RecruitingPhase 3NCT05230758

Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour

Studying Medulloblastoma

Last synced from ClinicalTrials.gov April 1, 2026

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Key facts

Sponsor: Donald Mabbott
Principal Investigator: Donald Mabbott, Ph.D.
The Hospital for Sick Children
Intervention: Metformin hydrochloride (HCl) 500mg tablet(drug)
Enrollment: 140 target
Eligibility: 7-21 years · All sexes
Timeline: 2022 – 2027

Study locations (20)

John Hunter Children's Hospital, New Lambton Heights, New South Wales, Australia
Children's Hospital in Westmead, Westmead, New South Wales, Australia
Women and Childen's Hospital, Adelaide, North Adelaide, Australia
Monash Children's Hospital, Clayton, Victoria, Australia
Royal Children's Hospital, Parkville, Victoria, Australia
Perth Children's Hospital, Nedlands, Western Australia, Australia
Alberta Children's Hospital, Calgary, Alberta, Canada
Stollery Children's Hospital, Edmonton, Alberta, Canada
Children's & Women's Health Centre of British Columbia, Vancouver, British Columbia, Canada
Cancer Care Manitoba, Winnipeg, Manitoba, Canada
Izaak Walton Killam (IWK) Health Centre, Halifax, Nova Scotia, Canada
Hamilton Health Sciences - McMaster Children's Hospital, Hamilton, Ontario, Canada
Children's Hospital, London Health Sciences Centre, London, Ontario, Canada
Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada
The Hospital for Sick Children, Toronto, Ontario, Canada
+5 more locations on ClinicalTrials.gov

Primary source

Recruitment status, site addresses, contacts, and full eligibility criteria can change between syncs. Always verify with the trial team before planning travel or treatment.

Open NCT05230758 on ClinicalTrials.gov

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