Hereditary angioedema

Advocacy intelligence hub — real-time data for patient organizations

View full disease page →Search clinical trials →
Download CSV

At a Glance

Live from database

Live Alerts

PAN Foundation — Hereditary angioedema status changedApply now ↗

Regulatory Watchboard

10 events
Jul 2026Donidalorsen Treatment in Children With Hereditary Angioedema

Ionis Pharmaceuticals, Inc. — PHASE3

TrialRECRUITING
May 2026A Study About the Diagnosis and Management of Hereditary Angioedema (HAE) in Egypt

Takeda

TrialNOT YET RECRUITING
May 2026A Study of Takhzyro in Teenagers and Adults With Hereditary Angioedema (HAE) in South Korea

Takeda

TrialNOT YET RECRUITING
Apr 2026A Study of Lanadelumab in Teenagers and Adults With Hereditary Angioedema (HAE) in the Kingdom of Saudi Arabia

Takeda

TrialNOT YET RECRUITING
Apr 2026A Study to Learn About the C1-Inhibitor Function as Diagnosis for Hereditary Angioedema

Takeda — NA

TrialNOT YET RECRUITING
Apr 2026Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)

ADARx Pharmaceuticals, Inc. — PHASE3

TrialNOT YET RECRUITING
Apr 2026Bleeding Reduction in Grade II-III Haemorrhoids Through Embolization Treatment

Cardiovascular and Interventional Radiological Society of Europe

TrialNOT YET RECRUITING
Feb 2026A Study of Lanadelumab in Children With Hereditary Angioedema (HAE) in Multiple Countries

Takeda — NA

TrialRECRUITING
Oct 2025Study of Oral Deucrictibant XR Tablet for Prophylaxis and Deucrictibant IR Capsule for On-Demand Treatment of Angioedema Attacks in Adults With Acquired Angioedema Due to C1 Inhibitor Deficiency

Pharvaris Netherlands B.V. — PHASE3

TrialRECRUITING
Oct 2025A Long-Term Study of Navenibart in Participants With Hereditary Angioedema

Astria Therapeutics, Inc. — PHASE3

TrialENROLLING BY INVITATION

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

19 programs

FINANCIAL LANDSCAPE SUMMARY

19

Total programs

18

Open now

$8K

Available/year

6

Foundation grants

3

Travel grants

Foundation Grants6

Good Days — Hereditary angioedema

Good Days

OpenContact for detailsApply ↗

HealthWell Foundation — Hereditary angioedema

HealthWell Foundation

OpenContact for detailsApply ↗

NORD Patient Assistance — Hereditary angioedema

NORD Patient Assistance

OpenContact for detailsApply ↗

Patient Services Inc — Hereditary angioedema

Patient Services Inc

OpenContact for detailsApply ↗

PAN Foundation — Hereditary angioedema

PAN Foundation

ClosedContact for detailsApply ↗

The Assistance Fund — Hereditary angioedema

The Assistance Fund

OpenContact for detailsApply ↗

Patient Assistance Programs10

Haegarda

CSL Behring LLC

OpenContact for details

Kalbitor

Takeda Pharmaceuticals America, Inc.

OpenContact for detailsApply ↗

SAJAZIR

Cycle Pharmaceuticals Ltd-Uk

OpenContact for details

EKTERLY

KalVista Pharmaceuticals Ltd

OpenContact for details

Danazol

Chartwell RX, LLC.

OpenContact for details

ANDEMBRY

CSL

OpenContact for details

Orladeyo

BioCryst Pharmaceuticals, Inc.

OpenContact for details

ICATIBANT

Bryant Ranch Prepack

OpenContact for details

TAKHZYRO

Takeda Pharmaceuticals America, Inc.

OpenContact for detailsApply ↗

Ruconest

Pharming Healthcare Inc.

OpenContact for details

Travel Grants3

2026 HAEi Regional Conference Travel Grant

HAE International

OpenContact for detailsApply ↗

Accessia Health: Hereditary Angioedema - Public Insurance

Accessia Health

OpenUp to $8K/yrApply ↗

Hereditary Angioedema Financial Assistance Program

The Assistance Fund

OpenContact for detailsApply ↗

View all support programs on disease page →

Approved Treatments

8 FDA-approved

SAJAZIR

(ICATIBANT)Orphan drugstandard

Cycle Pharmaceuticals Ltd-Uk

FDA label ↗

EKTERLY

(SEBETRALSTAT)Orphan drugstandard

KalVista Pharmaceuticals Ltd

FDA label ↗

Ruconest

(C1 ESTERASE INHIBITOR RECOMBINANT)Orphan drugstandard

Pharming Healthcare Inc.

FDA label ↗

Kalbitor

(ECALLANTIDE)Orphan drugstandard

Takeda Pharmaceuticals America, Inc.

FDA label ↗

Haegarda

(C1 esterase inhibitor subcutaneous (human))Orphan drugstandard

CSL Behring LLC

ANDEMBRY

(GARADACIMAB)Orphan drugstandard

CSL

FDA label ↗

Orladeyo

(berotralstat)Orphan drugstandard

BioCryst Pharmaceuticals, Inc.

12.1 Mechanism of Action Berotralstat is a plasma kallikrein inhibitor that binds to plasma kallikrein and inhibits its proteolytic activity. Plasma k...

FDA label ↗

TAKHZYRO

(LANADELUMAB-FLYO)Orphan drugstandard

Takeda Pharmaceuticals America, Inc.

FDA label ↗

View full treatment details on disease page →

Clinical Trial Landscape

27 active trials
13Phase 3
1Phase 4
2Phase 2
3Phase 1
5N/A
1Unknown
1PHASE2, PHASE3
1PHASE1, PHASE2
27Total recruiting
Search clinical trials for Hereditary angioedema

Recent News & Research

6 articles
Orphanet journal of rare diseasesApr 22, 2026

Mast cell mediators in hereditary angioedema.

Mast cell mediators in hereditary angioedema.

Read ↗
Frontiers in immunologyApr 22, 2026

Eosinophilic inflammation in hereditary angioedema: a single-center real-world retrospective chart review study.

Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent, unpredictable swelling attacks primarily driven by bradykinin-mediated vascular permeability. However, additional inf...

Read ↗
The Journal of allergy and clinical immunologyApr 5, 2026

Updates in hereditary angioedema and chronic spontaneous urticaria.

Hereditary angioedema (HAE) is a genetic disorder caused by either deficiency of C1 esterase inhibitor (85% of cases) or normal to high levels of nonfunctional C1 esterase inhibitor. Both defects lead...

Read ↗
Cardiology in reviewMar 20, 2026

Hereditary Angioedema.

Hereditary angioedema is a rare and disabling disorder caused by mutations in the SERPING1 gene. These mutations ultimately lead to deficient or dysfunctional C1 esterase inhibitor and unregulated act...

Read ↗
Allergy and asthma proceedingsMar 17, 2026

Rethinking the management of hereditary angioedema.

Background: Hereditary angioedema with C1INH deficiency (HAE-C1INH) is a rare, debilitating genetic disorder characterized by recurrent, unpredictable attacks. Although treatments exist, patients with...

Read ↗
Frontiers in immunologyMar 13, 2026

Epidemiological and clinical characteristics of hereditary angioedema in the Baltic states.

Hereditary angioedema (HAE) is a rare, potentially life-threatening disorder characterised by recurrent episodes of localised oedema caused by bradykinin overproduction. Accurate epidemiological data ...

Read ↗

Browse all Hereditary angioedema news →

Specialist Network

Top 6 by expertise

View all Hereditary angioedema specialists →

Quick Actions