Multifocal atrial tachycardia

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Multifocal atrial tachycardia (MAT), sometimes called chaotic atrial tachycardia or chaotic atrial rhythm, is a heart rhythm disorder where the upper chambers of the heart (the atria) beat too fast and in an irregular, disorganized way. Normally, the heart's electrical signal starts from one spot and travels in an orderly pattern. In MAT, at least three different areas in the atria are sending out electrical signals at the same time, causing the heart to beat rapidly and unpredictably — usually faster than 100 beats per minute. This condition most often affects people who already have a serious underlying illness, especially lung diseases like chronic obstructive pulmonary disease (COPD), pneumonia, or heart failure. It can also be triggered by low oxygen levels, certain medications, or electrolyte imbalances (like low potassium or magnesium). In newborns and infants, MAT can occur without an obvious cause and often resolves on its own. Common symptoms include a racing or fluttering heartbeat, shortness of breath, dizziness, chest discomfort, and fatigue. Treatment focuses on managing the underlying cause — for example, treating a lung infection or correcting electrolyte levels. Medications to slow the heart rate, such as calcium channel blockers or beta-blockers, may also be used. In most adults, controlling the root cause leads to improvement in the heart rhythm.

Also known as:

Key symptoms:

Fast, irregular heartbeat (palpitations)Shortness of breathDizziness or lightheadednessChest discomfort or tightnessFatigue or unusual tirednessFainting or near-fainting spellsReduced ability to exercise or be activeAnxiety or feeling of uneaseLow blood pressure in some casesSwelling in the legs or ankles (if heart failure is also present)

Clinical phenotype terms (25)— hover any for plain English
Abnormal PR intervalHP:0031593Irregular RR intervalHP:6001086Irregular P-P intervalHP:6001087Atrial flutterHP:0004749Atrial fibrillationHP:0005110Atrioventricular valve regurgitationHP:0034376Fetal tachycardiaHP:6000264Effort-induced polymorphic ventricular tachycardiaHP:0004758Abnormal left ventricular functionHP:0005162Atrioventricular reentrant tachycardiaHP:0011717Left ventricular dilatationHP:4000141
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Dec 2025CRESCENDO: ChildREn's muSiC ENhancement in Cochlear Implant Users

Seoul National University Hospital — NA

TrialNOT YET RECRUITING
Dec 2025Mat Pilates on Body Awareness and Physical Activity Levels in Sedentary Emerging Adulthood Women

Necmettin Erbakan University — NA

TrialRECRUITING
Nov 2025Impact of Cooling Mats on Vasomotor Symptoms in Patients Receiving Endocrine Therapy

Sligo General Hospital — NA

TrialENROLLING BY INVITATION
Oct 2025Pulsed Electro-Magnetic Field Therapy for Treatment of Midportion Achilles Tendinopathy

Chinese University of Hong Kong — NA

TrialRECRUITING
Oct 2025Evaluating a Mat-Based Biometric Vibration System for Sleep and Daily Recovery

Florida International University — NA

TrialRECRUITING
Aug 2025Evaluating a Culinary Curriculum Program for Residents of Medication Assisted Therapy (MAT) Recovery Houses

The University of Texas Health Science Center, Houston — NA

TrialRECRUITING
Aug 2025Effects of 20-week Mat-Pilates & Dual-Task Training on Strength, Balance, Cognition, and Fall Risk in Older Adults

Universidade do Porto — NA

TrialACTIVE NOT RECRUITING
Apr 2025Validation of Five Seasons Sleep Tracking Mat for the Diagnosis of Obstructive Sleep Apnea

Shanghai 6th People's Hospital

TrialRECRUITING
Feb 2025Pilates Mat Versus Segmental Control Exercises in Patients with Chronic Non-Specific Low Back Pain

Cairo University — NA

TrialNOT YET RECRUITING
Jan 2025Pilates Mat Exercises Training on Functional Performance in Middle Age Obese Women

Badr University — NA

TrialNOT YET RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Multifocal atrial tachycardia.

