Manganese poisoning

Manganese poisoning, also called manganism or manganese toxicity, is a condition caused by excessive exposure to the metal manganese. It is not a genetic disease but rather an environmental or occupational illness. Manganese is a naturally occurring element that the body needs in tiny amounts, but when too much builds up in the body — especially in the brain — it can cause serious damage to the nervous system. The condition most commonly affects workers in industries such as mining, welding, steel manufacturing, and battery production, where manganese dust or fumes are inhaled over long periods. It can also occur from contaminated drinking water, certain medications, or in people with liver disease who cannot properly clear manganese from the body. In rare cases, it has been linked to illicit drug use involving manganese-containing compounds. Manganese poisoning primarily damages a part of the brain called the basal ganglia, which controls movement. Early symptoms often include mood changes, irritability, and difficulty sleeping. As the condition progresses, patients may develop tremors, slow movement, stiff muscles, difficulty walking, and problems with balance — symptoms that closely resemble Parkinson's disease. Some people also experience psychiatric symptoms such as hallucinations, aggression, or emotional instability. Treatment focuses on removing the source of manganese exposure and may include chelation therapy to help the body eliminate excess manganese. Unfortunately, some neurological damage may be permanent even after exposure stops.

Bring these to your next appointment

• Q1.What is my current manganese level, and how does it compare to normal?,Has the MRI shown any signs of manganese accumulation in my brain?,Would chelation therapy be appropriate in my case, and what are the risks and benefits?,Are there medications that could help manage my movement symptoms or mood changes?,What physical therapy or rehabilitation programs would you recommend?,Is the damage I already have likely to be permanent, or could some symptoms improve over time?,How can I make sure my family members or coworkers are not also being exposed?

Common questions about Manganese poisoning

Related conditions

Other rare diseases commonly researched alongside Manganese poisoning.

• Lead poisoning→
• Mercury poisoning→