Small cell lung cancer

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At a Glance

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Regulatory Watchboard

10 events
Sep 2026A Study of Alisertib and Paclitaxel in Patients With Small Cell Lung Cancer (SCLC)

Puma Biotechnology, Inc. — PHASE2

TrialNOT YET RECRUITING
May 2026Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation

University Health Network, Toronto — PHASE2

TrialNOT YET RECRUITING
May 2026Limertinib Plus Carboplatin and Etoposide for EGFR-mutant NSCLC With SCLC Transformation After EGFR-TKI Progression

Hunan Province Tumor Hospital — PHASE2

TrialNOT YET RECRUITING
May 2026A First-in-human (FIH), Phase 1 Study of ML261, an Autologous Potency Enhanced Anti-DLL3 CAR T Cell Therapy, in Participants With R/R SCLC or Select NECs

Moonlight Bio, Inc — PHASE1

TrialNOT YET RECRUITING
May 2026DK222 Study at Hopkins

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — PHASE1

TrialNOT YET RECRUITING
Apr 2026SHR-A1811 + AK112 in HER2-Altered Advanced/Metastatic NSCLC

Sun Yat-sen University — PHASE2

TrialNOT YET RECRUITING
Apr 2026Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)

National Cancer Institute (NCI) — PHASE1, PHASE2

TrialNOT YET RECRUITING
Apr 2026Bispecific T-Cell Engager Tarlatamab and TROP2 Targeted Antibody Drug Conjugate Sacituzumab Govitecan in Previously Treated Extensive-Stage Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer

National Cancer Institute (NCI) — PHASE1, PHASE2

TrialNOT YET RECRUITING
Mar 2026Predicting Response to Anti-PD-1/PD-L1 Immunotherapy by Plasma Extracellular Vesicle Analysis

Centre Georges Francois Leclerc

TrialNOT YET RECRUITING
Feb 2026ZEPZELCA: New indication approved
FDAcompleted

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

10 programs

FINANCIAL LANDSCAPE SUMMARY

10

Total programs

10

Open now

1

Copay cards

Copay Assistance1

Imdelltra

Amgen Inc.

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Patient Assistance Programs9

Tagrisso

AstraZeneca Pharmaceuticals LP

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IMFINZI

AstraZeneca Pharmaceuticals LP

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TECENTRIQ

Genentech, Inc.

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Gilotrif

Boehringer Ingelheim Pharmaceuticals, Inc.

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KRAZATI

Mirati Therapeutics, Inc

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Braftovi

Array BioPharma Inc. (a wholly owned subsidiary of Pfizer Inc.)

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Imjudo

AstraZeneca Pharmaceuticals LP

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CYRAMZA

Eli Lilly and Company

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Zepzelca

Jazz Pharmaceuticals Ireland Limited

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View all support programs on disease page →

Approved Treatments

8 FDA-approved

Zepzelca

(lurbinectedin)Orphan drug

Jazz Pharmaceuticals Ireland Limited

Alkylating Drug [EPC]

12.1 Mechanism of Action Lurbinectedin is an alkylating drug that binds guanine residues in the minor groove of DNA, forming adducts and resulting in ...

Approved Oct 2025FDA label ↗

Imdelltra

(tarlatamab-dlle)Orphan drug

Amgen Inc.

12.1 Mechanism of Action Tarlatamab-dlle is a bispecific T-cell engager that binds to DLL3 expressed on the surface of cells, including tumor cells, a...

Approved May 2024FDA label ↗

TECENTRIQ

(atezolizumab)Orphan drug

Genentech, Inc.

Programmed Death Receptor-1 Blocking Antibody [EPC]

12.1 Mechanism of Action PD L1 may be expressed on tumor cells and/or tumor infiltrating immune cells and can contribute to the inhibition of the anti...

Approved Mar 2019FDA label ↗

OPDIVO

(NIVOLUMAB)standard

E.R. Squibb & Sons, L.L.C.

Programmed Death Receptor-1 Blocking Antibody [EPC]

12.1 Mechanism of Action Binding of the PD-1 ligands, PD-L1 and PD-L2, to the PD-1 receptor found on T cells, inhibits T-cell proliferation and cytoki...

FDA label ↗

Tagrisso

(osimertinib)Orphan drugstandard

AstraZeneca Pharmaceuticals LP

Kinase Inhibitor [EPC]

12.1 Mechanism of Action Osimertinib is a kinase inhibitor of the epidermal growth factor receptor (EGFR), which binds irreversibly to certain mutant ...

FDA label ↗

Abraxane

(paclitaxel protein-bound particles)Orphan drugstandard

Abraxis BioScience, LLC

Microtubule Inhibitor [EPC]

12.1 Mechanism of Action ABRAXANE is a microtubule inhibitor that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubule...

FDA label ↗

KRAZATI

(ADAGRASIB)accelerated

Mirati Therapeutics, Inc

12.1 Mechanism of Action Adagrasib is an irreversible inhibitor of KRAS G12C that covalently binds to the mutant cysteine in KRAS G12C and locks the m...

FDA label ↗

Imjudo

(tremelimumab-actl)Orphan drugstandard

AstraZeneca Pharmaceuticals LP

CTLA-4-directed Blocking Antibody [EPC]

12.1 Mechanism of Action CTLA-4 is a negative regulator of T-cell activity. Tremelimumab-actl is a monoclonal antibody that binds to CTLA-4 and blocks...

FDA label ↗

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Clinical Trial Landscape

188 active trials
23Phase 3
1Phase 4
44Phase 2
51Phase 1
12N/A
19Unknown
34PHASE1, PHASE2
3PHASE2, PHASE3
1EARLY_PHASE1
188Total recruiting
Search clinical trials for Small cell lung cancer

Recent News & Research

6 articles
Cancer biology & medicineApr 22, 2026

Opportunities and challenges of immunotherapy for patients with resectable and potentially resectable stage III non-small cell lung cancer.

The integration of immune checkpoint inhibitors has transformed the therapeutic landscape for patients with resectable and potentially resectable stage III non-small cell lung cancer, providing unprec...

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Critical reviews in oncology/hematologyApr 22, 2026

Mapping the immune microenvironment of non-small cell lung cancer.

Immunotherapy is widely used in non-small cell lung cancer (NSCLC) treatment due to its significant efficacy. However, heterogeneity in treatment efficacy persists as a major challenge. The tumor immu...

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Journal of patient-centered research and reviewsApr 21, 2026

Cryoablation as a Treatment Option for Early-Stage Primary Non-Small Cell Lung Cancer and Lung Metastases: A Narrative Review of Recent Literature.

Cryoablation has emerged as a promising treatment option for early-stage non-small cell lung cancer (NSCLC) and lung metastases. This narrative review examines recent literature on cryoablation's effi...

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Cancer cellApr 14, 2026

Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer.

Small cell lung cancer (SCLC) typically displays a "cold" tumor microenvironment with a paucity of immune infiltrate. Neuroendocrine SCLC cells also profoundly repress MHC-I expression, rendering them...

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Frontiers in oncologyApr 13, 2026

Editorial: Treatment response and resistance to targeted therapies for NSCLC.

Editorial: Treatment response and resistance to targeted therapies for NSCLC.

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Cell host & microbeMar 12, 2026

Strain-level genetic heterogeneity and colonization dynamics drive microbiome therapeutic efficacy.

Fecal microbiota transplantation (FMT) has shown immunotherapeutic promise, yet its efficacy in non-small-cell lung cancer (NSCLC) remains unclear. We demonstrate that FMT improves anti-PD-1 efficacy ...

Read ↗

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Specialist Network

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