Overview
X-linked intellectual disability, Raynaud type (also known as Raynaud-Claes syndrome) is an extremely rare genetic condition that was originally described in a small number of families. This condition is now classified as 'obsolete' in medical databases, meaning it has either been reclassified under a different name, merged with another recognized condition, or its original description has been updated as genetic knowledge has advanced. The condition was characterized by intellectual disability occurring primarily in males, consistent with an X-linked pattern of inheritance. Affected individuals were reported to have developmental delays, learning difficulties, and varying degrees of intellectual impairment. Some descriptions also noted additional features such as behavioral challenges and possible physical differences, though the clinical picture was not well defined due to the very small number of reported cases. Because this entry is now considered obsolete, patients or families who were previously given this diagnosis should consult with a clinical geneticist to determine whether a more current and specific diagnosis applies to their situation. Modern genetic testing, including whole exome or genome sequencing, may help identify the precise genetic cause and lead to a more accurate diagnosis. Treatment has generally been supportive, focusing on educational support, behavioral therapies, and addressing any associated medical needs on an individual basis.
Key symptoms:
Intellectual disabilityDelayed speech and language developmentLearning difficultiesBehavioral challengesDelayed developmental milestonesDifficulty with problem-solving and reasoning
X-linked recessive
Carried on the X chromosome; typically affects males more than females
Childhood
Begins in childhood, roughly ages 1 to 12
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: X-linked intellectual disability, Raynaud type.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for OBSOLETE: X-linked intellectual disability, Raynaud type at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for OBSOLETE: X-linked intellectual disability, Raynaud type.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: X-linked intellectual disability, Raynaud type.
Community
No community posts yet. Be the first to share your experience with OBSOLETE: X-linked intellectual disability, Raynaud type.
Start the conversation →Latest news about OBSOLETE: X-linked intellectual disability, Raynaud type
No recent news articles for OBSOLETE: X-linked intellectual disability, Raynaud type.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is this diagnosis still considered accurate, or should we pursue updated genetic testing?,What modern genetic tests would you recommend to find a more specific diagnosis?,What therapies and early interventions would benefit my child the most right now?,Are there any clinical trials or research studies we should know about?,What level of independence can we expect as my child grows older?,Should other family members, especially females who may be carriers, be tested?,How often should we schedule follow-up evaluations to track development?
Common questions about OBSOLETE: X-linked intellectual disability, Raynaud type
What is OBSOLETE: X-linked intellectual disability, Raynaud type?
X-linked intellectual disability, Raynaud type (also known as Raynaud-Claes syndrome) is an extremely rare genetic condition that was originally described in a small number of families. This condition is now classified as 'obsolete' in medical databases, meaning it has either been reclassified under a different name, merged with another recognized condition, or its original description has been updated as genetic knowledge has advanced. The condition was characterized by intellectual disability occurring primarily in males, consistent with an X-linked pattern of inheritance. Affected individua
How is OBSOLETE: X-linked intellectual disability, Raynaud type inherited?
OBSOLETE: X-linked intellectual disability, Raynaud type follows a x-linked recessive inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: X-linked intellectual disability, Raynaud type typically begin?
Typical onset of OBSOLETE: X-linked intellectual disability, Raynaud type is childhood. Age of onset can vary across affected individuals.