Overview
Progeroid syndrome, Petty type, is an extremely rare genetic condition that causes features of premature aging (progeria) along with problems affecting the bones, joints, and connective tissues. This condition was first described by Dr. Petty and colleagues, and only a handful of cases have been reported in the medical literature. People with this syndrome may show signs of accelerated aging such as thin skin, loss of fat under the skin, and a distinctive facial appearance. They may also have joint problems including joint contractures (stiffness that limits movement), short stature, and skeletal abnormalities. Some individuals may develop problems with their eyes, such as cataracts, and may have thin or sparse hair. Because this condition is so rare, there is no specific cure or targeted treatment available. Management focuses on treating individual symptoms as they arise. This may include physical therapy for joint problems, orthopedic care for bone issues, eye care for vision problems, and regular monitoring by multiple specialists. Genetic counseling is recommended for affected families to understand the inheritance pattern and recurrence risk. The rarity of this condition means that much remains unknown about its full spectrum of symptoms and long-term outlook, and patients benefit from being followed at centers experienced with progeroid syndromes.
Also known as:
Key symptoms:
Premature aging appearanceShort stature or growth delayJoint stiffness or contracturesThin or aged-looking skinLoss of fat under the skinSparse or thin hairDistinctive facial featuresSkeletal abnormalitiesCataracts or other eye problemsWide or open fontanelles in infancyDelayed closure of skull bonesWrinkled skinSmall jaw (micrognathia)Fragile or easily damaged skin
Clinical phenotype terms (28)— hover any for plain English
Autosomal recessive
Passed on when both parents carry the same gene change; often skips generations
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for Progeroid syndrome, Petty type.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Progeroid syndrome, Petty type at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for Progeroid syndrome, Petty type.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Progeroid syndrome, Petty type.
Community
No community posts yet. Be the first to share your experience with Progeroid syndrome, Petty type.
Start the conversation →Latest news about Progeroid syndrome, Petty type
No recent news articles for Progeroid syndrome, Petty type.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What specific symptoms should I watch for as my child grows?,Is genetic testing available to confirm the diagnosis, and should other family members be tested?,What therapies can help maintain joint mobility and prevent contractures?,How often should my child have eye exams and bone health assessments?,Are there any clinical trials or research studies we could participate in?,What is the expected long-term outlook for someone with this condition?,Can you connect us with other families or support groups for progeroid syndromes?
Common questions about Progeroid syndrome, Petty type
What is Progeroid syndrome, Petty type?
Progeroid syndrome, Petty type, is an extremely rare genetic condition that causes features of premature aging (progeria) along with problems affecting the bones, joints, and connective tissues. This condition was first described by Dr. Petty and colleagues, and only a handful of cases have been reported in the medical literature. People with this syndrome may show signs of accelerated aging such as thin skin, loss of fat under the skin, and a distinctive facial appearance. They may also have joint problems including joint contractures (stiffness that limits movement), short stature, and skele
How is Progeroid syndrome, Petty type inherited?
Progeroid syndrome, Petty type follows a autosomal recessive inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Progeroid syndrome, Petty type typically begin?
Typical onset of Progeroid syndrome, Petty type is neonatal. Age of onset can vary across affected individuals.