Silent sinus syndrome

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15Specialists8Treatment centers

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Overview

Silent sinus syndrome (SSS), also called imploding antrum syndrome or maxillary sinus atelectasis, is a rare condition where one of the maxillary sinuses — the air-filled spaces behind your cheekbones — slowly collapses inward over time. Unlike most sinus problems, this condition is called 'silent' because it often causes no pain or obvious sinus symptoms at first. Instead, the sinus gradually shrinks and the walls cave in, which can pull the floor of the eye socket downward. This leads to a sunken or drooping appearance of one eye, a condition called enophthalmos, and sometimes double vision. The exact cause is not fully understood, but most experts believe it happens when the natural drainage opening of the sinus becomes blocked, causing a slow buildup of negative pressure inside the sinus. Over months or years, this negative pressure causes the sinus walls to collapse. It is not a genetic disease and is not passed down in families. Treatment usually involves surgery to restore normal airflow to the sinus and, if needed, to rebuild the floor of the eye socket. Most people do very well after surgery, with improvement in eye position and appearance. Early diagnosis is important to prevent permanent changes to the eye socket.

Also known as:

Key symptoms:

Sunken or drooping appearance of one eyeDouble vision (seeing two images at once)Downward displacement of the eyeballFacial asymmetry (one side of the face looks different from the other)Feeling of pressure or fullness in the cheek areaGradual changes in visionFlattening of the cheek on one sideWidening of the space between the eyelids on the affected sideMild or no nasal or sinus symptoms

Clinical phenotype terms (3)— hover any for plain English
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Adult

Begins in adulthood (age 18 or older)

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Silent sinus syndrome.

View clinical trials →

No actively recruiting trials found for Silent sinus syndrome at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Silent sinus syndrome community →

Specialists

15 foundView all specialists →
KG
Karolina Goroszkiewicz
Specialist
2 Silent sinus syndrome publications
MM
Maciej Misiołek
Specialist
2 Silent sinus syndrome publications
GF
Giovanni Felisati
Specialist
2 Silent sinus syndrome publications
CP
Carlotta Pipolo
Specialist
2 Silent sinus syndrome publications
GS
Grażyna Stryjewska-Makuch
Specialist
2 Silent sinus syndrome publications
CR
Cecilia Rosso
Specialist
1 Silent sinus syndrome publication
AD
A T Du
Specialist
1 Silent sinus syndrome publication
SS
Samaneh Salari
Specialist
1 Silent sinus syndrome publication
NA
Najme Anbiaee
Specialist
1 Silent sinus syndrome publication
AA
A Abiri
PITTSBURGH, PA
Specialist
1 Silent sinus syndrome publication
LM
L Michelle
SPARKS, NV
Specialist
1 Silent sinus syndrome publication
EK
E C Kuan
Specialist
1 Silent sinus syndrome publication
AS
Alberto Maria Saibene
Specialist
2 Silent sinus syndrome publications
BG
Ben Gvili
Specialist
1 Silent sinus syndrome publication
AY
Arkadi Yakirevitch
Specialist
1 Silent sinus syndrome publication

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Silent sinus syndrome.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Silent sinus syndrome

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Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

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Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.How far has my sinus collapsed, and has the floor of my eye socket been affected?,Do I need one surgery or two, and what is the recovery time for each?,Will my eye position and double vision fully return to normal after surgery?,What happens if I choose not to have surgery — will the condition keep getting worse?,Are there any risks specific to my case that I should know about before surgery?,How often will I need follow-up imaging or check-ups after treatment?,Is there any chance this condition could come back after surgery?

Common questions about Silent sinus syndrome

What is Silent sinus syndrome?

Silent sinus syndrome (SSS), also called imploding antrum syndrome or maxillary sinus atelectasis, is a rare condition where one of the maxillary sinuses — the air-filled spaces behind your cheekbones — slowly collapses inward over time. Unlike most sinus problems, this condition is called 'silent' because it often causes no pain or obvious sinus symptoms at first. Instead, the sinus gradually shrinks and the walls cave in, which can pull the floor of the eye socket downward. This leads to a sunken or drooping appearance of one eye, a condition called enophthalmos, and sometimes double vision.

How is Silent sinus syndrome inherited?

Silent sinus syndrome follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Silent sinus syndrome typically begin?

Typical onset of Silent sinus syndrome is adult. Age of onset can vary across affected individuals.

Which specialists treat Silent sinus syndrome?

15 specialists and care centers treating Silent sinus syndrome are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.