Overview
Transient predisposition to invasive pyogenic bacterial infection is a rare immune condition where a person's immune system temporarily struggles to fight off certain types of bacteria — specifically bacteria that have a protective outer coating called a polysaccharide capsule. These bacteria, such as Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis, can cause serious infections like meningitis, pneumonia, and bloodstream infections. The word 'pyogenic' means infections that produce pus, and 'invasive' means the bacteria get into normally sterile parts of the body like the blood or spinal fluid. What makes this condition unique is that the immune weakness is temporary — it tends to occur during a specific window of time, most often in early childhood, and then resolves on its own as the immune system matures. During this vulnerable period, children may experience repeated or unusually severe bacterial infections that would not normally be expected in a healthy child. Management focuses on protecting the person during this vulnerable window. This usually includes preventive antibiotics (called prophylaxis), vaccinations against the most dangerous encapsulated bacteria, and prompt treatment of any infections that do occur. With careful monitoring and preventive care, most affected individuals pass through this period safely and go on to have a normal immune function and life expectancy.
Key symptoms:
Repeated serious bacterial infections such as pneumonia or meningitisBloodstream infections (sepsis) caused by encapsulated bacteriaEar infections that keep coming back or are unusually severeSinus infections that are frequent or hard to treatFever with no clear cause that turns out to be a bacterial infectionUnusually severe response to common bacterial illnessesInfections caused by bacteria normally controlled easily by a healthy immune system
Clinical phenotype terms (7)— hover any for plain English
Variable
Can be inherited in different ways depending on the underlying gene
Infantile
Begins in infancy, roughly 1 month to 2 years old
FDA & Trial Timeline
2 eventsRezzayo: FDA approved
in patients 18 years of age or older who have limited or no alternative options for the treatment of candidemia and invasive candidiasis
Abelcet: FDA approved
Treatment of invasive fungal infections in patients who are refractory to or intolerant of conventional amphotericin B therapy.
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
1 availableAbelcet
Treatment of invasive fungal infections in patients who are refractory to or intolerant of conventional amphotericin B therapy.
Clinical Trials
View all trials with filters →No actively recruiting trials found for Transient predisposition to invasive pyogenic bacterial infection at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for Transient predisposition to invasive pyogenic bacterial infection.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Financial Resources
1 resourcesREZZAYO
Melinta
Candidal Sepsis
Travel Grants
No travel grants are currently matched to Transient predisposition to invasive pyogenic bacterial infection.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How long is my child likely to remain at higher risk for these infections?,Which vaccines does my child need, and on what schedule?,Should my child take daily preventive antibiotics, and for how long?,What are the warning signs that mean I should go to the emergency room right away?,Should my child have genetic testing, and what might it tell us?,Are there any activities or environments my child should avoid during this period?,How will we know when my child's immune system has recovered and extra precautions are no longer needed?
Common questions about Transient predisposition to invasive pyogenic bacterial infection
What is Transient predisposition to invasive pyogenic bacterial infection?
Transient predisposition to invasive pyogenic bacterial infection is a rare immune condition where a person's immune system temporarily struggles to fight off certain types of bacteria — specifically bacteria that have a protective outer coating called a polysaccharide capsule. These bacteria, such as Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis, can cause serious infections like meningitis, pneumonia, and bloodstream infections. The word 'pyogenic' means infections that produce pus, and 'invasive' means the bacteria get into normally sterile parts of the body l
At what age does Transient predisposition to invasive pyogenic bacterial infection typically begin?
Typical onset of Transient predisposition to invasive pyogenic bacterial infection is infantile. Age of onset can vary across affected individuals.
What treatment and support options exist for Transient predisposition to invasive pyogenic bacterial infection?
2 patient support programs are currently tracked on UniteRare for Transient predisposition to invasive pyogenic bacterial infection. See the treatments and support programs sections for copay assistance, eligibility, and contact details.