Overview
Trichodermal syndrome with intellectual disability (also sometimes referred to as tricho-dermo-vertebral syndrome or related names) is an extremely rare genetic condition that was historically described in medical literature but has since been classified as 'obsolete' in the Orphanet database, meaning it may have been reclassified, merged with another condition, or its original description may no longer be considered a distinct entity. The condition was originally reported to involve abnormalities of the hair (tricho-), skin (dermal), and intellectual development. Affected individuals were described as having unusual hair texture or growth patterns, skin abnormalities, and varying degrees of intellectual disability. Because this condition is obsolete in current classification systems, very limited up-to-date clinical information is available. Patients or families who were previously given this diagnosis should consult with a clinical geneticist to determine whether a more current diagnosis or reclassification applies to their situation. Modern genetic testing tools, such as whole exome or whole genome sequencing, may help clarify the underlying genetic cause and lead to a more precise diagnosis. Treatment has historically been supportive and symptom-based, addressing developmental delays through early intervention programs and managing any skin or hair-related concerns as they arise.
Also known as:
Key symptoms:
Intellectual disabilityUnusual hair texture or sparse hairSkin abnormalitiesDevelopmental delaysLearning difficulties
Childhood
Begins in childhood, roughly ages 1 to 12
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Trichodermal syndrome-intellectual disability syndrome.
View clinical trials →Clinical Trials
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Trichodermal syndrome-intellectual disability syndrome.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Trichodermal syndrome-intellectual disability syndrome.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is this diagnosis still considered valid, or should we pursue updated genetic testing for a more current diagnosis?,What genetic tests would you recommend to better understand my or my child's condition?,What early intervention services should we start right away?,Are there any related conditions we should be screened for?,How often should we follow up with specialists?,Are there any clinical trials or research studies that might be relevant?,What resources are available to support our family?
Common questions about OBSOLETE: Trichodermal syndrome-intellectual disability syndrome
What is OBSOLETE: Trichodermal syndrome-intellectual disability syndrome?
Trichodermal syndrome with intellectual disability (also sometimes referred to as tricho-dermo-vertebral syndrome or related names) is an extremely rare genetic condition that was historically described in medical literature but has since been classified as 'obsolete' in the Orphanet database, meaning it may have been reclassified, merged with another condition, or its original description may no longer be considered a distinct entity. The condition was originally reported to involve abnormalities of the hair (tricho-), skin (dermal), and intellectual development. Affected individuals were des
At what age does OBSOLETE: Trichodermal syndrome-intellectual disability syndrome typically begin?
Typical onset of OBSOLETE: Trichodermal syndrome-intellectual disability syndrome is childhood. Age of onset can vary across affected individuals.