Pulmonary nodular lymphoid hyperplasia

Pulmonary nodular lymphoid hyperplasia (PNLH) is a rare, benign condition where clusters of immune cells called lymphocytes grow and form small nodules (lumps) in the lung tissue. It is sometimes called pulmonary lymphoid hyperplasia or nodular lymphoid lesion of the lung. These nodules are not cancerous, but they can look similar to other lung conditions on scans, which makes diagnosis tricky. The condition belongs to a group of lung disorders involving abnormal but non-cancerous growth of lymphoid (immune) tissue. Many people with PNLH have no symptoms at all and the nodules are found by accident during a chest X-ray or CT scan done for another reason. When symptoms do occur, they can include a mild cough, shortness of breath, or a general feeling of chest discomfort. Some patients have an underlying autoimmune condition or immune system problem, such as Sjögren's syndrome or common variable immunodeficiency (CVID), which may be linked to the development of PNLH. Treatment depends on how severe the condition is and whether symptoms are present. Many patients are simply monitored over time with regular imaging. When treatment is needed, corticosteroids (anti-inflammatory medicines) are often used. In some cases, the nodules are surgically removed, both to confirm the diagnosis and to treat the condition. The overall outlook is generally good, especially when there is no underlying serious immune disorder. Regular follow-up with a lung specialist is important to watch for any changes.

Bring these to your next appointment

• Q1.Is my diagnosis of PNLH confirmed by biopsy, and has lymphoma been fully ruled out?,Do I need treatment right now, or is a watch-and-wait approach appropriate for me?,Should I be tested for an underlying autoimmune condition or immune deficiency?,How often do I need follow-up CT scans, and what changes should prompt me to call you sooner?,What symptoms should make me go to the emergency room?,Are there any clinical trials or specialist centers I should consider?,Will this condition affect my ability to work or exercise long-term?

Common questions about Pulmonary nodular lymphoid hyperplasia