Overview
Chondromyxoid fibroma (CMF) is a rare, benign (non-cancerous) bone tumor. It is one of the least common bone tumors, making up less than 1% of all bone tumors. Despite being benign, it can cause significant discomfort and problems depending on where it grows. The tumor is made up of a mix of cartilage-like tissue and a jelly-like substance called myxoid tissue, along with fibrous tissue. Chondromyxoid fibroma most often develops in the long bones of the legs, particularly the tibia (shinbone) and the bones around the knee. However, it can also appear in the pelvis, foot bones, and other locations. The most common symptom is a dull, aching pain in the affected area that may gradually worsen over time. Some people notice swelling or a firm lump near the tumor. In some cases, the tumor weakens the bone enough to cause a fracture with minimal injury. This tumor is most frequently diagnosed in teenagers and young adults, typically between the ages of 10 and 30. Males are slightly more often affected than females. The main treatment is surgery to remove the tumor. While chondromyxoid fibroma does not spread to other parts of the body, it can come back after surgery in some cases, so follow-up monitoring is important. The overall outlook is very good, as this is a benign condition with excellent survival rates.
Key symptoms:
Dull or aching bone painSwelling near the affected boneA firm lump or mass that can be feltPain that worsens over timeLimited movement in a nearby jointTenderness when pressing on the areaBone fracture from minor injury (pathologic fracture)Stiffness in the affected limbLimping or difficulty walking if the leg is affectedMuscle weakness near the tumor
Sporadic
Usually appears on its own, not inherited from a parent
Juvenile
Begins in the teen years
Treatments
No FDA-approved treatments are currently listed for Chondromyxoid fibroma.
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View all trials with filters →No actively recruiting trials found for Chondromyxoid fibroma at this time.
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Specialists
View all specialists →No specialists are currently listed for Chondromyxoid fibroma.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Chondromyxoid fibroma.
Community
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Caregiver Resources
NORD Caregiver Resources
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Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is the exact location and size of the tumor, and how does that affect my treatment options?,What type of surgery do you recommend — curettage or wider excision — and why?,What is the expected recurrence rate with the recommended surgical approach?,How long will recovery take, and will I need physical therapy afterward?,How often will I need follow-up imaging to check for recurrence?,Are there any activity restrictions I should follow before or after surgery?,Could this tumor be anything other than a chondromyxoid fibroma, and how will you confirm the diagnosis?
Common questions about Chondromyxoid fibroma
What is Chondromyxoid fibroma?
Chondromyxoid fibroma (CMF) is a rare, benign (non-cancerous) bone tumor. It is one of the least common bone tumors, making up less than 1% of all bone tumors. Despite being benign, it can cause significant discomfort and problems depending on where it grows. The tumor is made up of a mix of cartilage-like tissue and a jelly-like substance called myxoid tissue, along with fibrous tissue. Chondromyxoid fibroma most often develops in the long bones of the legs, particularly the tibia (shinbone) and the bones around the knee. However, it can also appear in the pelvis, foot bones, and other locat
How is Chondromyxoid fibroma inherited?
Chondromyxoid fibroma follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Chondromyxoid fibroma typically begin?
Typical onset of Chondromyxoid fibroma is juvenile. Age of onset can vary across affected individuals.