Clinical trials for Squamous cell carcinoma of head and neck
100 recruiting or active trials synced from ClinicalTrials.gov.
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Clinical trial records are synced from ClinicalTrials.gov through automated extraction.
Report missing data- RECRUITINGPhase 3NCT07333274Compare Radiotherapy Plus Nimotuzumab Versus Radiotherapy Alone in Platinum-ineligible Patients With Locoregionally Advanced Head and Neck Squamous Cell CarcinomaShandong Cancer Hospital and Institute · PI: Man Hu
- RECRUITINGPhase 1NCT07182149A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid TumorsNormunity AccelCo, Inc. · PI: Viviana Bozon, MD
- RECRUITINGPhase 3NCT07026474Re-Radiochemotherapy and Pembrolizumab vs. Immuno(Chemo)Therapy for Locoregionally Recurrent PD-L1 Positive (CPS≥1) HNSCCUniversität des Saarlandes
- RECRUITINGN/ANCT07203911Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled TrialTobias Todsen
- RECRUITINGN/ANCT07180901Proactive Risk-based Optimization & Notifications for Treatment & Outcomes in Head & Neck CancerCentre hospitalier de l'Université de Montréal (CHUM) · PI: Houda Bahig, MD PhD
- ACTIVE NOT RECRUITINGEarly Phase 1NCT07435415Local Injection Methylene Blue Combined With Radiation in HNSCC PatientsChina Medical University Hospital
- RECRUITINGPhase 2NCT07088211Sacituzumab Tirumotecan and Toripalimab in the First-line Treatment of HNSCCShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · PI: Yue He, M.D.
- RECRUITINGPhase 2NCT07040956A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients.West China Hospital
- RECRUITINGPhase 2NCT06856213Study of Cetuximab Plus/Minus Weekly Paclitaxel After Progression To First-Line Pembrolizumab Plus Platinum-5FU in Subjects With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck.Grupo Español de Tratamiento de Tumores de Cabeza y Cuello · PI: Santiago Cabezas, M.D., Ph.D.
- RECRUITINGPHASE1, PHASE2NCT07010120A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell CarcinomaWest China Hospital · PI: Xingchen Peng
- RECRUITINGPhase 3NCT05815927Pembrolizumab and Radiotherapy for Oligometastatic Head and Neck CancerEuropean Organisation for Research and Treatment of Cancer - EORTC · PI: Panagiotis Belermpas, MD
- RECRUITINGEarly Phase 1NCT06819228Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck CancerVanderbilt-Ingram Cancer Center · PI: Eben L Rosenthal, MD
- RECRUITINGN/ANCT05774483Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe NegativeTata Memorial Hospital · PI: Richa Vaish, MS, M.Ch
- RECRUITINGEarly Phase 1NCT06700070A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid TumorsPure Biologics S.A. · PI: John Weinberg, MBBCH
- RECRUITINGPhase 2NCT06563362Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell CarcinomaUniversity of Zurich · PI: Panagiotis Balermpas, MD
- RECRUITINGNCT06174428Validity of Viome's Oral/throat Cancer TestViome · PI: Cristina Julian
- RECRUITINGN/ANCT06607406Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Than 6 Weeks After SurgeryWake Forest University Health Sciences · PI: Ryan Hughes, MD
- RECRUITINGPhase 2NCT06752798Bone Marrow Protective Effect of Trilaciclib in Postoperative CCRT for LA-HNSCCHunan Cancer Hospital
- RECRUITINGPhase 1NCT06540443Pilot Study of MPB-2043 Enhanced MRI for Nodal Staging in Head and Neck Squamous Cell CarcinomasMegaPro Biomedical Co. Ltd. · PI: Pei-Jen Lou, MD., PhD
- ACTIVE NOT RECRUITINGPhase 2NCT07267286Tirellizumab Combined With TP Neoadjuvant Therapy in the Treatment of Early Oral Squamous Cell Carcinoma (HNC-SYSU-005)Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- RECRUITINGNCT07448727Impact of Early Response to First-line Anti-PD-1 Monotherapy in Patients With Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma, Assessed by 18F-FDG PET/CTUniversity of Rome Tor Vergata
- RECRUITINGEarly Phase 1NCT06579248Intraoral Hypothermia Device for Preserving Taste During RadiationHenry Ford Health System
- RECRUITINGPhase 2NCT06668961A Study of SI-B001+SI-B003 Combined With Platinum-based Chemotherapy as First-line Treatment in Patients With Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaSichuan Baili Pharmaceutical Co., Ltd.
