Overview
This entry, listed under Orphanet code 98583, refers to a precancerous lesion of the skin (epidermis) of the eyelid (palpebral region). The term 'OBSOLETE' in the name means this classification is no longer actively used in current medical databases, as the condition has been reclassified or merged into broader categories of precancerous skin conditions. In simple terms, a precancerous lesion of the eyelid skin is an abnormal area of skin on or around the eyelid that has the potential to develop into skin cancer if left untreated. These lesions are most commonly caused by long-term sun exposure and ultraviolet (UV) radiation damage. The most typical form is called actinic keratosis, which appears as a rough, scaly patch on sun-exposed skin. When these patches occur on the eyelid, they require special attention because of the delicate nature of the eye area and the risk of progression to squamous cell carcinoma or other skin cancers. Treatment usually involves removal of the lesion through surgery, cryotherapy (freezing), or topical medications. Early detection and treatment are important to prevent progression to invasive cancer. Regular skin checks by a dermatologist or ophthalmologist are recommended for people at higher risk.
Key symptoms:
Rough or scaly patch on the eyelid skinPersistent redness on the eyelidA small bump or raised area on the eyelidCrusting or flaking skin on the eyelidA sore on the eyelid that does not healSkin thickening on the eyelidChange in color of eyelid skinItching or tenderness on the eyelidLoss of eyelashes in the affected areaA flat or slightly raised discolored patch
Multifactorial
Caused by a mix of several genes and environmental factors
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Precancerous lesion of palpebral epidermis.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for OBSOLETE: Precancerous lesion of palpebral epidermis at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Precancerous lesion of palpebral epidermis.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Precancerous lesion of palpebral epidermis.
Community
No community posts yet. Be the first to share your experience with OBSOLETE: Precancerous lesion of palpebral epidermis.
Start the conversation →Latest news about OBSOLETE: Precancerous lesion of palpebral epidermis
No recent news articles for OBSOLETE: Precancerous lesion of palpebral epidermis.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is this lesion precancerous, and what is the risk of it becoming cancer?,What treatment options are safest for a lesion on the eyelid?,How often should I have follow-up skin checks after treatment?,Are there specific sun protection measures I should take to prevent new lesions?,Should I see an oculoplastic surgeon for this lesion?,What signs should I watch for that would indicate the lesion is getting worse?,Could this condition affect my vision or eyelid function?
Common questions about OBSOLETE: Precancerous lesion of palpebral epidermis
What is OBSOLETE: Precancerous lesion of palpebral epidermis?
This entry, listed under Orphanet code 98583, refers to a precancerous lesion of the skin (epidermis) of the eyelid (palpebral region). The term 'OBSOLETE' in the name means this classification is no longer actively used in current medical databases, as the condition has been reclassified or merged into broader categories of precancerous skin conditions. In simple terms, a precancerous lesion of the eyelid skin is an abnormal area of skin on or around the eyelid that has the potential to develop into skin cancer if left untreated. These lesions are most commonly caused by long-term sun exposur
How is OBSOLETE: Precancerous lesion of palpebral epidermis inherited?
OBSOLETE: Precancerous lesion of palpebral epidermis follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: Precancerous lesion of palpebral epidermis typically begin?
Typical onset of OBSOLETE: Precancerous lesion of palpebral epidermis is adult. Age of onset can vary across affected individuals.