Overview
Trench fever is an infectious disease caused by a bacterium called Bartonella quintana. It gets its name from World War I, when it spread widely among soldiers living in trenches. The disease is also sometimes called five-day fever, quintan fever, or Wolhynia fever. It is spread to humans through the feces of body lice — not through a louse bite itself, but when louse droppings get rubbed into a skin wound or the eyes. The disease mainly affects the blood and causes recurring episodes of fever, severe headache, bone pain (especially in the shins), and a skin rash. Symptoms tend to come and go in cycles, often every five days, which is how it earned the nickname 'five-day fever.' Most people feel very unwell during flare-ups but can recover fully with the right antibiotic treatment. Today, trench fever is most commonly seen in people experiencing homelessness, those living in crowded or unsanitary conditions, and people in areas affected by conflict or disaster. With proper antibiotic treatment, most people recover well. However, in people with weakened immune systems — such as those living with HIV — the infection can become more serious and harder to treat.
Also known as:
Key symptoms:
Recurring fever, often spiking every 5 daysSevere headacheBone pain, especially in the shins (called shin bone pain or tibial pain)Muscle aches and general body painSkin rash (flat red spots, usually on the trunk)Extreme tiredness and weaknessDizzinessEye pain or sensitivity to lightEnlarged spleenNauseaLoss of appetite
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
Treatments
1 availableEpogen
Treatment of anemia due to zidovudine in patients with Human Immunodeficiency Virus (HIV) infection
Clinical Trials
View all trials with filters →No actively recruiting trials found for Trench fever at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for Trench fever.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Trench fever.
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What antibiotic will I be taking, and how long do I need to take it?,How do I know if the treatment is working?,What should I do if my fever comes back after I finish antibiotics?,Do the people I live with need to be tested or treated too?,How do I get rid of body lice to prevent getting sick again?,Are there any signs of complications I should watch for at home?,If I have HIV or another immune condition, does my treatment plan change?
Common questions about Trench fever
What is Trench fever?
Trench fever is an infectious disease caused by a bacterium called Bartonella quintana. It gets its name from World War I, when it spread widely among soldiers living in trenches. The disease is also sometimes called five-day fever, quintan fever, or Wolhynia fever. It is spread to humans through the feces of body lice — not through a louse bite itself, but when louse droppings get rubbed into a skin wound or the eyes. The disease mainly affects the blood and causes recurring episodes of fever, severe headache, bone pain (especially in the shins), and a skin rash. Symptoms tend to come and go
How is Trench fever inherited?
Trench fever follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.