Apnea of prematurity

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ORPHA:99981P28.4
Who is this for?
Show terms as
1FDA treatments8Active trials107Specialists8Treatment centers

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Clinical phenotype terms— hover any for plain English:

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Jun 2026The Effect of Caffeine Therapy in Cardiovascular Stability in Preterm Neonates at Assiut University Children Hospital NICU

Assiut University

TrialNOT YET RECRUITING
Apr 2026Caffeine Citrate in Preterm Infants at Risk of Apnea in Zambia

University of Alabama at Birmingham — PHASE4

TrialNOT YET RECRUITING
Jan 2026The Role of Electroencephalography in Caffeine Discontinuation Timing in Premature Infants

Uludag University

TrialNOT YET RECRUITING
Dec 2025Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates

Michelle Baczynski — NA

TrialRECRUITING
Oct 2025Caffeine Citrate to Improve Neonatal Outcomes.

University of Melbourne — NA

TrialNOT YET RECRUITING
Feb 2025"Prapela® SVS Incubator Pad for Apnea of Prematurity

Tufts Medical Center — NA

TrialRECRUITING
Oct 2024Post-Extubation Assessment of Clinical Stability in ELBW Infants

McGill University Health Centre/Research Institute of the McGill University Health Centre

TrialRECRUITING
Sep 2024Efficacy of PIMUN by Reducing Intermittent Hypoxia Events

Pontificia Universidad Catolica de Chile — NA

TrialRECRUITING
Jun 2024Apnea of Prematurity Results in Respiratory Distress and Cyanosis. Caffeine Citrate Can Treat It.

Nishtar Medical University — PHASE1

TrialACTIVE NOT RECRUITING
Feb 2024Caffeine Use in the Management of Preterm Infants

University of California, Irvine — PHASE2

TrialACTIVE NOT RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

1 available

Cafcit

Caffeine· O.P.R. Development, L.P.Orphan Drug

Short term treatment of apnea of prematurity in infants between 28 and less than 33 weeks gestational age.

Clinical Trials

8 recruitingView all trials with filters →
Phase 31 trial
Doxapram Therapy in Preterm Infants (DOXA Trial)
Phase 3
Actively Recruiting
PI: Anne Smits, MD, PhD (Universitair Ziekenhuis Leuven) · Sites: Brussels, Avenaue Hippocrate 10; Brussels, Brussels Capital +22 more
Phase 41 trial
The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate
Phase 4
Actively Recruiting
PI: Ákos Gasparics, MD.PhD (Semmelweis University, Department of Obstetrics an) · Sites: Budapest; Budapest
Phase 21 trial
Caffeine Use in the Management of Preterm Infants
Phase 2
Active
PI: Cherry Uy, MD (UC Irvine) · Sites: Orange, California
Phase 11 trial
Apnea of Prematurity Results in Respiratory Distress and Cyanosis. Caffeine Citrate Can Treat It.
Phase 1
Active
PI: Fatima Zahra, FCPS (Nishtar Medical University) · Sites: Multan, Punjab Province
N/A3 trials
Efficacy of PIMUN by Reducing Intermittent Hypoxia Events
N/A
Actively Recruiting
· Sites: Santiago, Santiago Metropolitan; Santiago, Santiago Metropolitan
The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants
N/A
Actively Recruiting
PI: Cynthia Bearer, MD (University Hospitals Cleveland Medical Center) · Sites: Cleveland, Ohio
"Prapela® SVS Incubator Pad for Apnea of Prematurity
N/A
Actively Recruiting
· Sites: Birmingham, Alabama; Boston, Massachusetts
Other1 trial
Detection of CardioRespiratory Events Using Acoustic Monitoring in Preterm Infants on CPAP
Active
PI: Wissam M Shalish, MD PhD (McGill University Health Centre/Research Institute) · Sites: Montreal, Quebec

Specialists

Showing 25 of 107View all specialists →
DM
Diane Moddemann, MD
Specialist
PI on 1 active trial
WM
Win Tin, MD
Specialist
PI on 1 active trial
AM
Alfonso Solimano, MD
Specialist
PI on 1 active trial
KP
Karel Allegaert, MD, PhD
Specialist
PI on 1 active trial
AM
Arne Ohlsson, MD
Specialist
PI on 1 active trial
AP
Anne Smits, MD, PhD
GULFPORT, MS
Specialist
PI on 1 active trial
DM
Deborah Dewey, MD
LANSING, MI
Specialist
PI on 1 active trial
KM
Keith J Barrington, MD
Specialist
PI on 1 active trial
EM
Elizabeth Asztalos, MD
Specialist
PI on 1 active trial
PM
Peter Davis, MD
Specialist
PI on 1 active trial
PP
Peter Anderson, PhD
Specialist
PI on 1 active trial
LM
Lex Doyle, MD
Specialist
PI on 1 active trial
RM
Ruth Grunau, MD
Specialist
PI on 1 active trial
SM
sameh m abbas, master
Specialist
PI on 1 active trial
NM
nehad a nasef, MD
Specialist
PI on 1 active trial
JM
Janine Thomann, MD
Specialist
PI on 1 active trial
MM
Michael Kamitsuka, MD
SEATTLE, WA
Specialist
PI on 1 active trial
LM
Luigi Corvaglia, MD
Specialist
PI on 1 active trial
WP
Wissam M Shalish, MD PhD
Specialist
PI on 1 active trial
CM
Cynthia Bearer, MD
BALTIMORE, MD
Specialist
PI on 1 active trial
AM
Andrea Trembath, MD
CLEVELAND, OH
Specialist
PI on 1 active trial
RM
Rachel G Greenberg, MD
Specialist
PI on 1 active trial
PP
Patrick Pladys, MD, PhD
Specialist
PI on 1 active trial
EM
Edward F. Bell, M.D.
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Apnea of prematurity.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Apnea of prematurity

Disease timeline:

New recruiting trial: The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate

A new clinical trial is recruiting patients for Apnea of prematurity

New recruiting trial: Doxapram Therapy in Preterm Infants (DOXA Trial)

A new clinical trial is recruiting patients for Apnea of prematurity

New recruiting trial: "Prapela® SVS Incubator Pad for Apnea of Prematurity

A new clinical trial is recruiting patients for Apnea of prematurity

New recruiting trial: Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates

A new clinical trial is recruiting patients for Apnea of prematurity

New recruiting trial: Efficacy of PIMUN by Reducing Intermittent Hypoxia Events

A new clinical trial is recruiting patients for Apnea of prematurity

New recruiting trial: Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

A new clinical trial is recruiting patients for Apnea of prematurity

New recruiting trial: The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants

A new clinical trial is recruiting patients for Apnea of prematurity

New recruiting trial: Post-Extubation Assessment of Clinical Stability in ELBW Infants

A new clinical trial is recruiting patients for Apnea of prematurity

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Apnea of prematurity

Are there clinical trials for Apnea of prematurity?

Yes — 8 recruiting clinical trials are currently listed for Apnea of prematurity on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Apnea of prematurity?

25 specialists and care centers treating Apnea of prematurity are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.