View clinical trials →

No actively recruiting trials found for Multifocal atrial tachycardia at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Multifocal atrial tachycardia community →

Specialists

3 foundView all specialists →
HM
Hafiza Muriam Ghani, MSCPPT
Specialist
PI on 3 active trials
MP
Mairead Kiely, PhD
Cork, Co. Cork
Specialist

Rare Disease Specialist

PI on 3 active trials

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Multifocal atrial tachycardia.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Multifocal atrial tachycardia

Disease timeline:

New recruiting trial: Validation of Five Seasons Sleep Tracking Mat for the Diagnosis of Obstructive Sleep Apnea

A new clinical trial is recruiting patients for Multifocal atrial tachycardia

New recruiting trial: High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)

A new clinical trial is recruiting patients for Multifocal atrial tachycardia

New recruiting trial: Comparison of the Effects of Aerobic Exercise Training and Mat Pilates Exercise on Blood Pressure, Functional Capacity and Quality of Life in Hypertensive Individuals

A new clinical trial is recruiting patients for Multifocal atrial tachycardia

New recruiting trial: Effects of a Second-generation Mindfulness-based Intervention on Quality of Life, Pain Management, and Psycho-spiritual Wellbeing in Cancer Patients: A Randomised Controlled Trial

A new clinical trial is recruiting patients for Multifocal atrial tachycardia

New recruiting trial: A Trial of Staff Time With Proned Patients in the ICU Using the 'BathMat'

A new clinical trial is recruiting patients for Multifocal atrial tachycardia

New recruiting trial: Mat Pilates on Body Awareness and Physical Activity Levels in Sedentary Emerging Adulthood Women

A new clinical trial is recruiting patients for Multifocal atrial tachycardia

New recruiting trial: Evaluation of Clinical-functional and Radiographic Outcomes in Patients Who Underwent Meniscal Allograft Transplantation (MAT) at 10 Years.

A new clinical trial is recruiting patients for Multifocal atrial tachycardia

New recruiting trial: Pulsed Electro-Magnetic Field Therapy for Treatment of Midportion Achilles Tendinopathy

A new clinical trial is recruiting patients for Multifocal atrial tachycardia

New recruiting trial: Supporting Treatment Access and Recovery Through Linkage and Support

A new clinical trial is recruiting patients for Multifocal atrial tachycardia

New recruiting trial: Evaluating a Culinary Curriculum Program for Residents of Medication Assisted Therapy (MAT) Recovery Houses

A new clinical trial is recruiting patients for Multifocal atrial tachycardia

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What is causing my MAT, and how do we treat that underlying cause?,Which medications are you recommending to control my heart rate, and what are the side effects?,How will we know if the treatment is working — what should I watch for at home?,Are there any activities or medications I should avoid while I have this condition?,When should I go to the emergency room versus calling your office?,Will my heart rhythm go back to normal once the underlying cause is treated?,Do I need any follow-up heart monitoring, like a Holter monitor or repeat ECG?

Common questions about Multifocal atrial tachycardia

What is Multifocal atrial tachycardia?

Multifocal atrial tachycardia (MAT), sometimes called chaotic atrial tachycardia or chaotic atrial rhythm, is a heart rhythm disorder where the upper chambers of the heart (the atria) beat too fast and in an irregular, disorganized way. Normally, the heart's electrical signal starts from one spot and travels in an orderly pattern. In MAT, at least three different areas in the atria are sending out electrical signals at the same time, causing the heart to beat rapidly and unpredictably — usually faster than 100 beats per minute. This condition most often affects people who already have a serio

How is Multifocal atrial tachycardia inherited?

Multifocal atrial tachycardia follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

Which specialists treat Multifocal atrial tachycardia?

3 specialists and care centers treating Multifocal atrial tachycardia are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.