Trial Completed: Genetic Studies in the Amish and Mennonites (NCT00359580)

WHY IT MATTERS

This completed research provides a genetic foundation for understanding rare inherited disorders in Amish and Mennonite populations, which could lead to earlier diagnosis and better treatment options for affected families in these communities.

Researchers completed a study with 157 Amish and Mennonite participants to find the genes that cause inherited diseases common in these communities. They also created a family tree database using birth and marriage records to help understand how these genetic diseases run in families and what health problems develop over time.

NCT ID: NCT00359580 Status: COMPLETED Conditions: Genetic Disease Enrollment: 157 Sponsor: National Human Genome Research Institute (NHGRI) Summary: The purposes of this study are to identify the genes responsible for several inherited disorders commonly seen in the Amish and Mennonite populations and learn more about the natural history (medical problems that develop over time) of these disorders. In addition, researchers will establish a computer database containing Amish genealogies, derived largely from the community s extensive records of births, marriages, deaths, etc., that will help construct pedigrees (family trees) for genetic stud