ResearchPUBMEDMay 12
VUStruct: A compute pipeline for high throughput and personalized structural biology.
Scientists created a new computer tool called VUStruct that helps doctors understand genetic mutations found in patients with rare diseases. Instead of just looking at DNA sequences, this tool examines how mutations affect the actual 3D shape and function of proteins in the body. By combining genetic data with protein structure information and artificial intelligence, VUStruct helps doctors figure out which genetic changes are actually causing disease.
WHY IT MATTERSIf you or a family member has been told they have a genetic variant of unknown significance (VUS), VUStruct could help your doctor determine whether that variant is actually causing your rare disease or if it's harmless.
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