Familial thoracic aortic aneurysm and aortic dissection

Last reviewed March 21, 2026

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ORPHA:91387OMIM:619656I71.2

Who is this for?

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1Active trials 12Specialists 8Treatment centers

Where are you in your journey?

ℹ

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.

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Overview

Also known as:

Familial TAAD FTAAD Familial non-syndromic thoracic aortic aneurysm and aortic dissection Non-syndromic heritable thoracic aortic disease Hereditary thoracic aortic aneurysm and aortic dissection Hereditary TAAD

Clinical phenotype terms— hover any for plain English:

Carotid artery dilatationHP:0012163Dural ectasiaHP:0100775Abnormality of connective tissueHP:0003549Mucoid extracellular matrix accumulationHP:0200146Abnormality iris morphologyHP:0000525Coronary artery atherosclerosisHP:0001677Ascending aortic dissectionHP:0004933Abnormal left ventricular functionHP:0005162Descending aortic dissectionHP:0012499Paroxysmal dyspneaHP:0012763

Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

1 event

Jun 2024Application of Linkage Analysis in the Identification of Novel Hereditary Factors in Familial Aneurysms

IRCCS Policlinico S. Donato

TrialACTIVE NOT RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Familial thoracic aortic aneurysm and aortic dissection.

1 clinical trialare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

1 recruitingView all trials with filters →

Other1 trial

Application of Linkage Analysis in the Identification of Novel Hereditary Factors in Familial Aneurysms

Active

· Sites: San Donato Milanese, Milan · Age: 18–99 yrs

Specialists

12 foundView all specialists →

BM

Benjamin Landis, MD

Atlanta, Georgia

Specialist

Rare Disease Specialist

Arterial tortuosity syndrome Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome due to TPP2 deficiency Autosomal anomaly syndrome+11 more

PI on 1 active trial

Active trials Directions Travel grants

FM

Federico M. Asch, MD,FACC,FASE

WASHINGTON, DC

Specialist

Familial aortic dissection Familial bicuspid aortic valve Galactosialidosis+3 more

PI on 1 active trial

Active trials Directions Travel grants

BM

Barbara Kroner, PhD, MPH

Specialist

Familial aortic dissection Familial bicuspid aortic valve Galactosialidosis+3 more

PI on 1 active trial

Active trials Directions Travel grants

WM

William Ravekes, M.D.

BALTIMORE, MD

Specialist

Familial aortic dissection Familial bicuspid aortic valve Galactosialidosis+3 more

PI on 1 active trial

Active trials Directions Travel grants

RP

Reed E. Pyeritz, M.D., Ph.D.

PHILADELPHIA, PA

Specialist

Familial aortic dissection Familial bicuspid aortic valve Galactosialidosis+3 more

PI on 1 active trial

Active trials Directions Travel grants

JM

Jennifer Habashi, MD

BALTIMORE, MD

Specialist

Familial aortic dissection Familial bicuspid aortic valve Galactosialidosis+3 more

PI on 1 active trial

Active trials Directions Travel grants

DP

Dianna M. Milewicz, M.D. Ph.D.

HOUSTON, TX

Specialist

Familial aortic dissection Familial bicuspid aortic valve Galactosialidosis+3 more

PI on 1 active trial

Active trials Directions Travel grants

RM

Ralph Shohet, MD

HONOLULU, HI

Specialist

Familial aortic dissection Familial bicuspid aortic valve Galactosialidosis+3 more

PI on 1 active trial

Active trials Directions Travel grants

CP

Cheryl L. Maslen, Ph.D.

Specialist

Familial aortic dissection Familial bicuspid aortic valve Galactosialidosis+3 more

PI on 1 active trial

Active trials Directions Travel grants

RM

Richard Devereux, MD

NEW YORK, NY

Specialist

Familial aortic dissection Familial bicuspid aortic valve Galactosialidosis+3 more

PI on 1 active trial

Active trials Directions Travel grants

SM

Scott A. LeMaire, M.D.

HOUSTON, TX

Specialist

Familial aortic dissection Familial bicuspid aortic valve Galactosialidosis+3 more

PI on 1 active trial

Active trials Directions Travel grants

CM

Catherine Boileau, MD

Specialist

Familial aortic dissection

PI on 1 active trial

Active trials Directions Travel grants

Treatment Centers

8 centers

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Familial thoracic aortic aneurysm and aortic dissection.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Familial thoracic aortic aneurysm and aortic dissection

1 articles

Drug approvalRSSApr 24, 2026

FDA Approves First-Ever Gene Therapy for Treatment of Genetic Hearing Loss Under National Priority Voucher Program

The FDA has approved Otarmeni, a new gene therapy treatment for genetic hearing loss. This is the first-of-its-kind treatment that uses a special virus to deliv…

See all news about Familial thoracic aortic aneurysm and aortic dissection →

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Familial thoracic aortic aneurysm and aortic dissection

Are there clinical trials for Familial thoracic aortic aneurysm and aortic dissection?

Yes — 1 recruiting clinical trial is currently listed for Familial thoracic aortic aneurysm and aortic dissection on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Familial thoracic aortic aneurysm and aortic dissection?

12 specialists and care centers treating Familial thoracic aortic aneurysm and aortic dissection are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.