Papular elastorrhexis

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ORPHA:228264L98.8
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15Specialists8Treatment centers

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Papular elastorrhexis is a rare, benign connective tissue disorder of the skin characterized by the appearance of small, firm, non-follicular, white to skin-colored papules distributed primarily on the trunk, particularly the back, chest, and upper extremities. The condition results from a loss or fragmentation of elastic fibers in the dermis, a finding confirmed on histological examination. The papules are typically asymptomatic (not painful or itchy) and are usually 1–5 mm in diameter. Papular elastorrhexis predominantly affects the integumentary system (skin) and does not involve internal organs. The condition most commonly presents in adolescence or young adulthood and tends to remain stable over time. It has been debated whether papular elastorrhexis represents a distinct entity or falls within the spectrum of connective tissue nevi, particularly the collagenous type. Some authors consider it closely related to or overlapping with disseminated eruptive collagenomas. The exact cause remains unclear, and most reported cases appear to be sporadic, with no clear familial inheritance pattern identified in the majority of cases. There is no established curative treatment for papular elastorrhexis. Management is primarily cosmetic and reassurance-based, as the condition is benign and does not progress to systemic disease. Some case reports have described partial improvement with treatments such as topical retinoids or laser therapy, but evidence for efficacy is limited and largely anecdotal. Patients are generally advised that the condition poses no health risk, though the cosmetic appearance may be a concern for some individuals.

Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Juvenile

Begins in the teen years

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Papular elastorrhexis.

View clinical trials →

No actively recruiting trials found for Papular elastorrhexis at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Papular elastorrhexis community →

Specialists

15 foundView all specialists →
JZ
Jianzhong Zhang
HAMPTON, VA
Specialist
1 Papular elastorrhexis publication
ZC
Zhou Chen
DALLAS, TX
Specialist
1 Papular elastorrhexis publication
ML
M Luque-Luna
Specialist
1 Papular elastorrhexis publication
CA
C Albanell-Fernández
Specialist
1 Papular elastorrhexis publication
PC
P Castillo
Specialist
1 Papular elastorrhexis publication
GE
G Espinosa
Specialist
1 Papular elastorrhexis publication
JM
J M Mascaró
Specialist
1 Papular elastorrhexis publication
TR
Tulika Rai
Specialist
1 Papular elastorrhexis publication
AN
Anisha Najeeb
Specialist
1 Papular elastorrhexis publication
PJ
Prasanna Jha
Specialist
1 Papular elastorrhexis publication
XY
Xiaojing Yang
Specialist
1 Papular elastorrhexis publication
XL
Xuan Lei
Specialist
1 Papular elastorrhexis publication
PA
Pooja Arora
Specialist
1 Papular elastorrhexis publication
JG
J Gil-Lianes
Specialist
1 Papular elastorrhexis publication
MB
Meenakshi Batrani
Specialist
1 Papular elastorrhexis publication

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Papular elastorrhexis.

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Caregiver Resources

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Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Papular elastorrhexis

What is Papular elastorrhexis?

Papular elastorrhexis is a rare, benign connective tissue disorder of the skin characterized by the appearance of small, firm, non-follicular, white to skin-colored papules distributed primarily on the trunk, particularly the back, chest, and upper extremities. The condition results from a loss or fragmentation of elastic fibers in the dermis, a finding confirmed on histological examination. The papules are typically asymptomatic (not painful or itchy) and are usually 1–5 mm in diameter. Papular elastorrhexis predominantly affects the integumentary system (skin) and does not involve internal o

How is Papular elastorrhexis inherited?

Papular elastorrhexis follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Papular elastorrhexis typically begin?

Typical onset of Papular elastorrhexis is juvenile. Age of onset can vary across affected individuals.

Which specialists treat Papular elastorrhexis?

15 specialists and care centers treating Papular elastorrhexis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.