TerminatedPHASE1, PHASE2NCT05154890
A Multiple Ascending Dose Study of ACN00177 (Pegtarviliase) in Subjects With CBS Deficiency
Studying Homocystinuria
Last synced from ClinicalTrials.gov
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Clinical trial records are synced from ClinicalTrials.gov through automated extraction.
Report missing dataKey facts
- Sponsor
- Aeglea Biotherapeutics
- Principal Investigator
- Cortney Caudill, LCSWAeglea Biotherapeutics
- Intervention
- Pegtarviliase IV(drug)
- Enrollment
- 13 enrolled
- Eligibility
- 12 years · All sexes
- Timeline
- 2021 – 2023
Study locations (9)
- UT Southwestern Medical Center, Dallas, Texas, United States
- Westmead Hospital, Westmead, New South Wales, Australia
- Royal Children's Hospital, Parkville, Victoria, Australia
- Royal Melbourne Hospital, Parkville, Victoria, Australia
- University Hospitals Birmingham NHS, Birmingham, United Kingdom
- Great Ormond Street Hospital, London, United Kingdom
- Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom
- University College London, London, United Kingdom
- Salford Royal NHS Foundation Trust, Salford, United Kingdom
Primary source
Recruitment status, site addresses, contacts, and full eligibility criteria can change between syncs. Always verify with the trial team before planning travel or treatment.
Open NCT05154890 on ClinicalTrials.govOther trials for Homocystinuria
Additional recruiting or active studies for the same condition.
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- ACTIVE NOT RECRUITINGNANCT06495567Proof of Concept Creatine Supplementation for Homocystinuria StudyUniversity of British Columbia
- ENROLLING BY INVITATIONPHASE3NCT06431893A Phase 3 Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)Travere Therapeutics, Inc.
- ACTIVE NOT RECRUITINGPHASE3NCT06247085A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care TreatmentTravere Therapeutics, Inc.
- ACTIVE NOT RECRUITINGPHASE1, PHASE2NCT03406611Pegtibatinase As an Enzyme Therapy for Patients with Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (COMPOSE)Travere Therapeutics, Inc.
- RECRUITINGNCT02998710Natural History Study of Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (ACAPPELLA)Travere Therapeutics, Inc.