Pediatric arterial ischemic stroke

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2Active trials20Specialists8Treatment centers

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Pediatric arterial ischemic stroke (also called childhood stroke or pediatric AIS) is a condition in which a blood clot blocks an artery that supplies blood to the brain in a child. When blood flow is cut off, brain cells in the affected area begin to die, which can cause sudden neurological problems. This condition can happen at any age during childhood, from newborns through teenagers, and it is different from stroke in adults because the causes, risk factors, and recovery patterns are unique to children. Symptoms typically come on suddenly and may include weakness or numbness on one side of the body, trouble speaking or understanding speech, severe headache, vision changes, difficulty walking, or seizures. In babies and very young children, the signs can be harder to recognize and may include seizures, extreme sleepiness, or favoring one side of the body. The causes of pediatric arterial ischemic stroke are varied and often multifactorial. Common risk factors include heart disease (especially congenital heart defects), sickle cell disease, infections, blood clotting disorders, moyamoya disease, and abnormalities of the blood vessels. In some cases, no clear cause is found. Treatment focuses on emergency care to restore blood flow, preventing future strokes, and rehabilitation to help the child recover lost abilities. While children generally have better brain recovery potential than adults due to brain plasticity, many children are left with lasting effects such as weakness, learning difficulties, or epilepsy. A multidisciplinary team approach involving neurologists, hematologists, rehabilitation specialists, and others is essential for the best outcomes.

Also known as:

Key symptoms:

Sudden weakness or numbness on one side of the bodyDifficulty speaking or understanding wordsSudden severe headacheVision loss or changes in one or both eyesTrouble walking or loss of balanceSeizuresDrooping of one side of the faceConfusion or difficulty thinking clearlyExtreme sleepiness or difficulty waking up (especially in infants)Favoring one hand or one side of the body in babiesDifficulty swallowingBehavior changesMemory problems

Inheritance

Multifactorial

Caused by a mix of several genes and environmental factors

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

FDA & Trial Timeline

5 events
Mar 2026Evaluation of a Point-of-care Lateral Flow Assay in Glial Fibrillary Acidic Protein (GFAP) and D-dimer in Diagnosis of Large Vessel Occlusion Acute Ischemic Stroke in a Pediatric Hospital

Boston Children's Hospital

TrialNOT YET RECRUITING
Oct 2023Focal Cerebral Arteriopathy Steroid Trial

University of California, San Francisco — PHASE4

TrialENROLLING BY INVITATION
Jan 2021Randomized Study in Children and Adolescents With Migraine: Acute Treatment

Pfizer — PHASE3

TrialRECRUITING
Feb 2017Investigating How Childhood Tumours and Congenital Disease Develop

The Wellcome Sanger Institute — NA

TrialENROLLING BY INVITATION
Jan 2003Database for Stroke in Infants and Children: the International Pediatric Stroke Study

The Hospital for Sick Children

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Pediatric arterial ischemic stroke.

2 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

2 recruitingView all trials with filters →
Phase 41 trial
Focal Cerebral Arteriopathy Steroid Trial
Phase 4
Enrolling by Invitation
PI: Heather J Fullerton, MD, MAS (University of California, San Francisco) · Sites: San Francisco, California · Age: 118 yrs
Other1 trial
Database for Stroke in Infants and Children: the International Pediatric Stroke Study
Actively Recruiting
PI: Nomazulu Dlamini, MD (The Hospital for Sick Children) · Sites: Toronto, Ontario · Age: 018 yrs

Specialists

20 foundView all specialists →
MD
Michael Ditchfield
EDGARTOWN, MA
Specialist
2 Pediatric arterial ischemic stroke publications
PM
Paul Monagle
Specialist
2 Pediatric arterial ischemic stroke publications
VA
Vicki Anderson
Specialist
2 Pediatric arterial ischemic stroke publications
KB
Kartik D Bhatia
Specialist
2 Pediatric arterial ischemic stroke publications
PM
Prakash Muthusami
Specialist
2 Pediatric arterial ischemic stroke publications
CP
Carmen Parra-Farinas
Specialist
2 Pediatric arterial ischemic stroke publications
LS
Lisa R Sun
Specialist
3 Pediatric arterial ischemic stroke publications
SL
Sarah Lee
Specialist
3 Pediatric arterial ischemic stroke publications
ND
Nomazulu Dlamini
Specialist
3 Pediatric arterial ischemic stroke publications
MG
Mardee Greenham
Specialist
2 Pediatric arterial ischemic stroke publications
AG
Anne L Gordon
Specialist
2 Pediatric arterial ischemic stroke publications
AC
Anna Cooper
Specialist
2 Pediatric arterial ischemic stroke publications
LC
Lee Coleman
Specialist
2 Pediatric arterial ischemic stroke publications
RH
Rod W Hunt
JACKSON, MS
Specialist
2 Pediatric arterial ischemic stroke publications
MM
Mark T Mackay
BROADWAY, VA
Specialist
2 Pediatric arterial ischemic stroke publications
MP
Manoelle Kossorotoff, MD, PhD
Specialist
PI on 1 active trial
NM
Nomazulu Dlamini, MD
Specialist
PI on 1 active trial
WM
Warren Lo, MD
COLUMBUS, OH
Specialist
PI on 1 active trial1 Pediatric arterial ischemic stroke publication
SP
Sam Behjati, PhD
Cambridge
Specialist

Rare Disease Specialist

HF
Heather J Fullerton
SAN FRANCISCO, CA
Specialist
PI on 1 active trial

Treatment Centers

8 centers
⚗️ Trial Site

Children's Hospital of Orange County

📍 Orange, California

👤 Richard Neibeger, MD

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

Travel Grants

No travel grants are currently matched to Pediatric arterial ischemic stroke.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Pediatric arterial ischemic stroke

1 articles
Clinical trialUNITERAREApr 3, 2026
New Recruiting Trial: Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project)
Researchers are testing a new technology called 'digital twins' to help prevent second strokes in patients with three rare brain conditions: moyamoya disease, c
See all news about Pediatric arterial ischemic stroke

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What caused my child's stroke, and can we prevent it from happening again?,Does my child need to take blood thinners or aspirin, and for how long?,What rehabilitation therapies does my child need, and how often?,Should my child be tested for genetic blood clotting disorders or other underlying conditions?,What are the signs of another stroke, and what should I do if I see them?,How will this stroke affect my child's learning and development, and what school supports should we request?,Are there any activities or sports my child should avoid?

Common questions about Pediatric arterial ischemic stroke

What is Pediatric arterial ischemic stroke?

Pediatric arterial ischemic stroke (also called childhood stroke or pediatric AIS) is a condition in which a blood clot blocks an artery that supplies blood to the brain in a child. When blood flow is cut off, brain cells in the affected area begin to die, which can cause sudden neurological problems. This condition can happen at any age during childhood, from newborns through teenagers, and it is different from stroke in adults because the causes, risk factors, and recovery patterns are unique to children. Symptoms typically come on suddenly and may include weakness or numbness on one side o

How is Pediatric arterial ischemic stroke inherited?

Pediatric arterial ischemic stroke follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

Are there clinical trials for Pediatric arterial ischemic stroke?

Yes — 2 recruiting clinical trials are currently listed for Pediatric arterial ischemic stroke on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Pediatric arterial ischemic stroke?

20 specialists and care centers treating Pediatric arterial ischemic stroke are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.