- RECRUITINGPhase 1NCT06515990A Study of DM005 in Patients With Advanced Solid TumorsDoma Biopharmaceutical(Suzhou)Co., Ltd.
- RECRUITINGPhase 3NCT06601335A Phase 3 Study of AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)Akeso
- RECRUITINGPhase 2NCT06194656Clinical Trial of SIBP-03 in Patients With Head and Neck Squamous Cell CarcinomaShanghai Institute Of Biological Products · PI: Ye Guo, Doctor
- RECRUITINGN/ANCT06623266Neck Observation or Elective Neck Dissection in CT1N0M0 OSCCHuashan Hospital · PI: Lai-ping Zhong, MD, PhD
- RECRUITINGPhase 3NCT064924602 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell CarcinomaSun Yat-sen University · PI: Lei Chen, M.D
- RECRUITINGPhase 1NCT06444815A Study of VET3-TGI in Patients With Solid TumorsKaliVir Immunotherapeutics
- RECRUITINGPhase 2NCT06611137SBRT Followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Larynx Preservation in Patients with Locally Regionally Advanced Squamous Cell Carcinoma of the Larynx and HypopharynxSun Yat-sen University
- RECRUITINGNCT06575322Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Pain, Anxiety and Depression in Patients With Resectable Head and Neck Squamous Cell CarcinomaSun Yat-Sen Memorial Hospital of Sun Yat-Sen University · PI: Song Fan, Doctor
- ACTIVE NOT RECRUITINGPhase 3NCT07435324A Comparative Study of Efficacy and Safety of RPH-002 and Erbitux® in Unresectable Metastatic or Recurrent Head and Neck Squamous Cell CarcinomaR-Pharm · PI: Mikhail Samsonov
- RECRUITINGNCT06755762Using a 3D Culture Model for Circulating Tumor Cells Combined With Molecular Bioassays in Patients With HNSCC CancerChang Gung Memorial Hospital · PI: Chia-Hsun Hsieh, PhD
- RECRUITINGPHASE1, PHASE2NCT06380816A Phase I/II Trial of UCB4594 in Participants With Advanced CancerCancer Research UK · PI: Fiona Thistlethwaite, Prof
- RECRUITINGPhase 2NCT06444009A Phase II Study of Neoadjuvant Immunotherapy in Combination With Chemotherapy in Locally Advanced Head and Neck Squamous Cell CarcinomaLei Liu
- RECRUITINGPhase 1NCT06469008A Study of BL-B16D1 in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid TumorsSichuan Baili Pharmaceutical Co., Ltd. · PI: Ye Guo
- RECRUITINGPhase 2NCT06437522A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid TumorsSichuan Baili Pharmaceutical Co., Ltd. · PI: Chaosu Hu
- ACTIVE NOT RECRUITINGPHASE2, PHASE3NCT06295731INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCCInhibrx Biosciences, Inc · PI: Clinical Lead
- ACTIVE NOT RECRUITINGPhase 1NCT05973487A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid TumorsTScan Therapeutics, Inc. · PI: Dawn Pinchasik, MD
- RECRUITINGPhase 2NCT06137378European Larynx Organ Preservation Study (ELOS) [MK-3475-C44]University of Leipzig
- RECRUITINGPhase 2NCT06323369Tislelizumab Combined With Chemotherapy Followed by Surgery Versus Up-front Surgery in Resectable Clinically Node-negative Head and Neck Squamous Cell CarcinomaSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- RECRUITINGPhase 1NCT06242470A Study of MGC026 in Participants With Advanced Solid TumorsMacroGenics · PI: Denise Casey, MD
- RECRUITINGPhase 2NCT05913388GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell CarcinomaProvidence Health & Services · PI: Brendan D. Curti, MD
- RECRUITINGPhase 4NCT06162377Methylnatrexone In Resectable Head and Neck Squamous Cell Carcinoma (MINK). A "Window of Opportunity" Pilot Study.M.D. Anderson Cancer Center · PI: Juan Cata, MD
- RECRUITINGPhase 2NCT06345287Response Adaptive Radiotherapy Following Immunotherapy-based Induction for Non-HPV Related HNSCCCancer Institute and Hospital, Chinese Academy of Medical Sciences · PI: Junlin Yi, Doctor
- RECRUITINGPHASE1, PHASE2NCT06016920Safety and Efficacy of VB10.16 and Pembrolizumab in Patients with Head-Neck Squamous Cell CarcinomaNykode Therapeutics ASA · PI: Åse Bratland, MD, PhD
