Overview
X-linked intellectual disability, Gu type (also known as XLID Gu type or Gu syndrome) is an extremely rare genetic condition that primarily affects males. It is caused by a mutation on the X chromosome and leads to intellectual disability along with other developmental and physical features. Because it follows an X-linked pattern, boys and men are more severely affected, while females who carry the gene change may have milder symptoms or no symptoms at all. The condition is characterized by moderate to severe intellectual disability, meaning affected individuals have significant difficulties with learning, reasoning, and adaptive behavior from early childhood. Additional features that have been described include short stature, distinctive facial features, and sometimes behavioral challenges. Because so few cases have been reported in the medical literature, the full range of symptoms and their severity is not completely understood. There is currently no cure for X-linked intellectual disability, Gu type. Treatment focuses on supportive care, including special education programs, speech and language therapy, occupational therapy, and behavioral support. Early intervention services can help affected children reach their fullest potential. Families benefit from working closely with a team of specialists to address the various needs of the affected individual.
Also known as:
Key symptoms:
Intellectual disability (moderate to severe)Delayed speech and language developmentShort statureDistinctive facial featuresDelayed motor milestones (sitting, walking)Learning difficultiesBehavioral challengesPoor coordinationDifficulty with daily living skills
X-linked recessive
Carried on the X chromosome; typically affects males more than females
Infantile
Begins in infancy, roughly 1 month to 2 years old
Treatments
No FDA-approved treatments are currently listed for X-linked intellectual disability, Gu type.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for X-linked intellectual disability, Gu type at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for X-linked intellectual disability, Gu type.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to X-linked intellectual disability, Gu type.
Community
No community posts yet. Be the first to share your experience with X-linked intellectual disability, Gu type.
Start the conversation →Latest news about X-linked intellectual disability, Gu type
No recent news articles for X-linked intellectual disability, Gu type.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is the specific genetic change causing my child's condition, and can it be identified through testing?,What therapies and early intervention services do you recommend starting right away?,How severe is the intellectual disability likely to be, and what level of independence can we expect?,Are there any other medical issues we should screen for in connection with this diagnosis?,Should other family members, especially females, be tested to see if they carry the gene change?,What educational resources and support programs are available in our area?,Are there any clinical trials or research studies we should know about?
Common questions about X-linked intellectual disability, Gu type
What is X-linked intellectual disability, Gu type?
X-linked intellectual disability, Gu type (also known as XLID Gu type or Gu syndrome) is an extremely rare genetic condition that primarily affects males. It is caused by a mutation on the X chromosome and leads to intellectual disability along with other developmental and physical features. Because it follows an X-linked pattern, boys and men are more severely affected, while females who carry the gene change may have milder symptoms or no symptoms at all. The condition is characterized by moderate to severe intellectual disability, meaning affected individuals have significant difficulties
How is X-linked intellectual disability, Gu type inherited?
X-linked intellectual disability, Gu type follows a x-linked recessive inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does X-linked intellectual disability, Gu type typically begin?
Typical onset of X-linked intellectual disability, Gu type is infantile. Age of onset can vary across affected individuals.