Narcolepsy Type 1 and Type 2 in Spain
Actively Recruiting
PI: Study Director (Takeda) · Sites: Castellon, Castellon; Pamplona, Navarre +8 more
View on ClinicalTrials.gov ↗I'm interested →

Specialists

Showing 25 of 46View all specialists →
GP
Giuseppe Plazzi
Specialist
PI on 1 active trial
GM
Grace Wang, MD
Specialist
PI on 1 active trial
RM
Rachel DEBS, MD
Specialist
PI on 2 active trials
DM
David Ward, MD
Specialist
PI on 1 active trial
JP
Jan Ramaekers, PhD
Specialist
PI on 1 active trial
CD
Catherine Dunyach-Remy
Specialist
PI on 1 active trial
MM
Mona S Aldosari, Masteral
Specialist
PI on 1 active trial
JP
Jacques Montplaisir, MD, PhD
Specialist
PI on 1 active trial
PP
Pierre PHILIP, MD, PHD
NEW CANAAN, CT
Specialist
PI on 1 active trial
JM
James Maynard, MD
Specialist
PI on 2 active trials
JP
Jennifer Mundt, PhD
CHICAGO, IL
Specialist
PI on 2 active trials
GA
George Apostol
Specialist
PI on 1 active trial
KM
Kiran Maski
BOSTON, MA
Specialist
PI on 1 active trial
GC
Giovanni Cizza
Specialist
PI on 1 active trial
DM
Dagmar A Schmid, Dr. med
Specialist
PI on 1 active trial
WH
William Houghton
MILWAUKEE, WI
Specialist
PI on 1 active trial
MF
Maria-Livia FANTINI
Specialist
PI on 1 active trial
YL
Yue-Joe Lee
Specialist
PI on 1 active trial
LS
LuAnn Sabounjian
Specialist
PI on 1 active trial
ML
Michel Lecendreux
Specialist
4 Narcolepsy publications
CB
Claudio L A Bassetti
Specialist
3 Narcolepsy publications
UK
Ulf Kallweit
Specialist
3 Narcolepsy publications
PJ
Poul Jennum
Specialist
3 Narcolepsy publications
RK
Ramin Khatami
Specialist
3 Narcolepsy publications
MP
Markku Partinen
Specialist
3 Narcolepsy publications

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Financial Resources

3 resources
Lumryz(sodium oxybate)— Flamel Ireland Limited dba Avadel Ireland
Xywav(calcium, magnesium, potassium, and sodium oxybates)— Jazz Pharmaceuticals Ireland Limited
Sunosi(Solriamfetol)— Axsome Malta, Ltd.

Travel Grants

No travel grants are currently matched to Narcolepsy.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Narcolepsy

Disease timeline:

New recruiting trial: A Trial of TAK-861 for the Treatment of Narcolepsy With Cataplexy

A new clinical trial is recruiting patients for Narcolepsy

New recruiting trial: Bacterial Translocation and Gut Microbiota in Type 1 Narcolepsy Patients Versus a Control Population

A new clinical trial is recruiting patients for Narcolepsy

New recruiting trial: A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions

A new clinical trial is recruiting patients for Narcolepsy

New recruiting trial: Epidemiology of Narcolepsy Type 1 and Type 2 in Spain

A new clinical trial is recruiting patients for Narcolepsy

New recruiting trial: Proteomics and Metabolomics of Body Fluid in Patients With Narcolepsy

A new clinical trial is recruiting patients for Narcolepsy

New recruiting trial: Mentalizating in Adults Suffering from Narcolepsy Type 1.

A new clinical trial is recruiting patients for Narcolepsy

New recruiting trial: Child and Adolescent Registry for Participants With Narcolepsy

A new clinical trial is recruiting patients for Narcolepsy

New recruiting trial: Extended-release Sodium Oxybate in Children

A new clinical trial is recruiting patients for Narcolepsy

New recruiting trial: WAKIX® (Pitolisant) Pregnancy Registry

A new clinical trial is recruiting patients for Narcolepsy

New recruiting trial: A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)

A new clinical trial is recruiting patients for Narcolepsy

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Narcolepsy

Are there clinical trials for Narcolepsy?

Yes — 15 recruiting clinical trials are currently listed for Narcolepsy on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Narcolepsy?

25 specialists and care centers treating Narcolepsy are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for Narcolepsy?

3 patient support programs are currently tracked on UniteRare for Narcolepsy. See the treatments and support programs sections for copay assistance, eligibility, and contact details.