Overview
Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome is an extremely rare genetic condition that affects the development of the hands and feet. The name describes the main features of this condition: syndactyly means that some fingers or toes are fused or webbed together; camptodactyly refers to a permanent bending of one or more finger joints so the fingers cannot fully straighten; clinodactyly of the fifth fingers means the little fingers curve inward toward the ring finger; and bifid toes means that one or more toes are split or duplicated at the tip. These features are present from birth and result from differences in how the hands and feet form during early development in the womb. This syndrome falls under the broader category of congenital limb malformation syndromes. Because it is so rare, there is limited published medical literature about it. The condition primarily affects the structure and function of the hands and feet, and the severity can vary from person to person. Some individuals may have mild differences that cause little functional limitation, while others may experience more significant challenges with hand grip, fine motor skills, or walking comfort. Treatment is generally focused on improving function and appearance through surgical correction when needed, along with occupational and physical therapy. There is no cure that addresses the underlying genetic cause, but supportive care can significantly improve quality of life.
Also known as:
Key symptoms:
Webbed or fused fingers (syndactyly)Permanently bent finger joints that cannot fully straighten (camptodactyly)Inward curving of the little fingers (clinodactyly)Split or duplicated toes (bifid toes)Difficulty gripping objectsReduced range of motion in the fingersUnusual appearance of hands and feetPossible difficulty with fine motor tasks like writing or buttoning clothesPossible discomfort or difficulty fitting shoes due to toe differences
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome.
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Specialists
View all specialists →No specialists are currently listed for Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How severe are my child's hand and foot differences, and what is the recommended treatment plan?,Will my child need surgery, and if so, at what age is it best to operate?,What results can we expect from surgery in terms of hand function and appearance?,Should we pursue genetic testing, and what would the results mean for our family?,What therapies (occupational or physical) would benefit my child the most?,Are there any risks that this condition could affect other parts of the body?,What accommodations might my child need at school or in daily activities?
Common questions about Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome
What is Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome?
Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome is an extremely rare genetic condition that affects the development of the hands and feet. The name describes the main features of this condition: syndactyly means that some fingers or toes are fused or webbed together; camptodactyly refers to a permanent bending of one or more finger joints so the fingers cannot fully straighten; clinodactyly of the fifth fingers means the little fingers curve inward toward the ring finger; and bifid toes means that one or more toes are split or duplicated at the tip. These feature
How is Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome inherited?
Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome typically begin?
Typical onset of Syndactyly-camptodactyly and clinodactyly of fifth fingers-bifid toes syndrome is neonatal. Age of onset can vary across affected individuals.