Overview
Other genetic dermis disorder (Orphanet code 477808) is a broad category that covers rare inherited conditions affecting the dermis — the deep layer of skin beneath the surface. The dermis contains important structures like collagen fibers, elastic fibers, blood vessels, and nerve endings that give skin its strength, flexibility, and ability to heal. When genes that control how the dermis is built or maintained are altered, the skin may become fragile, unusually stretchy, prone to scarring, or slow to heal. Some conditions in this group also affect connective tissue in other parts of the body, such as joints, blood vessels, and internal organs. Symptoms vary widely depending on the specific genetic change involved. Common features include skin that bruises easily, wounds that heal poorly or leave unusual scars, skin that feels unusually soft or doughy, and sometimes joint hypermobility. Because this is a grouping of several distinct but related disorders, the exact symptoms, severity, and organs affected depend on the underlying genetic cause. Treatment is generally focused on managing symptoms and preventing complications, since most of these conditions do not yet have a cure. Care teams typically include dermatologists, clinical geneticists, and other specialists depending on which body systems are involved. Early diagnosis is important to help protect the skin, avoid injury, and improve quality of life.
Key symptoms:
Skin that bruises very easilyWounds that are slow to heal or heal with unusual scarsSkin that feels unusually soft, stretchy, or fragileAbnormal or raised scarring (keloids or atrophic scars)Skin that tears or blisters with minor injuryJoint hypermobility (joints that bend further than normal)Skin that sags or hangs looselyChronic skin pain or sensitivityRecurrent skin infections due to poor healingChanges in skin texture or thickness
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for Other genetic dermis disorder.
View clinical trials →Clinical Trials
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Specialists
View all specialists →No specialists are currently listed for Other genetic dermis disorder.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Other genetic dermis disorder.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Which specific genetic dermis disorder do I have, and what gene is involved?,What parts of my body beyond the skin could be affected?,What activities or situations should I avoid to protect my skin?,Are there any clinical trials or new treatments I should know about?,Should my family members be tested for the same condition?,What is the best way to care for wounds at home?,Are there patient support groups or resources you recommend for this condition?
Common questions about Other genetic dermis disorder
What is Other genetic dermis disorder?
Other genetic dermis disorder (Orphanet code 477808) is a broad category that covers rare inherited conditions affecting the dermis — the deep layer of skin beneath the surface. The dermis contains important structures like collagen fibers, elastic fibers, blood vessels, and nerve endings that give skin its strength, flexibility, and ability to heal. When genes that control how the dermis is built or maintained are altered, the skin may become fragile, unusually stretchy, prone to scarring, or slow to heal. Some conditions in this group also affect connective tissue in other parts of the body,