Overview
Silent sinus syndrome (SSS), also called imploding antrum syndrome or maxillary sinus atelectasis, is a rare condition where one of the maxillary sinuses — the air-filled spaces behind your cheekbones — slowly collapses inward over time. Unlike most sinus problems, this condition is called 'silent' because it often causes no pain or obvious sinus symptoms at first. Instead, the sinus gradually shrinks and the walls cave in, which can pull the floor of the eye socket downward. This leads to a sunken or drooping appearance of one eye, a condition called enophthalmos, and sometimes double vision. The exact cause is not fully understood, but most experts believe it happens when the natural drainage opening of the sinus becomes blocked, causing a slow buildup of negative pressure inside the sinus. Over months or years, this negative pressure causes the sinus walls to collapse. It is not a genetic disease and is not passed down in families. Treatment usually involves surgery to restore normal airflow to the sinus and, if needed, to rebuild the floor of the eye socket. Most people do very well after surgery, with improvement in eye position and appearance. Early diagnosis is important to prevent permanent changes to the eye socket.
Key symptoms:
Sunken or drooping appearance of one eyeDouble vision (seeing two images at once)Downward displacement of the eyeballFacial asymmetry (one side of the face looks different from the other)Feeling of pressure or fullness in the cheek areaGradual changes in visionFlattening of the cheek on one sideWidening of the space between the eyelids on the affected sideMild or no nasal or sinus symptoms
Clinical phenotype terms (3)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for Silent sinus syndrome.
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Silent sinus syndrome.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How far has my sinus collapsed, and has the floor of my eye socket been affected?,Do I need one surgery or two, and what is the recovery time for each?,Will my eye position and double vision fully return to normal after surgery?,What happens if I choose not to have surgery — will the condition keep getting worse?,Are there any risks specific to my case that I should know about before surgery?,How often will I need follow-up imaging or check-ups after treatment?,Is there any chance this condition could come back after surgery?
Common questions about Silent sinus syndrome
What is Silent sinus syndrome?
Silent sinus syndrome (SSS), also called imploding antrum syndrome or maxillary sinus atelectasis, is a rare condition where one of the maxillary sinuses — the air-filled spaces behind your cheekbones — slowly collapses inward over time. Unlike most sinus problems, this condition is called 'silent' because it often causes no pain or obvious sinus symptoms at first. Instead, the sinus gradually shrinks and the walls cave in, which can pull the floor of the eye socket downward. This leads to a sunken or drooping appearance of one eye, a condition called enophthalmos, and sometimes double vision.
How is Silent sinus syndrome inherited?
Silent sinus syndrome follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Silent sinus syndrome typically begin?
Typical onset of Silent sinus syndrome is adult. Age of onset can vary across affected individuals.
Which specialists treat Silent sinus syndrome?
15 specialists and care centers treating Silent sinus syndrome are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.