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2 articles from the last 30 days matching "heart disease"

ResearchBIORXIVYesterday

Preprint: Fasting reverses PLN R14del-mediated cardiomyopathy through lysosomal reactivation

Scientists discovered that fasting may help reverse heart damage caused by a specific genetic mutation in the PLN gene called R14del. This mutation causes a common type of inherited heart disease where abnormal protein clumps build up in heart cells. The research shows that fasting activates the cell's cleanup system (lysosomes) to remove these harmful clumps and restore heart function.

WHY IT MATTERSIf confirmed in human studies, fasting could offer PLN R14del cardiomyopathy patients a non-drug intervention to potentially reverse heart damage, though this is currently only demonstrated in laboratory research and requires clinical validation.
👁 Watch this spacePLN R14del cardiomyopathydilated cardiomyopathyarrhythmogenic cardiomyopathyRead →
ResearchPUBMEDMar 28

Rare and emerging arterial diseases of the supra-aortic trunks: Diagnostic and therapeutic insights.

This article discusses rare diseases that affect the major blood vessels in the neck and upper chest (called supra-aortic trunks). While most blockages in these vessels are caused by common heart disease risk factors, about 10% happen in people without those risk factors. The article highlights three newly recognized conditions: TIPIC syndrome (temporary inflammation around the carotid artery), carotid web (an unusual narrowing), and Eagle syndrome (a bone growth problem). Better imaging technology is helping doctors identify these rare conditions more accurately.

WHY IT MATTERSIf you have unexplained neck pain, stroke symptoms, or carotid artery narrowing without typical heart disease risk factors, your doctor may now consider these emerging diagnoses instead of assuming standard atherosclerosis.
💬 Ask your doctorTransient Perivascular Inflammation of the Carotid artery (TIPIC) syndromeCarotid webEagle syndromeRead →

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