Ringed hair disease

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ORPHA:169OMIM:180600Q84.1
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Overview

Ringed hair disease, also known as pili annulati, is a rare inherited condition that affects the structure of hair. The name comes from the distinctive appearance of the hair shafts, which show alternating light and dark bands when viewed under a microscope or in bright light. These bands give the hair a 'ringed' or striped look. The light bands are caused by tiny air-filled cavities inside the hair shaft, which scatter light differently than the solid, darker sections. Most people with pili annulati have hair that looks shiny or sparkling in sunlight, which is often the first thing noticed. The hair itself is usually not fragile or prone to breaking, which sets this condition apart from many other hair shaft disorders. In most cases, the scalp hair is affected, though body hair can sometimes show similar changes. There is no cure for ringed hair disease, and treatment is generally not needed because the condition does not cause serious health problems. Management focuses on gentle hair care to avoid unnecessary damage. The condition is considered cosmetic in nature, and most people with pili annulati live completely normal, healthy lives.

Also known as:

Key symptoms:

Alternating light and dark bands on hair shafts giving a ringed or striped appearanceHair that appears to sparkle or glitter in bright or direct sunlightShiny appearance of scalp hairHair that is generally not brittle or fragileCosmetic changes to hair color and textureOccasional mild increased hair fragility in some individualsChanges visible mainly on scalp hair, sometimes on eyebrows or body hair

Clinical phenotype terms (2)— hover any for plain English
Abnormal hair patternHP:0010720
Inheritance

Autosomal dominant

Passed on from just one parent; each child has about a 50% chance of inheriting it

Age of Onset

Childhood

Begins in childhood, roughly ages 1 to 12

Orphanet ↗OMIM ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Ringed hair disease.

View clinical trials →

No actively recruiting trials found for Ringed hair disease at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Ringed hair disease community →

No specialists are currently listed for Ringed hair disease.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Ringed hair disease.

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Community

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Latest news about Ringed hair disease

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Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.Is my diagnosis confirmed as pili annulati, and how was it identified?,Should I have genetic testing, and what would it tell me?,Are there any hair care products or routines I should avoid?,Could my children inherit this condition, and should they be checked?,Are there any other health conditions associated with pili annulati that I should watch for?,Do I need any follow-up appointments, or is this a one-time diagnosis?,Are there any support groups or resources for people with rare hair conditions?

Common questions about Ringed hair disease

What is Ringed hair disease?

Ringed hair disease, also known as pili annulati, is a rare inherited condition that affects the structure of hair. The name comes from the distinctive appearance of the hair shafts, which show alternating light and dark bands when viewed under a microscope or in bright light. These bands give the hair a 'ringed' or striped look. The light bands are caused by tiny air-filled cavities inside the hair shaft, which scatter light differently than the solid, darker sections. Most people with pili annulati have hair that looks shiny or sparkling in sunlight, which is often the first thing noticed.

How is Ringed hair disease inherited?

Ringed hair disease follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Ringed hair disease typically begin?

Typical onset of Ringed hair disease is childhood. Age of onset can vary across affected individuals.