Overview
Pediatric arterial ischemic stroke (also called childhood stroke or pediatric AIS) is a condition in which a blood clot blocks an artery that supplies blood to the brain in a child. When blood flow is cut off, brain cells in the affected area begin to die, which can cause sudden neurological problems. This condition can happen at any age during childhood, from newborns through teenagers, and it is different from stroke in adults because the causes, risk factors, and recovery patterns are unique to children. Symptoms typically come on suddenly and may include weakness or numbness on one side of the body, trouble speaking or understanding speech, severe headache, vision changes, difficulty walking, or seizures. In babies and very young children, the signs can be harder to recognize and may include seizures, extreme sleepiness, or favoring one side of the body. The causes of pediatric arterial ischemic stroke are varied and often multifactorial. Common risk factors include heart disease (especially congenital heart defects), sickle cell disease, infections, blood clotting disorders, moyamoya disease, and abnormalities of the blood vessels. In some cases, no clear cause is found. Treatment focuses on emergency care to restore blood flow, preventing future strokes, and rehabilitation to help the child recover lost abilities. While children generally have better brain recovery potential than adults due to brain plasticity, many children are left with lasting effects such as weakness, learning difficulties, or epilepsy. A multidisciplinary team approach involving neurologists, hematologists, rehabilitation specialists, and others is essential for the best outcomes.
Key symptoms:
Sudden weakness or numbness on one side of the bodyDifficulty speaking or understanding wordsSudden severe headacheVision loss or changes in one or both eyesTrouble walking or loss of balanceSeizuresDrooping of one side of the faceConfusion or difficulty thinking clearlyExtreme sleepiness or difficulty waking up (especially in infants)Favoring one hand or one side of the body in babiesDifficulty swallowingBehavior changesMemory problems
Multifactorial
Caused by a mix of several genes and environmental factors
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
5 eventsBoston Children's Hospital
University of California, San Francisco — PHASE4
Pfizer — PHASE3
The Wellcome Sanger Institute — NA
The Hospital for Sick Children
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Pediatric arterial ischemic stroke.
2 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Rare Disease Specialist
Treatment Centers
8 centersChildren's Hospital of Orange County
📍 Orange, California
👤 Richard Neibeger, MD
Stanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🏥 NORDBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
Travel Grants
No travel grants are currently matched to Pediatric arterial ischemic stroke.
Community
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Questions for your doctor
Bring these to your next appointment
- Q1.What caused my child's stroke, and can we prevent it from happening again?,Does my child need to take blood thinners or aspirin, and for how long?,What rehabilitation therapies does my child need, and how often?,Should my child be tested for genetic blood clotting disorders or other underlying conditions?,What are the signs of another stroke, and what should I do if I see them?,How will this stroke affect my child's learning and development, and what school supports should we request?,Are there any activities or sports my child should avoid?
Common questions about Pediatric arterial ischemic stroke
What is Pediatric arterial ischemic stroke?
Pediatric arterial ischemic stroke (also called childhood stroke or pediatric AIS) is a condition in which a blood clot blocks an artery that supplies blood to the brain in a child. When blood flow is cut off, brain cells in the affected area begin to die, which can cause sudden neurological problems. This condition can happen at any age during childhood, from newborns through teenagers, and it is different from stroke in adults because the causes, risk factors, and recovery patterns are unique to children. Symptoms typically come on suddenly and may include weakness or numbness on one side o
How is Pediatric arterial ischemic stroke inherited?
Pediatric arterial ischemic stroke follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Are there clinical trials for Pediatric arterial ischemic stroke?
Yes — 2 recruiting clinical trials are currently listed for Pediatric arterial ischemic stroke on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Pediatric arterial ischemic stroke?
20 specialists and care centers treating Pediatric arterial ischemic stroke are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.