Verrucous hemangioma

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Overview

Verrucous hemangioma is a rare vascular skin condition that is present at birth or appears in early childhood. Despite its name, it is not a true hemangioma (a common type of blood vessel growth in babies that usually goes away on its own). Instead, verrucous hemangioma is a vascular malformation, meaning it is an abnormal formation of blood vessels that does not shrink over time and tends to grow as the child grows. The condition typically appears as a dark red, blue, or purple patch or raised area on the skin, most often on the legs or feet. Over time, the surface of the lesion becomes rough, thick, and wart-like (verrucous), which is how it gets its name. The lesion can sometimes bleed, become infected, or cause pain. Unlike infantile hemangiomas, verrucous hemangiomas do not go away on their own and tend to slowly expand and thicken throughout life. Treatment can be challenging because the abnormal blood vessels extend deep into the skin and underlying tissue. Surgical removal is the most common approach, but recurrence after surgery is frequent because the deeper parts of the lesion are difficult to remove completely. Laser therapy, sclerotherapy (injecting a solution to shrink blood vessels), and combination approaches may also be used. Early and accurate diagnosis is important because verrucous hemangioma is often confused with other vascular or skin conditions, and delayed treatment can lead to larger, harder-to-treat lesions.

Key symptoms:

Dark red, blue, or purple skin patch present at birth or early childhoodRough, wart-like (verrucous) surface that develops over timeThickened, raised skin lesion that grows with the childLesions most commonly on the legs or feetOccasional bleeding from the lesionSkin infections at the site of the lesionPain or tenderness in the affected areaDarkening of the lesion over timeCrusting or scaling on the surface of the lesionCosmetic concerns due to the appearance of the lesion

Clinical phenotype terms (7)— hover any for plain English
Regional abnormality of skinHP:0011356PapillomaHP:0012740Hyperkeratotic papuleHP:0045059
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Neonatal

Begins at or shortly after birth (first 4 weeks)

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Verrucous hemangioma.

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No actively recruiting trials found for Verrucous hemangioma at this time.

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No specialists are currently listed for Verrucous hemangioma.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Verrucous hemangioma.

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Community

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Latest news about Verrucous hemangioma

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Caregiver Resources

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Questions for your doctor

Bring these to your next appointment

  • Q1.Is this definitely verrucous hemangioma, and how was it distinguished from other similar conditions?,How deep does the lesion extend, and will imaging be needed before treatment?,What treatment approach do you recommend, and what are the chances of recurrence?,How often should we schedule follow-up visits to monitor the lesion?,Are there any signs we should watch for that would require urgent medical attention?,Will my child need multiple treatments over time?,Are there any clinical trials or newer treatments being studied for this condition?

Common questions about Verrucous hemangioma

What is Verrucous hemangioma?

Verrucous hemangioma is a rare vascular skin condition that is present at birth or appears in early childhood. Despite its name, it is not a true hemangioma (a common type of blood vessel growth in babies that usually goes away on its own). Instead, verrucous hemangioma is a vascular malformation, meaning it is an abnormal formation of blood vessels that does not shrink over time and tends to grow as the child grows. The condition typically appears as a dark red, blue, or purple patch or raised area on the skin, most often on the legs or feet. Over time, the surface of the lesion becomes roug

How is Verrucous hemangioma inherited?

Verrucous hemangioma follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Verrucous hemangioma typically begin?

Typical onset of Verrucous hemangioma is neonatal. Age of onset can vary across affected individuals.