Infantile apnea

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1FDA treatments1Active trials6Specialists8Treatment centers1Financial resources

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Infantile apnea (also called apnea of infancy) is a condition where a baby stops breathing for a short period of time — usually 20 seconds or longer — or has a shorter pause in breathing that causes a drop in heart rate or oxygen levels. This is different from the normal brief pauses in breathing that all babies have. The condition most often affects babies in the first few months of life and can be frightening for parents and caregivers. The breathing pauses happen because the part of the brain that controls breathing is still maturing. In some babies, the airway may also briefly collapse or become blocked. These episodes can cause the baby to turn pale, bluish, or limp. Some episodes happen during sleep, while others can occur while the baby is awake. Most babies with infantile apnea are monitored closely, often with a home breathing monitor. Some may need caffeine therapy or other treatments to stimulate breathing. The good news is that most babies outgrow this condition as their nervous system matures, usually by the time they reach their expected due date or a few months after. However, some cases are linked to underlying medical conditions that need their own treatment.

Also known as:

Key symptoms:

Pauses in breathing lasting 20 seconds or moreSkin turning blue or purple (cyanosis)Skin turning pale or whiteLimpness or loss of muscle tone during an episodeSlow heart rate (bradycardia) during a breathing pauseLow oxygen levels in the bloodChoking or gagging soundsDifficulty feedingUnusual sleepiness or hard to wake upIrregular breathing patterns

Inheritance

Multifactorial

Caused by a mix of several genes and environmental factors

Age of Onset

Neonatal

Begins at or shortly after birth (first 4 weeks)

Orphanet ↗NORD ↗

FDA & Trial Timeline

1 event
Apr 2025Advanced Wireless Sensors for Neonatal Care in the Delivery Room

Guilherme Sant'Anna, MD — NA

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

1 available

XGEVA

denosumab· Amgen, Inc.

Treatment of hypercalcemia of malignancy refractory to bisphosphonate therapy

Clinical Trials

1 recruitingView all trials with filters →
N/A1 trial
Advanced Wireless Sensors for Neonatal Care in the Delivery Room
N/A
Actively Recruiting
PI: Guilherme Sant'Anna, MD, PhD (The Research institute of the McGill University He) · Sites: Buenos Aires; Umuarama, Minas Gerais +5 more

Specialists

6 foundView all specialists →
GP
Guilherme Sant'Anna, MD, PhD
Specialist
PI on 1 active trial
FP
Francesco Cresi, MD, PhD
Specialist
PI on 2 active trials
TM
Thomas Riva, M.D.
Specialist
PI on 1 active trial
AM
Alexander Fuchs, M.D.
Specialist
PI on 1 active trial
ES
Elisabeth Salisbury
Specialist
PI on 1 active trial
AG
Adeline Gerst
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Financial Resources

1 resources
XGEVA(denosumab)Amgen, Inc.

Travel Grants

No travel grants are currently matched to Infantile apnea.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Infantile apnea

Disease timeline:

New recruiting trial: Advanced Wireless Sensors for Neonatal Care in the Delivery Room

A new clinical trial is recruiting patients for Infantile apnea

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What is causing my baby's apnea — is it related to prematurity or is there another underlying condition?,Does my baby need a home apnea monitor, and how long will they need it?,Is caffeine or another medication recommended for my baby?,What should I do if my baby has an apnea episode at home?,When do you expect my baby to outgrow this condition?,Are there any signs I should watch for that would mean the apnea is getting worse?,Will this condition affect my baby's development or long-term health?

Common questions about Infantile apnea

What is Infantile apnea?

Infantile apnea (also called apnea of infancy) is a condition where a baby stops breathing for a short period of time — usually 20 seconds or longer — or has a shorter pause in breathing that causes a drop in heart rate or oxygen levels. This is different from the normal brief pauses in breathing that all babies have. The condition most often affects babies in the first few months of life and can be frightening for parents and caregivers. The breathing pauses happen because the part of the brain that controls breathing is still maturing. In some babies, the airway may also briefly collapse or

How is Infantile apnea inherited?

Infantile apnea follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Infantile apnea typically begin?

Typical onset of Infantile apnea is neonatal. Age of onset can vary across affected individuals.

Are there clinical trials for Infantile apnea?

Yes — 1 recruiting clinical trial is currently listed for Infantile apnea on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Infantile apnea?

6 specialists and care centers treating Infantile apnea are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.