OBSOLETE: Precancerous lesion of palpebral epidermis

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ORPHA:98583
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8Treatment centers

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Overview

This entry, listed under Orphanet code 98583, refers to a precancerous lesion of the skin (epidermis) of the eyelid (palpebral region). The term 'OBSOLETE' in the name means this classification is no longer actively used in current medical databases, as the condition has been reclassified or merged into broader categories of precancerous skin conditions. In simple terms, a precancerous lesion of the eyelid skin is an abnormal area of skin on or around the eyelid that has the potential to develop into skin cancer if left untreated. These lesions are most commonly caused by long-term sun exposure and ultraviolet (UV) radiation damage. The most typical form is called actinic keratosis, which appears as a rough, scaly patch on sun-exposed skin. When these patches occur on the eyelid, they require special attention because of the delicate nature of the eye area and the risk of progression to squamous cell carcinoma or other skin cancers. Treatment usually involves removal of the lesion through surgery, cryotherapy (freezing), or topical medications. Early detection and treatment are important to prevent progression to invasive cancer. Regular skin checks by a dermatologist or ophthalmologist are recommended for people at higher risk.

Key symptoms:

Rough or scaly patch on the eyelid skinPersistent redness on the eyelidA small bump or raised area on the eyelidCrusting or flaking skin on the eyelidA sore on the eyelid that does not healSkin thickening on the eyelidChange in color of eyelid skinItching or tenderness on the eyelidLoss of eyelashes in the affected areaA flat or slightly raised discolored patch

Inheritance

Multifactorial

Caused by a mix of several genes and environmental factors

Age of Onset

Adult

Begins in adulthood (age 18 or older)

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for OBSOLETE: Precancerous lesion of palpebral epidermis.

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No actively recruiting trials found for OBSOLETE: Precancerous lesion of palpebral epidermis at this time.

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No specialists are currently listed for OBSOLETE: Precancerous lesion of palpebral epidermis.

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Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to OBSOLETE: Precancerous lesion of palpebral epidermis.

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Community

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Caregiver Resources

NORD Caregiver Resources

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Social Security Disability

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Questions for your doctor

Bring these to your next appointment

  • Q1.Is this lesion precancerous, and what is the risk of it becoming cancer?,What treatment options are safest for a lesion on the eyelid?,How often should I have follow-up skin checks after treatment?,Are there specific sun protection measures I should take to prevent new lesions?,Should I see an oculoplastic surgeon for this lesion?,What signs should I watch for that would indicate the lesion is getting worse?,Could this condition affect my vision or eyelid function?

Common questions about OBSOLETE: Precancerous lesion of palpebral epidermis

What is OBSOLETE: Precancerous lesion of palpebral epidermis?

This entry, listed under Orphanet code 98583, refers to a precancerous lesion of the skin (epidermis) of the eyelid (palpebral region). The term 'OBSOLETE' in the name means this classification is no longer actively used in current medical databases, as the condition has been reclassified or merged into broader categories of precancerous skin conditions. In simple terms, a precancerous lesion of the eyelid skin is an abnormal area of skin on or around the eyelid that has the potential to develop into skin cancer if left untreated. These lesions are most commonly caused by long-term sun exposur

How is OBSOLETE: Precancerous lesion of palpebral epidermis inherited?

OBSOLETE: Precancerous lesion of palpebral epidermis follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does OBSOLETE: Precancerous lesion of palpebral epidermis typically begin?

Typical onset of OBSOLETE: Precancerous lesion of palpebral epidermis is adult. Age of onset can vary across affected individuals.