Pyomyositis

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1FDA treatments2Specialists8Treatment centers

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Overview

Pyomyositis is a bacterial infection that develops deep inside the muscles of the body. It is sometimes called tropical pyomyositis or spontaneous bacterial myositis. The infection causes pus to collect inside the muscle tissue, forming one or more abscesses. While it was once thought to be rare and mainly seen in tropical regions, it is now recognized worldwide, especially in people with weakened immune systems. The disease usually affects large muscles, most often in the thighs, buttocks, or upper arms. It tends to develop in three stages. In the early stage, the muscle feels sore and slightly swollen. As the infection grows, the area becomes more painful, swollen, and tender. In the late stage, a full abscess forms, and the person may develop fever, chills, and signs of serious infection spreading through the body. Treatment involves draining the abscess and using antibiotics, most often targeting Staphylococcus aureus, the bacteria responsible in the majority of cases. With prompt treatment, most people recover fully. However, if the infection is caught late or spreads to the bloodstream, it can become life-threatening. Early diagnosis is key to a good outcome.

Also known as:

Key symptoms:

Deep muscle pain, often in the thigh, buttock, or upper armSwelling and firmness in the affected muscleFever and chillsRedness and warmth over the skin above the infected muscleDifficulty moving the affected limbFatigue and feeling generally unwellTenderness when pressing on the musclePus-filled abscess inside the muscle (seen on imaging)Night sweatsMuscle weakness in the affected area

Clinical phenotype terms (12)— hover any for plain English
MyositisHP:0100614Testicular teratomaHP:0100616Recurrent cutaneous abscess formationHP:0100838
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

Treatments

1 available

Dyural 80-Lm

METHYLPREDNISOLONE ACETATE, LIDOCAINE HYDROCHLORIDE, BUPIVACAINE HYDROCHLORIDE, POVIDINE IODINE, ISOPROPYL ALCOHOL· Advanced Rx Pharmacy of Tennessee, LLC■ Boxed Warning

nonsupportive thyroiditis

No actively recruiting trials found for Pyomyositis at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Pyomyositis community →

Specialists

2 foundView all specialists →
AM
Andrew Haynes, MD
Specialist
PI on 1 active trial1 Pyomyositis publication
JM
Jack G Schneider, MD
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Pyomyositis.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Pyomyositis

1 articles
NewsCLINICALTRIALS.GOVJan 28, 2026
New recruiting trial: MIHRA - Patient-Rooted Insights for Shaping Myositis Science (PRISMS)
Myositis diseases are each rare diseases. As in other rare diseases, people living with myositis diseases face physical and psychosocial challenges that may not
See all news about Pyomyositis

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What bacteria caused my infection, and is it resistant to any antibiotics?,Do I need surgery to drain the abscess, or can it be drained with a needle?,How long will I need to take antibiotics, and will I need them through a drip or can I take tablets?,Do I have an underlying condition that made me more likely to get this infection?,How will we know the treatment is working, and what follow-up tests or scans do I need?,What warning signs should I watch for that would mean I need to come back to the hospital urgently?,Is there a risk this infection could come back, and how can I reduce that risk?

Common questions about Pyomyositis

What is Pyomyositis?

Pyomyositis is a bacterial infection that develops deep inside the muscles of the body. It is sometimes called tropical pyomyositis or spontaneous bacterial myositis. The infection causes pus to collect inside the muscle tissue, forming one or more abscesses. While it was once thought to be rare and mainly seen in tropical regions, it is now recognized worldwide, especially in people with weakened immune systems. The disease usually affects large muscles, most often in the thighs, buttocks, or upper arms. It tends to develop in three stages. In the early stage, the muscle feels sore and sligh

How is Pyomyositis inherited?

Pyomyositis follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

Which specialists treat Pyomyositis?

2 specialists and care centers treating Pyomyositis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.