Trench fever

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Overview

Trench fever is an infectious disease caused by a bacterium called Bartonella quintana. It gets its name from World War I, when it spread widely among soldiers living in trenches. The disease is also sometimes called five-day fever, quintan fever, or Wolhynia fever. It is spread to humans through the feces of body lice — not through a louse bite itself, but when louse droppings get rubbed into a skin wound or the eyes. The disease mainly affects the blood and causes recurring episodes of fever, severe headache, bone pain (especially in the shins), and a skin rash. Symptoms tend to come and go in cycles, often every five days, which is how it earned the nickname 'five-day fever.' Most people feel very unwell during flare-ups but can recover fully with the right antibiotic treatment. Today, trench fever is most commonly seen in people experiencing homelessness, those living in crowded or unsanitary conditions, and people in areas affected by conflict or disaster. With proper antibiotic treatment, most people recover well. However, in people with weakened immune systems — such as those living with HIV — the infection can become more serious and harder to treat.

Also known as:

Key symptoms:

Recurring fever, often spiking every 5 daysSevere headacheBone pain, especially in the shins (called shin bone pain or tibial pain)Muscle aches and general body painSkin rash (flat red spots, usually on the trunk)Extreme tiredness and weaknessDizzinessEye pain or sensitivity to lightEnlarged spleenNauseaLoss of appetite

Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

Treatments

1 available

Epogen

Epoetin alfa· Amgen, Inc.■ Boxed Warning

Treatment of anemia due to zidovudine in patients with Human Immunodeficiency Virus (HIV) infection

No actively recruiting trials found for Trench fever at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Trench fever community →

No specialists are currently listed for Trench fever.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Trench fever.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Trench fever

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Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What antibiotic will I be taking, and how long do I need to take it?,How do I know if the treatment is working?,What should I do if my fever comes back after I finish antibiotics?,Do the people I live with need to be tested or treated too?,How do I get rid of body lice to prevent getting sick again?,Are there any signs of complications I should watch for at home?,If I have HIV or another immune condition, does my treatment plan change?

Common questions about Trench fever

What is Trench fever?

Trench fever is an infectious disease caused by a bacterium called Bartonella quintana. It gets its name from World War I, when it spread widely among soldiers living in trenches. The disease is also sometimes called five-day fever, quintan fever, or Wolhynia fever. It is spread to humans through the feces of body lice — not through a louse bite itself, but when louse droppings get rubbed into a skin wound or the eyes. The disease mainly affects the blood and causes recurring episodes of fever, severe headache, bone pain (especially in the shins), and a skin rash. Symptoms tend to come and go

How is Trench fever inherited?

Trench fever follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.