New Clinical Trial: Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic (NCT02726711)
WHY IT MATTERS
This trial directly addresses a poorly understood cause of high blood pressure in patients with Multiple System Atrophy and related autonomic nervous system disorders, potentially leading to better treatment options for this hard-to-manage symptom.
Researchers at Vanderbilt University are studying how the nervous system controls blood vessels in the abdomen and how this might cause high blood pressure in people with certain rare nervous system disorders. The study focuses on three conditions where the nervous system doesn't work properly: Multiple System Atrophy, Orthostatic Hypotension, and Supine Hypertension. By understanding this connection, doctors may find new ways to treat high blood pressure in these patients.
NCT ID: NCT02726711 Status: ACTIVE_NOT_RECRUITING Conditions: Multiple System Atrophy, Orthostatic Hypotension, Supine Hypertension Phase: PHASE1 Enrollment: 2 Sponsor: Vanderbilt University Summary: The purpose of this study is to learn more about the regulation of the veins of the abdomen by the autonomic (involuntary) nervous system, and how this may affect high blood pressure. Normally, the autonomic nervous system controls how much blood flows in the veins. In people with high blood pressure, however, the autonomic nervous system is changed. This change may affect the way blood flows in the veins of the abdomen which may play a role in their high blood pressure. About 32 participants wi