Overview
Multifocal atrial tachycardia (MAT), sometimes called chaotic atrial tachycardia or chaotic atrial rhythm, is a heart rhythm disorder where the upper chambers of the heart (the atria) beat too fast and in an irregular, disorganized way. Normally, the heart's electrical signal starts from one spot and travels in an orderly pattern. In MAT, at least three different areas in the atria are sending out electrical signals at the same time, causing the heart to beat rapidly and unpredictably — usually faster than 100 beats per minute. This condition most often affects people who already have a serious underlying illness, especially lung diseases like chronic obstructive pulmonary disease (COPD), pneumonia, or heart failure. It can also be triggered by low oxygen levels, certain medications, or electrolyte imbalances (like low potassium or magnesium). In newborns and infants, MAT can occur without an obvious cause and often resolves on its own. Common symptoms include a racing or fluttering heartbeat, shortness of breath, dizziness, chest discomfort, and fatigue. Treatment focuses on managing the underlying cause — for example, treating a lung infection or correcting electrolyte levels. Medications to slow the heart rate, such as calcium channel blockers or beta-blockers, may also be used. In most adults, controlling the root cause leads to improvement in the heart rhythm.
Also known as:
Key symptoms:
Fast, irregular heartbeat (palpitations)Shortness of breathDizziness or lightheadednessChest discomfort or tightnessFatigue or unusual tirednessFainting or near-fainting spellsReduced ability to exercise or be activeAnxiety or feeling of uneaseLow blood pressure in some casesSwelling in the legs or ankles (if heart failure is also present)
Clinical phenotype terms (25)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsSeoul National University Hospital — NA
Necmettin Erbakan University — NA
Sligo General Hospital — NA
Chinese University of Hong Kong — NA
Florida International University — NA
The University of Texas Health Science Center, Houston — NA
Universidade do Porto — NA
Shanghai 6th People's Hospital
Cairo University — NA
Badr University — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Multifocal atrial tachycardia.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Multifocal atrial tachycardia at this time.
New trials open frequently. Follow this disease to get notified.
Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Multifocal atrial tachycardia.
Community
No community posts yet. Be the first to share your experience with Multifocal atrial tachycardia.
Start the conversation →Latest news about Multifocal atrial tachycardia
Disease timeline:
New recruiting trial: Validation of Five Seasons Sleep Tracking Mat for the Diagnosis of Obstructive Sleep Apnea
A new clinical trial is recruiting patients for Multifocal atrial tachycardia
New recruiting trial: High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)
A new clinical trial is recruiting patients for Multifocal atrial tachycardia
New recruiting trial: Comparison of the Effects of Aerobic Exercise Training and Mat Pilates Exercise on Blood Pressure, Functional Capacity and Quality of Life in Hypertensive Individuals
A new clinical trial is recruiting patients for Multifocal atrial tachycardia
New recruiting trial: Effects of a Second-generation Mindfulness-based Intervention on Quality of Life, Pain Management, and Psycho-spiritual Wellbeing in Cancer Patients: A Randomised Controlled Trial
A new clinical trial is recruiting patients for Multifocal atrial tachycardia
New recruiting trial: A Trial of Staff Time With Proned Patients in the ICU Using the 'BathMat'
A new clinical trial is recruiting patients for Multifocal atrial tachycardia
New recruiting trial: Mat Pilates on Body Awareness and Physical Activity Levels in Sedentary Emerging Adulthood Women
A new clinical trial is recruiting patients for Multifocal atrial tachycardia
New recruiting trial: Evaluation of Clinical-functional and Radiographic Outcomes in Patients Who Underwent Meniscal Allograft Transplantation (MAT) at 10 Years.
A new clinical trial is recruiting patients for Multifocal atrial tachycardia
New recruiting trial: Pulsed Electro-Magnetic Field Therapy for Treatment of Midportion Achilles Tendinopathy
A new clinical trial is recruiting patients for Multifocal atrial tachycardia
New recruiting trial: Supporting Treatment Access and Recovery Through Linkage and Support
A new clinical trial is recruiting patients for Multifocal atrial tachycardia
New recruiting trial: Evaluating a Culinary Curriculum Program for Residents of Medication Assisted Therapy (MAT) Recovery Houses
A new clinical trial is recruiting patients for Multifocal atrial tachycardia
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is causing my MAT, and how do we treat that underlying cause?,Which medications are you recommending to control my heart rate, and what are the side effects?,How will we know if the treatment is working — what should I watch for at home?,Are there any activities or medications I should avoid while I have this condition?,When should I go to the emergency room versus calling your office?,Will my heart rhythm go back to normal once the underlying cause is treated?,Do I need any follow-up heart monitoring, like a Holter monitor or repeat ECG?
Common questions about Multifocal atrial tachycardia
What is Multifocal atrial tachycardia?
Multifocal atrial tachycardia (MAT), sometimes called chaotic atrial tachycardia or chaotic atrial rhythm, is a heart rhythm disorder where the upper chambers of the heart (the atria) beat too fast and in an irregular, disorganized way. Normally, the heart's electrical signal starts from one spot and travels in an orderly pattern. In MAT, at least three different areas in the atria are sending out electrical signals at the same time, causing the heart to beat rapidly and unpredictably — usually faster than 100 beats per minute. This condition most often affects people who already have a serio
How is Multifocal atrial tachycardia inherited?
Multifocal atrial tachycardia follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Which specialists treat Multifocal atrial tachycardia?
3 specialists and care centers treating Multifocal atrial tachycardia are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.