Overview
Palmoplantar porokeratosis of Mantoux (also called porokeratosis palmaris et plantaris disseminata, or PPPD) is a rare inherited skin disorder that belongs to a group of conditions called porokeratoses. In this condition, the skin develops small, ring-shaped or pit-like lesions — most commonly on the palms of the hands and the soles of the feet, though they can spread to other parts of the body over time. These lesions form because skin cells do not grow and shed in a normal, orderly way. A raised, thread-like border called a 'cornoid lamella' surrounds each lesion, which is a hallmark feature seen under a microscope. The condition usually begins in adolescence or early adulthood and tends to slowly get worse over the years. The lesions can cause discomfort, itching, or a burning sensation, and some people find them cosmetically distressing. In rare cases, long-standing lesions may develop into skin cancer, so regular skin monitoring is important. There is currently no cure for palmoplantar porokeratosis of Mantoux. Treatment focuses on managing symptoms and reducing the appearance of lesions. Options include moisturizing creams, retinoids (vitamin A-based medicines), topical treatments to remove thickened skin, and sun protection. Regular check-ups with a dermatologist are strongly recommended to watch for any changes that might suggest cancer development.
Key symptoms:
Small, ring-shaped or pit-like lesions on the palms and solesRaised, thread-like border around each skin lesionItching or burning sensation in affected areasSkin lesions that may slowly spread to other body areas over timeThickened or rough skin patchesDiscomfort when walking if lesions are on the soles of the feetCosmetically noticeable skin changes on hands and feetPossible development of new lesions during sun exposure or illness
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Juvenile
Begins in the teen years
Treatments
No FDA-approved treatments are currently listed for Palmoplantar porokeratosis of Mantoux.
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Specialists
View all specialists →No specialists are currently listed for Palmoplantar porokeratosis of Mantoux.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Palmoplantar porokeratosis of Mantoux.
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Caregiver Resources
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Questions for your doctor
Bring these to your next appointment
- Q1.How certain are you that this is palmoplantar porokeratosis of Mantoux, and should I have a skin biopsy to confirm?,Should I have genetic testing, and what does a positive result mean for my family members?,What is the risk that my lesions could become cancerous, and how often should I be checked?,What treatments do you recommend for my specific situation, and what are the side effects?,Are there any activities, foods, or environmental factors I should avoid to prevent my condition from getting worse?,Should my children or siblings be examined or tested for this condition?,Are there any clinical trials or new treatments I should know about?
Common questions about Palmoplantar porokeratosis of Mantoux
What is Palmoplantar porokeratosis of Mantoux?
Palmoplantar porokeratosis of Mantoux (also called porokeratosis palmaris et plantaris disseminata, or PPPD) is a rare inherited skin disorder that belongs to a group of conditions called porokeratoses. In this condition, the skin develops small, ring-shaped or pit-like lesions — most commonly on the palms of the hands and the soles of the feet, though they can spread to other parts of the body over time. These lesions form because skin cells do not grow and shed in a normal, orderly way. A raised, thread-like border called a 'cornoid lamella' surrounds each lesion, which is a hallmark feature
How is Palmoplantar porokeratosis of Mantoux inherited?
Palmoplantar porokeratosis of Mantoux follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Palmoplantar porokeratosis of Mantoux typically begin?
Typical onset of Palmoplantar porokeratosis of Mantoux is juvenile. Age of onset can vary across affected individuals.