What is Inherited ichthyosis syndromic form?
Syndromic inherited ichthyosis is a group of rare genetic skin conditions where the word 'ichthyosis' refers to dry, scaly skin that builds up because the skin cannot shed properly. Unlike simple ichthyosis that only affects the skin, the syndromic forms also involve other organs and body systems — which is what makes them 'syndromic.' This group includes several distinct conditions such as Netherton syndrome, Sjögren-Larsson syndrome, CHILD syndrome, KID syndrome (keratitis-ichthyosis-deafness), Refsum disease, and others. Each has its own combination of features beyond the skin. Because these are genetic conditions, they are present from birth or early life, though some features may become more obvious over time. The skin problems can range from redness and peeling to thick, armor-like scales covering large parts of the body. Depending on the specific syndrome, a person may also experience neurological problems, vision or hearing loss, intellectual disability, liver disease, or problems with the immune system. Treatment focuses on managing symptoms rather than curing the disease. Skin care is a major part of daily life and includes regular moisturizing, gentle bathing routines, and sometimes prescription creams or retinoids. Other symptoms are managed by the relevant specialists. Research into gene therapy and targeted treatments is ongoing, giving hope for better options in the future.
Key symptoms:
Dry, scaly, or thickened skin covering large areas of the bodyRedness of the skin (erythroderma), sometimes present from birthSkin that peels or sheds in large flakesItching that can be severe and constantHair that is fragile, sparse, or has an unusual structure under a microscopeVision problems, including sensitivity to light or corneal damageHearing loss, which may be present from birth or develop over timeNeurological problems such as difficulty walking, muscle stiffness, or intellectual disabilityLiver disease or abnormal liver functionFrequent skin infections due to a damaged skin barrierFailure to thrive or poor growth in infancyJoint problems or limited movementSensitivity to heat because sweating may be reducedSeizures in some syndromic formsImmune system problems leading to repeated infections
- Inheritance
- Variable
- Can be inherited in different ways depending on the underlying gene
- Age of Onset
- Variable
- Can begin at different ages, from infancy through adulthood
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for Inherited ichthyosis syndromic form.
View clinical trials →Clinical Trials
View all trials with filters →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
No actively recruiting trials found for Inherited ichthyosis syndromic form at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for Inherited ichthyosis syndromic form.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to Inherited ichthyosis syndromic form.
Community
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Start the conversation →Latest news about Inherited ichthyosis syndromic form
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for Inherited ichthyosis syndromic form.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Which specific syndrome do I (or my child) have, and what does that mean for the organs beyond the skin?,What genetic test should be done, and will results help guide treatment decisions?,What is the best daily skin care routine, and are there products you specifically recommend?,Are retinoids or other prescription treatments appropriate for my situation, and what are the risks?,What warning signs of complications should prompt me to seek emergency care?,Are there clinical trials or research studies I should know about?,What support services — such as psychological counseling, physiotherapy, or social work — are available to us?
Common questions about Inherited ichthyosis syndromic form
What is Inherited ichthyosis syndromic form?
Syndromic inherited ichthyosis is a group of rare genetic skin conditions where the word 'ichthyosis' refers to dry, scaly skin that builds up because the skin cannot shed properly. Unlike simple ichthyosis that only affects the skin, the syndromic forms also involve other organs and body systems — which is what makes them 'syndromic.' This group includes several distinct conditions such as Netherton syndrome, Sjögren-Larsson syndrome, CHILD syndrome, KID syndrome (keratitis-ichthyosis-deafness), Refsum disease, and others. Each has its own combination of features beyond the skin. Because the
Frequently asked questions about Inherited ichthyosis syndromic form
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is Inherited ichthyosis syndromic form?
Inherited ichthyosis syndromic form is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:281085). It is typically inherited as variable. Age of onset is generally variable. For verified primary sources, see the UniteRare Inherited ichthyosis syndromic form page.
How is Inherited ichthyosis syndromic form inherited?
Inherited ichthyosis syndromic form follows variable inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for Inherited ichthyosis syndromic form?
Approved treatments for Inherited ichthyosis syndromic form are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials for Inherited ichthyosis syndromic form?
Active clinical trials for Inherited ichthyosis syndromic form are tracked daily from ClinicalTrials.gov. Trial availability changes frequently; check the UniteRare trial listings for the current count and recruitment status. Sponsors of rare-disease research often welcome inquiries even when a trial is not actively recruiting at a given moment.
How do I find a specialist for Inherited ichthyosis syndromic form?
Verified Inherited ichthyosis syndromic form specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full Inherited ichthyosis syndromic form page for complete clinical details, sources, and verified-specialist listings.
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