Overview
Infantile apnea (also called apnea of infancy) is a condition where a baby stops breathing for a short period of time — usually 20 seconds or longer — or has a shorter pause in breathing that causes a drop in heart rate or oxygen levels. This is different from the normal brief pauses in breathing that all babies have. The condition most often affects babies in the first few months of life and can be frightening for parents and caregivers. The breathing pauses happen because the part of the brain that controls breathing is still maturing. In some babies, the airway may also briefly collapse or become blocked. These episodes can cause the baby to turn pale, bluish, or limp. Some episodes happen during sleep, while others can occur while the baby is awake. Most babies with infantile apnea are monitored closely, often with a home breathing monitor. Some may need caffeine therapy or other treatments to stimulate breathing. The good news is that most babies outgrow this condition as their nervous system matures, usually by the time they reach their expected due date or a few months after. However, some cases are linked to underlying medical conditions that need their own treatment.
Also known as:
Key symptoms:
Pauses in breathing lasting 20 seconds or moreSkin turning blue or purple (cyanosis)Skin turning pale or whiteLimpness or loss of muscle tone during an episodeSlow heart rate (bradycardia) during a breathing pauseLow oxygen levels in the bloodChoking or gagging soundsDifficulty feedingUnusual sleepiness or hard to wake upIrregular breathing patterns
Multifactorial
Caused by a mix of several genes and environmental factors
Neonatal
Begins at or shortly after birth (first 4 weeks)
FDA & Trial Timeline
1 eventGuilherme Sant'Anna, MD — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
1 availableXGEVA
Treatment of hypercalcemia of malignancy refractory to bisphosphonate therapy
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Financial Resources
1 resourcesTravel Grants
No travel grants are currently matched to Infantile apnea.
Community
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Start the conversation →Latest news about Infantile apnea
Disease timeline:
New recruiting trial: Advanced Wireless Sensors for Neonatal Care in the Delivery Room
A new clinical trial is recruiting patients for Infantile apnea
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is causing my baby's apnea — is it related to prematurity or is there another underlying condition?,Does my baby need a home apnea monitor, and how long will they need it?,Is caffeine or another medication recommended for my baby?,What should I do if my baby has an apnea episode at home?,When do you expect my baby to outgrow this condition?,Are there any signs I should watch for that would mean the apnea is getting worse?,Will this condition affect my baby's development or long-term health?
Common questions about Infantile apnea
What is Infantile apnea?
Infantile apnea (also called apnea of infancy) is a condition where a baby stops breathing for a short period of time — usually 20 seconds or longer — or has a shorter pause in breathing that causes a drop in heart rate or oxygen levels. This is different from the normal brief pauses in breathing that all babies have. The condition most often affects babies in the first few months of life and can be frightening for parents and caregivers. The breathing pauses happen because the part of the brain that controls breathing is still maturing. In some babies, the airway may also briefly collapse or
How is Infantile apnea inherited?
Infantile apnea follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Infantile apnea typically begin?
Typical onset of Infantile apnea is neonatal. Age of onset can vary across affected individuals.
Are there clinical trials for Infantile apnea?
Yes — 1 recruiting clinical trial is currently listed for Infantile apnea on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Infantile apnea?
6 specialists and care centers treating Infantile apnea are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.