Overview
This Orphanet entry (code 183601) is listed as 'OBSOLETE: Rare genetic refraction anomaly,' which means it is no longer an active or recognized classification in the Orphanet rare disease database. Refraction anomalies refer to problems with how the eye focuses light, such as nearsightedness (myopia), farsightedness (hyperopia), and astigmatism. In rare cases, these vision problems can have a strong genetic basis and may be unusually severe or appear as part of a broader genetic syndrome. Because this entry has been marked obsolete, the conditions it once described have likely been reclassified, merged into other disease entries, or are now categorized under more specific diagnoses. If you or a family member were previously given this diagnosis, it is important to speak with an ophthalmologist or clinical geneticist to determine the current, updated name and classification for your condition. An updated diagnosis can help you access the most relevant medical information, genetic testing, clinical trials, and support resources. Treatment for genetic refraction problems typically includes corrective lenses (glasses or contact lenses), and in some cases refractive surgery. If the refraction anomaly is part of a larger genetic syndrome, additional treatments may be needed depending on the other body systems involved.
Key symptoms:
Blurry visionDifficulty seeing objects up close or far awayEye strain or headachesSquinting to see clearlyDifficulty reading or doing close-up workProblems with night vision
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Rare genetic refraction anomaly.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for OBSOLETE: Rare genetic refraction anomaly at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Rare genetic refraction anomaly.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Rare genetic refraction anomaly.
Community
No community posts yet. Be the first to share your experience with OBSOLETE: Rare genetic refraction anomaly.
Start the conversation →Latest news about OBSOLETE: Rare genetic refraction anomaly
No recent news articles for OBSOLETE: Rare genetic refraction anomaly.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.This diagnosis is listed as obsolete — what is the current name or classification for my condition?,Is my refraction problem part of a larger genetic syndrome?,Should I or my family members have genetic testing?,How often should I have my eyes checked?,Are there any new treatments or clinical trials I should know about?,Will my vision likely get worse over time?,What can I do to protect my vision in daily life?
Common questions about OBSOLETE: Rare genetic refraction anomaly
What is OBSOLETE: Rare genetic refraction anomaly?
This Orphanet entry (code 183601) is listed as 'OBSOLETE: Rare genetic refraction anomaly,' which means it is no longer an active or recognized classification in the Orphanet rare disease database. Refraction anomalies refer to problems with how the eye focuses light, such as nearsightedness (myopia), farsightedness (hyperopia), and astigmatism. In rare cases, these vision problems can have a strong genetic basis and may be unusually severe or appear as part of a broader genetic syndrome. Because this entry has been marked obsolete, the conditions it once described have likely been reclassifi