- ACTIVE NOT RECRUITINGPhase 2NCT06137274Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCCH. Lee Moffitt Cancer Center and Research Institute · PI: George Yang, MD
- RECRUITINGN/ANCT06183268Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton TherapyCovenant Health Cancer Center · PI: Samantha Hedrick, PhD, DABR
- RECRUITINGN/ANCT05733910Simultaneous Integrated Boost in Carbon Ion Radiotherapy for Head and Neck Adenoid Cystic CarcinomaCNAO National Center of Oncological Hadrontherapy · PI: Sara Ronchi, MD
- RECRUITINGEarly Phase 1NCT05553782Drug Screening Using Novel IMD in Salivary and Head and Neck CancersBrigham and Women's Hospital · PI: Glenn J. Hanna, M.D
- RECRUITINGPhase 2NCT06100497Efficacy and Safety of PD-1 Plus Chemotherapy in Poorly Differentiated Locally Advanced (LA) HNSCCBeijing Tongren Hospital
- RECRUITINGPHASE1, PHASE2NCT06022757Study of XNW5004 Tablet in Combination With KEYTRUDA® (Pembrolizumab) in Subjects With Advanced Solid Tumors Who Failed Standard Treatments (KEYNOTE F19)Evopoint Biosciences Inc. · PI: Li Zhang, M.D.
- RECRUITINGNCT05328024Identification of Predictive Factors for the Response to Anti-Programmed Cell Death Protein 1 (PD1) Immunotherapy in Head and Neck Squamous Cell CarcinomaInstitut de cancérologie Strasbourg Europe
- RECRUITINGPHASE1, PHASE2NCT05955105A Study of ILB2109 and Toripalimab in Patients With Advanced Solid MalignanciesInnolake Biopharm · PI: Jin Li, M.D.
- ACTIVE NOT RECRUITINGNCT05812027A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid TumorsTScan Therapeutics, Inc. · PI: Dawn Pinchasik, MD
- ACTIVE NOT RECRUITINGPhase 1NCT05902520Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid TumorsAgonOx, Inc.
- RECRUITINGPhase 2NCT05681039Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).M.D. Anderson Cancer Center · PI: Luana Guimaraes De Sousa, MD PhD
- RECRUITINGPhase 1NCT05526924Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck CancerUniversity of Chicago · PI: Ari Rosenberg, MD
- RECRUITINGPhase 2NCT05941338Tirelizumab in Combination With Carboplatin and Albumin-binding Paclitaxel for Neoadjuvant Therapy in HNSCCSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- RECRUITINGPhase 1NCT05683418A Study to Evaluate the Safety and Tolerability of TOS-358 in Adults With HR+ Breast Cancer and Other Select Solid TumorsTotus Medicines · PI: Zelanna Goldberg, MD
- ACTIVE NOT RECRUITINGPhase 2NCT05724329Neoadjuvant Tislelizumab in Combination With Dasatinib and Quercetin in Resectable HNSCC (COIS-01)Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- RECRUITINGPhase 2NCT05777824Postoperative Management for HNSCC Based on Pathological Response of Induction Chemotherapy and ImmunotherapyCancer Institute and Hospital, Chinese Academy of Medical Sciences · PI: Junlin Yi, Doctor
- ACTIVE NOT RECRUITINGPhase 2NCT05287113Study of Retinfanlimab in Combination With INCAGN02385 and INCAGN02390 as First-Line Treatment in Participants With PD-L1-Positive (CPS ≥ 1) Recurrent/Metastatic Squamous Cell Carcinoma of the Head and NeckIncyte Biosciences International Sàrl
- ACTIVE NOT RECRUITINGPhase 2NCT05608876A Clinical Study to Investigate the Efficacy of Tigilanol Tiglate Directly in Head and Neck CancerQBiotics Group Limited · PI: Richard Gallagher, MBBS
- ACTIVE NOT RECRUITINGN/ANCT05338905Intensive Symptom Surveillance Guided by Machine Learning-Directed Risk Stratification in Patients With Non-Metastatic Head and Neck Cancer, The INSIGHT TrialRoswell Park Cancer Institute · PI: Anurag K Singh
- RECRUITINGN/ANCT05437380Peritumoral Microbubbles and CEUS for SLN Detection and Biopsy in HNSCCSun Yat-Sen Memorial Hospital of Sun Yat-Sen University · PI: Huang Xiaoming, M.D.
