Overview
Papular elastorrhexis is a rare, benign connective tissue disorder of the skin characterized by the appearance of small, firm, non-follicular, white to skin-colored papules distributed primarily on the trunk, particularly the back, chest, and upper extremities. The condition results from a loss or fragmentation of elastic fibers in the dermis, a finding confirmed on histological examination. The papules are typically asymptomatic (not painful or itchy) and are usually 1–5 mm in diameter. Papular elastorrhexis predominantly affects the integumentary system (skin) and does not involve internal organs. The condition most commonly presents in adolescence or young adulthood and tends to remain stable over time. It has been debated whether papular elastorrhexis represents a distinct entity or falls within the spectrum of connective tissue nevi, particularly the collagenous type. Some authors consider it closely related to or overlapping with disseminated eruptive collagenomas. The exact cause remains unclear, and most reported cases appear to be sporadic, with no clear familial inheritance pattern identified in the majority of cases. There is no established curative treatment for papular elastorrhexis. Management is primarily cosmetic and reassurance-based, as the condition is benign and does not progress to systemic disease. Some case reports have described partial improvement with treatments such as topical retinoids or laser therapy, but evidence for efficacy is limited and largely anecdotal. Patients are generally advised that the condition poses no health risk, though the cosmetic appearance may be a concern for some individuals.
Sporadic
Usually appears on its own, not inherited from a parent
Juvenile
Begins in the teen years
Treatments
No FDA-approved treatments are currently listed for Papular elastorrhexis.
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Papular elastorrhexis.
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Common questions about Papular elastorrhexis
What is Papular elastorrhexis?
Papular elastorrhexis is a rare, benign connective tissue disorder of the skin characterized by the appearance of small, firm, non-follicular, white to skin-colored papules distributed primarily on the trunk, particularly the back, chest, and upper extremities. The condition results from a loss or fragmentation of elastic fibers in the dermis, a finding confirmed on histological examination. The papules are typically asymptomatic (not painful or itchy) and are usually 1–5 mm in diameter. Papular elastorrhexis predominantly affects the integumentary system (skin) and does not involve internal o
How is Papular elastorrhexis inherited?
Papular elastorrhexis follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Papular elastorrhexis typically begin?
Typical onset of Papular elastorrhexis is juvenile. Age of onset can vary across affected individuals.
Which specialists treat Papular elastorrhexis?
15 specialists and care centers treating Papular elastorrhexis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.