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2 articles matching "amniotic fluid"

ResearchCLINICALTRIALSMar 27

Trial Now Recruiting: Characterization and Contribution of Genome-wide DNA Methylation (DNA Methylation Episignatures) in Rare Diseases With Prenatal Onset (NCT06475651)

Researchers are looking for 63 participants to help them understand how DNA changes in babies before birth compare to DNA changes after birth. They want to collect DNA from amniotic fluid (the fluid around a baby in the womb) or from tissue samples after delivery to create a reference guide. This guide will help doctors better diagnose rare genetic diseases that start before birth.

WHY IT MATTERSThis trial could improve how doctors diagnose rare genetic diseases in fetuses and newborns by establishing what normal DNA patterns look like before birth, which is currently unknown.
→ You can act on thisRare Fetal Genetic DiseasesCongenital MalformationRead →
Clinical trialCLINICALTRIALSMar 26

Trial Now Recruiting: Human Amniotic-Derived Mesenchymal Stem Cell Therapy for Calciphylaxis (NCT04592640)

Researchers are testing a new treatment for calciphylaxis, a serious condition where calcium builds up in blood vessels and skin tissue, causing painful sores. The treatment uses special cells from amniotic fluid (the fluid around a baby during pregnancy) to see if they can help heal the damage. This is an early-stage trial with a small group of 9 patients to check if the treatment is safe and works.

WHY IT MATTERSCalciphylaxis has very few treatment options and high mortality rates — this trial offers patients with chronic kidney disease a chance to access an experimental stem cell therapy that could reduce tissue damage and improve survival.
→ You can act on thisCalciphylaxisCalcific Uremic ArteriolopathyChronic Kidney DiseaseRead →

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