Overview
Feingold syndrome type 2 (also called FS2) is a very rare genetic condition that affects how certain parts of the body develop before birth. It is caused by tiny deletions (missing pieces) on chromosome 13 in a region that contains small RNA molecules called microRNAs, specifically the MIR17HG gene cluster. Unlike Feingold syndrome type 1, which is caused by changes in the MYCN gene, type 2 shares some features but has its own distinct genetic cause. The main features of Feingold syndrome type 2 include short fingers and toes (brachydactyly), especially shortening of the second and fifth fingers, and sometimes webbing or fusion of the toes (syndactyly). Some individuals may also have learning difficulties or mild intellectual disability. Small head size (microcephaly) and short stature can also be present. Importantly, unlike type 1, gastrointestinal atresias (blockages in the digestive tract) are generally not a prominent feature of type 2. There is currently no cure for Feingold syndrome type 2. Treatment focuses on managing individual symptoms. Orthopedic care may be needed for hand or foot differences, and educational support can help children who have learning challenges. Regular follow-up with a clinical geneticist and other specialists is recommended to monitor growth and development over time.
Also known as:
Key symptoms:
Short fingers and toes (brachydactyly)Shortened second and fifth fingersWebbing or fusion of toesSmall head size (microcephaly)Short statureLearning difficulties or mild intellectual disabilityBony abnormalities of the handsToe abnormalitiesDelayed developmental milestones
Clinical phenotype terms (15)— hover any for plain English
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Neonatal
Begins at or shortly after birth (first 4 weeks)
FDA & Trial Timeline
1 eventBirch BioMed Inc — PHASE2, PHASE3
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Feingold syndrome type 2.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Feingold syndrome type 2 at this time.
New trials open frequently. Follow this disease to get notified.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Feingold syndrome type 2.
Community
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Start the conversation →Latest news about Feingold syndrome type 2
Disease timeline:
New recruiting trial: Post-Operative Use of FS2 to Mitigate Scarring in Burn Patients
A new clinical trial is recruiting patients for Feingold syndrome type 2
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What specific genetic change was found, and what does it mean for my child?,Should other family members be tested for this deletion?,What developmental milestones should I watch for, and when should I be concerned?,Does my child need any hand or foot specialist evaluations?,What educational supports or therapies would you recommend?,How often should we schedule follow-up visits?,Are there any research studies or clinical trials we could participate in?
Common questions about Feingold syndrome type 2
What is Feingold syndrome type 2?
Feingold syndrome type 2 (also called FS2) is a very rare genetic condition that affects how certain parts of the body develop before birth. It is caused by tiny deletions (missing pieces) on chromosome 13 in a region that contains small RNA molecules called microRNAs, specifically the MIR17HG gene cluster. Unlike Feingold syndrome type 1, which is caused by changes in the MYCN gene, type 2 shares some features but has its own distinct genetic cause. The main features of Feingold syndrome type 2 include short fingers and toes (brachydactyly), especially shortening of the second and fifth fing
How is Feingold syndrome type 2 inherited?
Feingold syndrome type 2 follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Feingold syndrome type 2 typically begin?
Typical onset of Feingold syndrome type 2 is neonatal. Age of onset can vary across affected individuals.
Which specialists treat Feingold syndrome type 2?
10 specialists and care centers treating Feingold syndrome type 2 are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.