Reye syndrome

Reye syndrome (also called Reye's syndrome) is a rare but serious condition that causes swelling in the liver and brain. It most often affects children and teenagers who are recovering from a viral infection, such as the flu or chickenpox, especially if they have taken aspirin during the illness. The exact cause is not fully understood, but the strong link between aspirin use in children during viral illnesses and the development of Reye syndrome has been well established. The condition typically begins with severe, persistent vomiting, followed by unusual sleepiness, confusion, and behavioral changes. As the disease progresses, it can lead to seizures, loss of consciousness, and coma. The liver becomes swollen and fatty, and ammonia and other toxins build up in the blood because the liver cannot process them properly. Brain swelling (cerebral edema) is the most dangerous complication and can be life-threatening. Since the 1980s, when public health warnings about aspirin use in children were widely issued, the number of Reye syndrome cases has dropped dramatically. Treatment focuses on reducing brain swelling, correcting metabolic problems, and supporting liver function in an intensive care setting. There is no specific cure, so early recognition and aggressive supportive care are critical to improving outcomes. With prompt treatment, many children recover, though some may have lasting neurological effects.

Bring these to your next appointment

• Q1.How severe is my child's case, and what stage of Reye syndrome are they in?,What is the expected timeline for recovery, and what should we watch for during recovery?,Should my child be tested for underlying metabolic disorders that can look like Reye syndrome?,What long-term neurological effects should we watch for after discharge?,Will my child need rehabilitation services such as physical therapy, speech therapy, or special education support?,Are there any medications or over-the-counter products we should avoid in the future?,Is there any risk that this could happen again, or are siblings at risk?

Common questions about Reye syndrome