Overview
Inhalational anthrax, also called woolsorters' disease or pulmonary anthrax, is a serious and life-threatening infection caused by breathing in spores of the bacterium Bacillus anthracis. This is not a genetic disease — it is an infectious disease that occurs when a person inhales enough spores to trigger an infection in the lungs and surrounding tissues. Once inside the body, the spores travel to lymph nodes in the chest, where they activate and begin producing powerful toxins that damage the body's organs and immune system. The disease typically starts with mild, flu-like symptoms such as fever, fatigue, and mild chest discomfort. This early stage can be deceptive because it may seem like a common illness. However, within one to three days, the condition can rapidly worsen into a severe, life-threatening emergency with difficulty breathing, shock, and widespread infection in the blood (septicemia). The chest cavity may fill with fluid, making breathing extremely difficult. Inhalational anthrax is considered the most dangerous form of anthrax infection. Treatment relies on powerful antibiotics such as ciprofloxacin, doxycycline, and amoxicillin, often combined with antitoxin medications. Early treatment dramatically improves survival chances. Without prompt treatment, the disease is almost always fatal. Because of its potential use as a bioterrorism agent, inhalational anthrax is closely monitored by public health authorities worldwide.
Also known as:
Key symptoms:
Fever and chillsExtreme tiredness and weaknessMild chest pain or discomfortShortness of breath that gets worse quicklySweating, including night sweatsNausea and vomitingHeadacheConfusion or altered mental stateRapid heart rateLow blood pressure (shock)Swelling in the neck or chest areaBluish skin color due to lack of oxygenFluid buildup around the lungs
Clinical phenotype terms (12)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
3 eventsEmergent BioSolutions
Emergent BioSolutions
ABthraxTM: FDA approved
Treatment of inhalation anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs,
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
2 availableAnthim
indicated in adult and pediatric patients for the treatment of inhalational anthrax due to B. anthracis in combination with appropriate antibacterial drugs
ABthraxTM
Treatment of inhalation anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs,
Clinical Trials
View all trials with filters →No actively recruiting trials found for Inhalational anthrax at this time.
New trials open frequently. Follow this disease to get notified.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Inhalational anthrax.
Community
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Start the conversation →Latest news about Inhalational anthrax
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How certain are you that this is inhalational anthrax, and what tests confirmed the diagnosis?,Which antibiotics will I be given, and how long will I need to take them?,Will I receive antitoxin treatment, and what are the benefits and risks?,What are the signs that my condition is improving or getting worse?,Is there any risk to my family members or people I have been in contact with?,What long-term effects on my lungs or other organs should I watch for after recovery?,Are there any public health steps I or my family need to take, such as preventive antibiotics or vaccination?
Common questions about Inhalational anthrax
What is Inhalational anthrax?
Inhalational anthrax, also called woolsorters' disease or pulmonary anthrax, is a serious and life-threatening infection caused by breathing in spores of the bacterium Bacillus anthracis. This is not a genetic disease — it is an infectious disease that occurs when a person inhales enough spores to trigger an infection in the lungs and surrounding tissues. Once inside the body, the spores travel to lymph nodes in the chest, where they activate and begin producing powerful toxins that damage the body's organs and immune system. The disease typically starts with mild, flu-like symptoms such as f
How is Inhalational anthrax inherited?
Inhalational anthrax follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Which specialists treat Inhalational anthrax?
25 specialists and care centers treating Inhalational anthrax are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.
What treatment and support options exist for Inhalational anthrax?
2 patient support programs are currently tracked on UniteRare for Inhalational anthrax. See the treatments and support programs sections for copay assistance, eligibility, and contact details.