Overview
Orphanet code 506213 refers to a rare kidney disorder that may require a kidney transplant as part of its treatment. This category covers a group of serious inherited or acquired kidney diseases where the kidneys gradually lose their ability to filter waste and fluids from the blood. Over time, this can lead to chronic kidney disease (CKD) and eventually kidney failure, also called end-stage renal disease (ESRD). When the kidneys can no longer do their job, a transplant may become the best long-term option. These conditions can affect people of all ages, though many begin in childhood or early adulthood. Symptoms often develop slowly and may include swelling in the legs and ankles, high blood pressure, fatigue, and changes in how much urine the body produces. Because this Orphanet code is a broad grouping rather than a single named disease, the exact symptoms, causes, and genetic factors depend on the specific underlying condition a person has been diagnosed with. Treatment focuses on slowing kidney damage, managing symptoms, and preparing for kidney replacement therapy when needed. Kidney transplant offers the best quality of life for many patients with end-stage kidney failure. Dialysis is another option to replace kidney function temporarily. A team of specialists works together to find the best plan for each person.
Key symptoms:
Swelling in the legs, ankles, or feetHigh blood pressure that is hard to controlFeeling very tired or weakProducing less urine than normal, or changes in urine colorFoamy or bubbly urine (a sign of protein in the urine)Nausea or loss of appetiteDifficulty concentrating or feeling mentally foggyItchy skinMuscle cramps, especially at nightShortness of breath due to fluid buildup
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
1 eventEnvarsus XR: FDA approved
ENVARSUS XR is indicated for the prophylaxis of organ rejection in kidney transplant patients in combination with other immunosuppressants.
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
1 availableEnvarsus XR
ENVARSUS XR is indicated for the prophylaxis of organ rejection in kidney transplant patients in combination with other immunosuppressants.
Clinical Trials
View all trials with filters →No actively recruiting trials found for Rare disorder potentially indicated for kidney transplant at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for Rare disorder potentially indicated for kidney transplant.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Rare disorder potentially indicated for kidney transplant.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is the specific name of my kidney disease, and what is causing it?,Should I have genetic testing, and could this condition affect other family members?,How quickly might my kidney function decline, and what signs should I watch for?,When should we start talking about transplant, and how do I get on the waiting list?,If I receive a transplant, is there a risk that my disease could come back in the new kidney?,Are there any clinical trials or new treatments I should know about?,What dietary changes should I make right now to protect my kidneys?
Common questions about Rare disorder potentially indicated for kidney transplant
What is Rare disorder potentially indicated for kidney transplant?
Orphanet code 506213 refers to a rare kidney disorder that may require a kidney transplant as part of its treatment. This category covers a group of serious inherited or acquired kidney diseases where the kidneys gradually lose their ability to filter waste and fluids from the blood. Over time, this can lead to chronic kidney disease (CKD) and eventually kidney failure, also called end-stage renal disease (ESRD). When the kidneys can no longer do their job, a transplant may become the best long-term option. These conditions can affect people of all ages, though many begin in childhood or earl