- RECRUITINGPhase 2NCT05544136A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck CancerMemorial Sloan Kettering Cancer Center · PI: Zeinab Abou Yehia, MD
- RECRUITINGPhase 2NCT05446467Pembrolizumab in Combination With Low-dose PFas Neoadjuvant Treatment for Locally Advanced HNSCCZhejiang Provincial People's Hospital · PI: Minghua Ge, PhD
- RECRUITINGNCT05539638The Role of Circulating Tumour DNA in Head and Neck CancerUniversity of Edinburgh · PI: Ashley Tay
- RECRUITINGPhase 2NCT04191460Fluorescence-guided Surgery Using cRGD-ZW800-1 in Oral CancerErasmus Medical Center
- ACTIVE NOT RECRUITINGPhase 2NCT05286294Microbiota Transplant to Cancer Patients Who Have Failed Immunotherapy Using Faeces From Clinical RespondersOslo University Hospital · PI: Jon Amund Kyte, MD, Ph.D.
- RECRUITINGNCT05483374The Head and Neck Registry of the European Reference Network on Rare Adult Solid CancersFondazione IRCCS Istituto Nazionale dei Tumori, Milano · PI: Annalisa Trama, MD
- RECRUITINGPhase 2NCT05280457HPV 16-positive and/or HPV 18-positive Recurrent and/or For Patients With Metastatic Head and Neck Cancer to Evaluate GX-188E DNA Vaccination, GX-I7 and Nivolumab Combination TherapyYonsei University
- ACTIVE NOT RECRUITINGPhase 1NCT05249426A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver CancerBoehringer Ingelheim
- RECRUITINGPhase 2NCT05343325The Efficacy and Safety of Neoadjuvant Low-dose Radiotherapy Combined With Chemoimmunotherapy in Locally Advanced HNSCCFifth Affiliated Hospital, Sun Yat-Sen University
- ACTIVE NOT RECRUITINGPhase 2NCT05077709IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBCIO Biotech · PI: Jonathan W Riess, MD, MSc
- ACTIVE NOT RECRUITINGPhase 2NCT05145907Study to Evaluate Safety and Efficacy of TJ107 Combine With PD-1 in Patients With Solid TumorsTJ Biopharma Co., Ltd. · PI: Liyang Song, Master
- ACTIVE NOT RECRUITINGPhase 2NCT05054439A Clinical Study of SI-B001 in Combination With Paclitaxel in the Treatment of Recurrent and Metastatic HNSCCSichuan Baili Pharmaceutical Co., Ltd.
- RECRUITINGNCT05192655Artificial Intelligence in Functional Imaging for Individualized Treatment of Head and Neck Squamous Cell Carcinoma PatientsCharite University, Berlin, Germany
- ACTIVE NOT RECRUITINGPhase 2NCT04831320Nab-Paclitaxel in Combination With Nivolumab to Treat Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma That Progressed on a PD-1 or PD-L1 InhibitorWashington University School of Medicine · PI: Douglas R Adkins, M.D.
