Protein changes may help explain Spinraza response in SMA
WHY IT MATTERS
Understanding which protein changes in cerebrospinal fluid predict Spinraza response could help doctors identify which SMA patients are most likely to benefit from treatment and potentially guide future treatment decisions.
Researchers studied how Spinraza, a medicine for spinal muscular atrophy (SMA), changes certain proteins in the fluid around the brain and spinal cord. They found that these protein changes happen when the medicine works, and some of these changes match up with patients getting stronger and moving better. This helps doctors understand why the medicine helps some patients.
Treatment with Spinraza (nusinersen) was linked to measurable changes in a range of cerebrospinal fluid (CSF) biomarkers in people with spinal muscular atrophy (SMA), some of which were associated with improvements in motor function, according to a review of published studies. Among the protein changes seen in CSF, the liquid that surrounds the brain and […] The post Protein changes may help explain Spinraza response in SMA appeared first on SMA News Today .
ASK YOUR DOCTOR
If you or your child is currently on Spinraza or considering it, ask your neurologist whether CSF biomarker testing might be available to help monitor treatment response.