Overview
Pyomyositis is a bacterial infection that develops deep inside the muscles of the body. It is sometimes called tropical pyomyositis or spontaneous bacterial myositis. The infection causes pus to collect inside the muscle tissue, forming one or more abscesses. While it was once thought to be rare and mainly seen in tropical regions, it is now recognized worldwide, especially in people with weakened immune systems. The disease usually affects large muscles, most often in the thighs, buttocks, or upper arms. It tends to develop in three stages. In the early stage, the muscle feels sore and slightly swollen. As the infection grows, the area becomes more painful, swollen, and tender. In the late stage, a full abscess forms, and the person may develop fever, chills, and signs of serious infection spreading through the body. Treatment involves draining the abscess and using antibiotics, most often targeting Staphylococcus aureus, the bacteria responsible in the majority of cases. With prompt treatment, most people recover fully. However, if the infection is caught late or spreads to the bloodstream, it can become life-threatening. Early diagnosis is key to a good outcome.
Also known as:
Key symptoms:
Deep muscle pain, often in the thigh, buttock, or upper armSwelling and firmness in the affected muscleFever and chillsRedness and warmth over the skin above the infected muscleDifficulty moving the affected limbFatigue and feeling generally unwellTenderness when pressing on the musclePus-filled abscess inside the muscle (seen on imaging)Night sweatsMuscle weakness in the affected area
Clinical phenotype terms (12)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
Treatments
1 availableDyural 80-Lm
nonsupportive thyroiditis
Clinical Trials
View all trials with filters →No actively recruiting trials found for Pyomyositis at this time.
New trials open frequently. Follow this disease to get notified.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Pyomyositis.
Community
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Start the conversation →Latest news about Pyomyositis
1 articlesCaregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What bacteria caused my infection, and is it resistant to any antibiotics?,Do I need surgery to drain the abscess, or can it be drained with a needle?,How long will I need to take antibiotics, and will I need them through a drip or can I take tablets?,Do I have an underlying condition that made me more likely to get this infection?,How will we know the treatment is working, and what follow-up tests or scans do I need?,What warning signs should I watch for that would mean I need to come back to the hospital urgently?,Is there a risk this infection could come back, and how can I reduce that risk?
Common questions about Pyomyositis
What is Pyomyositis?
Pyomyositis is a bacterial infection that develops deep inside the muscles of the body. It is sometimes called tropical pyomyositis or spontaneous bacterial myositis. The infection causes pus to collect inside the muscle tissue, forming one or more abscesses. While it was once thought to be rare and mainly seen in tropical regions, it is now recognized worldwide, especially in people with weakened immune systems. The disease usually affects large muscles, most often in the thighs, buttocks, or upper arms. It tends to develop in three stages. In the early stage, the muscle feels sore and sligh
How is Pyomyositis inherited?
Pyomyositis follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Which specialists treat Pyomyositis?
2 specialists and care centers treating Pyomyositis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.