Overview
Vibratory angioedema is a rare condition where the skin reacts to vibration by swelling up. When something vibrates against the skin — like a lawnmower, a power tool, jogging, clapping, or even riding in a car — the body releases chemicals that cause swelling, redness, and itching in the area that was touched. This swelling is called angioedema, and in this condition it is specifically triggered by vibration. The condition is also sometimes called 'vibratory urticaria' because hives (urticaria) can appear alongside the swelling. The swelling usually happens within minutes of the vibration and goes away on its own within about an hour. It most often affects the hands, arms, and other areas that come into direct contact with vibrating surfaces. In most cases the reaction stays local, but in some people it can cause more widespread symptoms like flushing, headache, or a general feeling of being unwell. It is worth noting that Orphanet has marked this condition as 'obsolete,' meaning it may now be classified under a broader category such as inducible urticaria or physical urticaria. Treatment usually involves antihistamines to reduce symptoms and avoiding vibration triggers as much as possible. The condition is not life-threatening in most cases, but it can significantly affect daily activities and quality of life.
Key symptoms:
Swelling of the skin after vibration exposureHives or raised red welts on the skinItching or burning where vibration touched the skinRedness of the skin in the affected areaFlushing or warmth spreading across the bodyHeadache after vibration exposureFeeling generally unwell or tired after a reactionSwelling that appears within minutes and fades within an hour
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Vibratory angioedema.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Vibratory angioedema.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Vibratory angioedema.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Should I carry an epinephrine auto-injector in case of a severe reaction?,Which antihistamine is best for me, and should I take it every day or only before exposure?,Is omalizumab (Xolair) an option for my level of symptoms?,Should other family members be tested or evaluated for this condition?,Are there any activities I absolutely must avoid, and which ones are safe with precautions?,How do I know if my reaction is becoming dangerous and when should I go to the emergency room?,Is there a specialist center or clinical trial I should know about?
Common questions about OBSOLETE: Vibratory angioedema
What is OBSOLETE: Vibratory angioedema?
Vibratory angioedema is a rare condition where the skin reacts to vibration by swelling up. When something vibrates against the skin — like a lawnmower, a power tool, jogging, clapping, or even riding in a car — the body releases chemicals that cause swelling, redness, and itching in the area that was touched. This swelling is called angioedema, and in this condition it is specifically triggered by vibration. The condition is also sometimes called 'vibratory urticaria' because hives (urticaria) can appear alongside the swelling. The swelling usually happens within minutes of the vibration and
How is OBSOLETE: Vibratory angioedema inherited?
OBSOLETE: Vibratory angioedema follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.