Overview
Vegetative pyoderma gangrenosum is a rare and unusual form of pyoderma gangrenosum, a skin condition that causes painful sores (ulcers) to develop on the skin. Unlike the more common forms of pyoderma gangrenosum, the vegetative type tends to be milder and more localized. It usually appears as a single, slowly growing wound that has a warty or bumpy surface with a raised border. The sores most often show up on the trunk (the chest, belly, or back) and tend not to spread as aggressively as other types. This condition belongs to a group of skin disorders called neutrophilic dermatoses, meaning the immune system sends too many white blood cells (called neutrophils) to the skin, causing damage and ulceration. The exact cause is not fully understood, but it is often linked to problems with the immune system. In some people, it is associated with other conditions like inflammatory bowel disease or blood disorders. Treatment usually involves medicines that calm the immune system, such as corticosteroids or other immunosuppressive drugs. Because vegetative pyoderma gangrenosum is generally less severe than other forms, it often responds well to treatment. Early diagnosis is important to prevent the wounds from getting larger or becoming infected.
Also known as:
Key symptoms:
A single painful skin sore or ulcer, usually on the trunkWarty or bumpy surface on the woundRaised, well-defined border around the soreSlow growth of the wound over timeRedness and swelling around the affected areaPossible mild discharge or crusting from the woundSkin that is sensitive or tender to touch near the soreSores that may worsen after minor skin injury or trauma
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for Vegetative pyoderma gangrenosum.
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Specialists
View all specialists →No specialists are currently listed for Vegetative pyoderma gangrenosum.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Vegetative pyoderma gangrenosum.
Community
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Caregiver Resources
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Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What tests do I need to confirm this diagnosis and rule out other causes?,Should I be tested for underlying conditions like inflammatory bowel disease or blood disorders?,What treatment do you recommend for my case, and how long will I need to take it?,What are the side effects of the medicines you are prescribing, and how will we monitor for them?,How do I care for my wound at home, and when should I seek urgent medical attention?,What are the chances that this condition will come back, and how can I reduce that risk?,Are there any activities or things I should avoid to prevent new sores from forming?
Common questions about Vegetative pyoderma gangrenosum
What is Vegetative pyoderma gangrenosum?
Vegetative pyoderma gangrenosum is a rare and unusual form of pyoderma gangrenosum, a skin condition that causes painful sores (ulcers) to develop on the skin. Unlike the more common forms of pyoderma gangrenosum, the vegetative type tends to be milder and more localized. It usually appears as a single, slowly growing wound that has a warty or bumpy surface with a raised border. The sores most often show up on the trunk (the chest, belly, or back) and tend not to spread as aggressively as other types. This condition belongs to a group of skin disorders called neutrophilic dermatoses, meaning
How is Vegetative pyoderma gangrenosum inherited?
Vegetative pyoderma gangrenosum follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Vegetative pyoderma gangrenosum typically begin?
Typical onset of Vegetative pyoderma gangrenosum is adult. Age of onset can vary across affected individuals.