Overview
Ringed hair disease, also known as pili annulati, is a rare inherited condition that affects the structure of hair. The name comes from the distinctive appearance of the hair shafts, which show alternating light and dark bands when viewed under a microscope or in bright light. These bands give the hair a 'ringed' or striped look. The light bands are caused by tiny air-filled cavities inside the hair shaft, which scatter light differently than the solid, darker sections. Most people with pili annulati have hair that looks shiny or sparkling in sunlight, which is often the first thing noticed. The hair itself is usually not fragile or prone to breaking, which sets this condition apart from many other hair shaft disorders. In most cases, the scalp hair is affected, though body hair can sometimes show similar changes. There is no cure for ringed hair disease, and treatment is generally not needed because the condition does not cause serious health problems. Management focuses on gentle hair care to avoid unnecessary damage. The condition is considered cosmetic in nature, and most people with pili annulati live completely normal, healthy lives.
Also known as:
Key symptoms:
Alternating light and dark bands on hair shafts giving a ringed or striped appearanceHair that appears to sparkle or glitter in bright or direct sunlightShiny appearance of scalp hairHair that is generally not brittle or fragileCosmetic changes to hair color and textureOccasional mild increased hair fragility in some individualsChanges visible mainly on scalp hair, sometimes on eyebrows or body hair
Clinical phenotype terms (2)— hover any for plain English
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Childhood
Begins in childhood, roughly ages 1 to 12
Treatments
No FDA-approved treatments are currently listed for Ringed hair disease.
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Specialists
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Ringed hair disease.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is my diagnosis confirmed as pili annulati, and how was it identified?,Should I have genetic testing, and what would it tell me?,Are there any hair care products or routines I should avoid?,Could my children inherit this condition, and should they be checked?,Are there any other health conditions associated with pili annulati that I should watch for?,Do I need any follow-up appointments, or is this a one-time diagnosis?,Are there any support groups or resources for people with rare hair conditions?
Common questions about Ringed hair disease
What is Ringed hair disease?
Ringed hair disease, also known as pili annulati, is a rare inherited condition that affects the structure of hair. The name comes from the distinctive appearance of the hair shafts, which show alternating light and dark bands when viewed under a microscope or in bright light. These bands give the hair a 'ringed' or striped look. The light bands are caused by tiny air-filled cavities inside the hair shaft, which scatter light differently than the solid, darker sections. Most people with pili annulati have hair that looks shiny or sparkling in sunlight, which is often the first thing noticed.
How is Ringed hair disease inherited?
Ringed hair disease follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Ringed hair disease typically begin?
Typical onset of Ringed hair disease is childhood. Age of onset can vary across affected individuals.