Overview
Complications after organ transplantation refer to a range of medical problems that can happen after a person receives a transplanted organ, such as a kidney, liver, heart, lung, or other organ. These complications are not caused by a single gene or inherited condition, but rather arise from the complex interaction between the transplanted organ and the recipient's body. The most common issue is organ rejection, where the body's immune system attacks the new organ because it recognizes it as foreign. To prevent this, patients must take immunosuppressive medications, which lower the immune system's activity. However, these medications can lead to their own set of problems, including increased risk of infections, certain cancers, high blood pressure, diabetes, and kidney damage. Other complications can include problems with blood vessels connected to the transplanted organ, bile duct or airway issues depending on the organ type, and a condition called graft-versus-host disease where immune cells from the donor organ attack the recipient's body. Some patients may also experience a return of the original disease in the new organ. The treatment landscape focuses on carefully balancing immunosuppressive drugs to prevent rejection while minimizing side effects, treating infections promptly, monitoring organ function through regular blood tests and biopsies, and managing any other health problems that arise. With modern medicine, many transplant recipients live long and productive lives, but lifelong medical follow-up is essential.
Key symptoms:
Fever or chillsSwelling or pain near the transplant siteDecreased urine output (for kidney transplants)Fatigue and weaknessUnexplained weight gain from fluid retentionShortness of breathJaundice or yellowing of the skinNausea, vomiting, or diarrheaHigh blood pressureFrequent infectionsSkin changes or new skin growthsTremors or shaking handsJoint pain or muscle achesChanges in blood sugar levelsMood changes or confusion
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsMasonic Cancer Center, University of Minnesota — PHASE2
Peking University People's Hospital — NA
Peking University People's Hospital — NA
Assistance Publique Hopitaux De Marseille
University of California, San Francisco — NA
Vanderbilt University Medical Center — EARLY_PHASE1
University Medical Center Groningen
Medical College of Wisconsin — PHASE4
The Methodist Hospital Research Institute — PHASE2
University of California, Los Angeles — PHASE4
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Complication after organ transplantation.
13 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Financial Resources
2 resourcesMycophenolate Mofetil, mycophenolate mofetil
Roche
Organ Transplant
MYCOPHENOLATE MOFETIL
Roche
Organ Transplant
Travel Grants
No travel grants are currently matched to Complication after organ transplantation.
Community
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Start the conversation →Latest news about Complication after organ transplantation
Disease timeline:
New recruiting trial: A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases
A new clinical trial is recruiting patients for Complication after organ transplantation
New recruiting trial: NRP vs DHOPE vs COR-NMP in ECD-DCD Donation
A new clinical trial is recruiting patients for Complication after organ transplantation
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What type of rejection am I most at risk for, and how will you monitor for it?,What are the side effects of my immunosuppressive medications, and what should I report immediately?,How often will I need blood tests and follow-up visits?,Are there any foods, drinks, or over-the-counter medications I need to avoid?,What signs of infection should I watch for, and when should I go to the emergency room?,How will my cancer risk be monitored over time?,When can I return to work, school, or physical activities?
Common questions about Complication after organ transplantation
What is Complication after organ transplantation?
Complications after organ transplantation refer to a range of medical problems that can happen after a person receives a transplanted organ, such as a kidney, liver, heart, lung, or other organ. These complications are not caused by a single gene or inherited condition, but rather arise from the complex interaction between the transplanted organ and the recipient's body. The most common issue is organ rejection, where the body's immune system attacks the new organ because it recognizes it as foreign. To prevent this, patients must take immunosuppressive medications, which lower the immune syst
How is Complication after organ transplantation inherited?
Complication after organ transplantation follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Are there clinical trials for Complication after organ transplantation?
Yes — 13 recruiting clinical trials are currently listed for Complication after organ transplantation on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Complication after organ transplantation?
8 specialists and care centers treating Complication after organ transplantation are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.
What treatment and support options exist for Complication after organ transplantation?
2 patient support programs are currently tracked on UniteRare for Complication after organ transplantation. See the treatments and support programs sections for copay assistance, eligibility, and contact details.