Addison disease

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ORPHA:85138OMIM:103230E27.1
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1FDA treatments1Active trials34Specialists8Treatment centers1Financial resources

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ℹ
UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Also known as:

Primary Addison diseaseAutoimmune adrenalitisClassic Addison diseaseAutoimmune Addison diseasePrimary adrenal insufficiency

Clinical phenotype terms— hover any for plain English:

Salt cravingHP:0030083Thiamine-responsive megaloblastic anemiaHP:0004860Primary testicular failureHP:0008720ThymomaHP:0100522Increased circulating ACTH levelHP:0003154Renal salt wastingHP:0000127Increased circulating renin concentrationHP:0000848Normocytic anemiaHP:0001897
Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

7 events
Feb 2026Telehealth Music Therapy for Adults With Endocrine Disorder and Depression

Appalachian State University — NA

TrialNOT YET RECRUITING
Jan 2026Risks of Ramadan Fasting in Patients With Primary Adrenal Insufficiency Treated With Prednisolone.

Hopital La Rabta — NA

TrialNOT YET RECRUITING
Dec 2025Remdesivir for the Treatment of Upper Respiratory Tract Infection Due to RSV in Immunocompromised Individuals

Fred Hutchinson Cancer Center — PHASE2

TrialRECRUITING
Jun 2025Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders

University of Sao Paulo General Hospital — NA

TrialNOT YET RECRUITING
May 2025

Hydrocortisone: FDA approved

replacement therapy in pediatric patients 5 years of age and older with adrenocortical insufficiency

FDAcompleted
Jan 2025Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion

Qifu Li

TrialRECRUITING
Jan 2019Effects of Anakinra in Subjects With Corticosteroid-resistant/Intolerant Meniere's Disease and Autoimmune Inner Ear Disease

Northwell Health — PHASE2

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

1 available

Hydrocortisone

HYDROCORTISONE· Preferred Pharmaceuticals Inc.Orphan Drug

replacement therapy in pediatric patients 5 years of age and older with adrenocortical insufficiency

View Details →FDA Label ↗Copay Card ↗Patient Assistance ↗

Clinical Trials

1 recruitingView all trials with filters →
Other1 trial
Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion
Actively Recruiting
· Sites: Chongqing, Chongqing Municipality · Age: 18–70 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

Showing 25 of 34View all specialists →
SM
Stefanie Hahner, MD
Specialist
PI on 2 active trials
GP
Gudmundur Johannsson, Professor
Specialist
PI on 2 active trials2 Addison disease publications
PM
Paal Methlie, MD
Specialist
PI on 1 active trial
VP
Valentina Morelli, PHD
Specialist
PI on 1 active trial
BM
Bruno Allolio, MD
Specialist
PI on 5 active trials
RR
R Ross
Specialist
PI on 1 active trial91 Addison disease publications
SP
Stefanie Hahner, MD, Prof.
Specialist
PI on 3 active trials
JP
Julie D Saba, MD, PhD
OAKLAND, CA
Specialist
PI on 2 active trials
MB
Maria Forss, MSc BA
Specialist
PI on 1 active trial9 Addison disease publications
AP
Andrea M Isidori, MD, PhD
Specialist
PI on 5 active trials
AP
Anna G Nilsson, MD, PhD
Specialist
PI on 1 active trial
KP
Kristian Løvås, MD, PhD
Specialist
PI on 4 active trials
KM
Kristian Løvås, MD,PhD
Specialist
PI on 1 active trial
AM
Andrea Vambutas, MD
New Hyde Park, New York
Specialist

Rare Disease Specialist

PI on 3 active trials1 Addison disease publication
AM
Angela Duker, MS
WILMINGTON, DE
Specialist
PI on 1 active trial
KP
Katerina Simunkova, MD, PhD
Specialist
PI on 1 active trial
EM
Ernst A Lien, Prof. MD.
Specialist
PI on 1 active trial
MM
Markus Weber, MD
Specialist
PI on 1 active trial
EM
Eystein S Husebye, Prof, MD
Specialist
PI on 1 active trial
GM
Gudmundur Johannsson, Prof., MD
Specialist
PI on 1 active trial
SM
Simon H Pearce, MD
Specialist
PI on 1 active trial
JP
Jens Juel Christiansen, PhD
Specialist
PI on 1 active trial
MP
Marianne Grytaas, MD phd
Specialist
PI on 1 active trial
MP
Mirjam Christ-Crain, Professor
Specialist
PI on 1 active trial
SP
Stephan M Jakob, Professor
Specialist
PI on 1 active trial

Treatment Centers

8 centers
⚗️ Trial Site

Fred Hutch/University of Washington Cancer Consortium

📍 Seattle, Washington

👤 Rosa Nadal Rios, MD, PhD

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

Financial Resources

1 resources
Hydrocortisone(HYDROCORTISONE)— Preferred Pharmaceuticals Inc.

Travel Grants

No travel grants are currently matched to Addison disease.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Addison disease

5 articles
NewsRSSApr 24, 2026
Words of wisdom for living well with Parkinson’s disease
A person with Parkinson's disease shares their experience living well with the condition after receiving deep brain stimulation surgery. They started a weekly w…
Clinical trialRSSApr 24, 2026
AAN 2026: Tavapadon helps delay levodopa start in early Parkinson’s
A new experimental drug called tavapadon from AbbVie helped people with early Parkinson's disease delay or avoid starting levodopa, which is the standard treatm…
NewsRSSApr 24, 2026
Parkinson’s psychosis and UTIs: Is there a connection?
Some people with Parkinson's disease experience hallucinations or false beliefs, which is called psychosis. However, sudden changes in thinking or behavior migh…
Clinical trialRSSApr 23, 2026
AAN 2026: VQ-101 reaches the brain, hits target in diverse Parkinson’s patients
Scientists tested a new pill called VQ-101 that can enter the brain and increase levels of a protective protein in people with Parkinson's disease. In early tes…
Clinical trialRSSApr 22, 2026
AAN 2026: Parkinson’s cell therapy trial shows sustained benefits
A company called BlueRock Therapeutics tested a new cell therapy called bemdaneprocel for Parkinson's disease. In a small early-stage trial, patients who receiv…
See all news about Addison disease →

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Addison disease

Are there clinical trials for Addison disease?

Yes — 1 recruiting clinical trial is currently listed for Addison disease on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Addison disease?

25 specialists and care centers treating Addison disease are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.