Preprint: Sex-Stratified Multi-Omics Identifies Sexually Dimorphic Molecular Targets in Parkinsons Disease
WHY IT MATTERS
Understanding sex-specific causes of Parkinson's disease could enable doctors to develop targeted treatments that work better for men or women individually, rather than using one-size-fits-all approaches.
Researchers studied how Parkinson's disease affects men and women differently by examining genetic and protein data from thousands of patients. They found that certain genes and biological pathways that cause Parkinson's work differently in males versus females, which could explain why men and women experience this disease differently. This discovery could lead to treatments designed specifically for each sex.
Sex-Stratified Multi-Omics Identifies Sexually Dimorphic Molecular Targets in Parkinsons Disease Authors: Lee, J.-Y. et al. Server: medRxiv Category: genetic and genomic medicine Abstract: Parkinsons disease (PD) exhibits well-established sex differences in prevalence and clinical phenotypes, yet the underlying molecular mechanisms remain largely elusive. Here, we conducted a comprehensive sex-stratified multi-omic integration to identify sex-specific causal proteins and biological pathways in PD. We performed gene-based association analysis, transcriptome-wide association studies (TWAS), and proteome-wide Mendelian randomization (PWMR) with colocalization analysis using GWAS summary statistics from the International PD Genetics Consortium (IPDGC; 12,054 male cases/11,999 contr