- RECRUITINGNCT05030597Exploring the Application Value of PET Molecular Imaging Targeting FAP in Oral Squamous Cell CarcinomaZhongnan Hospital · PI: He Yong, PhD
- ACTIVE NOT RECRUITINGPhase 2NCT04643379Olaparib in Combination With Pembrolizumab and Carboplatin as First-Line Treatment of Recurrent or Metastatic Head and Neck Squamous-Cell CarcinomaWashington University School of Medicine · PI: Douglas Adkins, M.D.
- RECRUITINGPhase 2NCT04992559A Study of Toripalimab as Consolidation Therapy After Postoperative Chemoradiotherapy in HNSCCSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- ACTIVE NOT RECRUITINGPhase 2NCT04651634MIT-001 for Prevention of CCRT-Induced OM in HNSCC PatientsMitoImmune Therapeutics · PI: Jinsang Jung, M.Pharm
- RECRUITINGN/ANCT04688528Dose De-escalation and Sentinel LN Mapping Driven Radiotherapy of Contralateral Neck in Ipsilateral Node Positive HNSCCUniversitaire Ziekenhuizen KU Leuven · PI: Jean-François Daisne, Prof. Dr.
- ACTIVE NOT RECRUITINGPHASE1, PHASE2NCT04843098Study of TL117 in Patients With Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaSuzhou Junde Biotechnology Co., Ltd
- ACTIVE NOT RECRUITINGNCT05987579Surgical Treatment of Stage T3 Squamous Cell Carcinomas of the ScalpMaastricht University Medical Center · PI: Nicole Kelleners-Smeets, dr.
- RECRUITINGPhase 2NCT04857164Study of Pembrolizumab Combined with Chemotherapy in the First Line Therapy for R/M HNSCC in ChinaYuankai Shi · PI: Yuankai Shi, MD
- RECRUITINGNCT04892849Clinical Benefit and Biomarker Analysis of Combination of PD-1/PD-L1 Immune Checkpoint Inhibitors and RadiotherapyUniversity of Erlangen-Nürnberg Medical School · PI: Markus Hecht, PD Dr.
- ACTIVE NOT RECRUITINGPhase 2NCT04848116Neoadjuvant Targeting of Myeloid Cell Populations in Combination With Nivolumab in Head & Neck CaSidney Kimmel Comprehensive Cancer Center at Johns Hopkins · PI: Carole Fakhry, M.D.
- RECRUITINGPhase 2NCT04826679Neoadjuvant Camrelizumab in Combination With Cisplatin and Nab-paclitaxel in Resectable HNSCCSun Yat-sen University · PI: xuekui Liu
- ACTIVE NOT RECRUITINGPhase 2NCT04609280Selective Avoidance of Nodal VolumEs at Minimal Risk (GCC 20110)University of Maryland, Baltimore · PI: Matthew Witek, MD
- RECRUITINGPhase 2NCT04681469Induction and Maintenance Treatment With PARP Inhibitor and Immunotherapy in HPV-negative HNSCCGruppo Oncologico del Nord-Ovest · PI: Paolo Bossi
- RECRUITINGPHASE2, PHASE3NCT04534205A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1BioNTech SE · PI: BioNTech Responsible Person
- RECRUITINGPhase 1NCT03740256Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid TumorsBaylor College of Medicine · PI: Shalini Makawita, MD
- RECRUITINGNCT04567056Specific Methylation Profiles in HNSCCAalborg University Hospital · PI: Michael Gaihede, Professor
- ACTIVE NOT RECRUITINGN/ANCT04603248A Study for Identification of Immune Determinants for Response to Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell CarcinomaYonsei University · PI: Hye Ryun Kim
- ACTIVE NOT RECRUITINGPHASE1, PHASE2NCT04403620HYPORT: A Phase I/II Study of Hypofractionated Post-operative Radiation Therapy for Head and Neck CancerUniversity of Texas Southwestern Medical Center · PI: Dominic Moon, MD
- ACTIVE NOT RECRUITINGPhase 2NCT04369937HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for "Intermediate Risk" HPV-16-associated Head and Neck Squamous Cell CarcinomaDan Zandberg · PI: Dan P Zandberg, MD
- RECRUITINGPhase 1NCT04429542Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid TumorsBicara Therapeutics