OBSOLETE: Vibratory angioedema

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ORPHA:493348
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Overview

Vibratory angioedema is a rare condition where the skin reacts to vibration by swelling up. When something vibrates against the skin — like a lawnmower, a power tool, jogging, clapping, or even riding in a car — the body releases chemicals that cause swelling, redness, and itching in the area that was touched. This swelling is called angioedema, and in this condition it is specifically triggered by vibration. The condition is also sometimes called 'vibratory urticaria' because hives (urticaria) can appear alongside the swelling. The swelling usually happens within minutes of the vibration and goes away on its own within about an hour. It most often affects the hands, arms, and other areas that come into direct contact with vibrating surfaces. In most cases the reaction stays local, but in some people it can cause more widespread symptoms like flushing, headache, or a general feeling of being unwell. It is worth noting that Orphanet has marked this condition as 'obsolete,' meaning it may now be classified under a broader category such as inducible urticaria or physical urticaria. Treatment usually involves antihistamines to reduce symptoms and avoiding vibration triggers as much as possible. The condition is not life-threatening in most cases, but it can significantly affect daily activities and quality of life.

Key symptoms:

Swelling of the skin after vibration exposureHives or raised red welts on the skinItching or burning where vibration touched the skinRedness of the skin in the affected areaFlushing or warmth spreading across the bodyHeadache after vibration exposureFeeling generally unwell or tired after a reactionSwelling that appears within minutes and fades within an hour

Inheritance

Autosomal dominant

Passed on from just one parent; each child has about a 50% chance of inheriting it

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for OBSOLETE: Vibratory angioedema.

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No actively recruiting trials found for OBSOLETE: Vibratory angioedema at this time.

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Search ClinicalTrials.gov ↗Join the OBSOLETE: Vibratory angioedema community →

No specialists are currently listed for OBSOLETE: Vibratory angioedema.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to OBSOLETE: Vibratory angioedema.

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Community

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Caregiver Resources

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Questions for your doctor

Bring these to your next appointment

  • Q1.Should I carry an epinephrine auto-injector in case of a severe reaction?,Which antihistamine is best for me, and should I take it every day or only before exposure?,Is omalizumab (Xolair) an option for my level of symptoms?,Should other family members be tested or evaluated for this condition?,Are there any activities I absolutely must avoid, and which ones are safe with precautions?,How do I know if my reaction is becoming dangerous and when should I go to the emergency room?,Is there a specialist center or clinical trial I should know about?

Common questions about OBSOLETE: Vibratory angioedema

What is OBSOLETE: Vibratory angioedema?

Vibratory angioedema is a rare condition where the skin reacts to vibration by swelling up. When something vibrates against the skin — like a lawnmower, a power tool, jogging, clapping, or even riding in a car — the body releases chemicals that cause swelling, redness, and itching in the area that was touched. This swelling is called angioedema, and in this condition it is specifically triggered by vibration. The condition is also sometimes called 'vibratory urticaria' because hives (urticaria) can appear alongside the swelling. The swelling usually happens within minutes of the vibration and

How is OBSOLETE: Vibratory angioedema inherited?

OBSOLETE: Vibratory angioedema follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.