Overview
Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies is a rare neurological condition in which the peripheral nerves — the nerves that connect the brain and spinal cord to the rest of the body — become damaged and inflamed. The term 'polyradiculoneuropathy' means that multiple nerve roots and peripheral nerves are affected at the same time. In this condition, the nerve damage is linked to the presence of an abnormal protein in the blood called a monoclonal gammopathy (an excess of one type of immunoglobulin — IgG, IgA, or IgM — produced by a single clone of immune cells). However, unlike some related conditions, the specific antibody target causing the nerve damage has not been identified. Please note that this entry is now classified as 'OBSOLETE' in Orphanet, meaning it may have been reclassified, merged with another disease entry, or its classification has been updated. Patients typically experience progressive weakness, numbness, and tingling in the arms and legs. The symptoms often start in the feet and hands and may gradually spread toward the trunk. Some people also notice pain, difficulty with balance, and reduced reflexes. The condition can significantly affect mobility and daily activities over time. Because the disease involves an immune-related process, treatments often focus on modifying the immune system's response. Options may include intravenous immunoglobulin (IVIg), plasma exchange (plasmapheresis), and corticosteroids. Treatment of the underlying monoclonal gammopathy, if needed, may also be considered. The course of the disease varies from person to person, and early diagnosis and treatment can help manage symptoms and slow progression.
Key symptoms:
Numbness or tingling in hands and feetProgressive muscle weakness in arms and legsDifficulty walking or maintaining balanceReduced or absent reflexesPain or burning sensations in the limbsFatigueDifficulty with fine motor tasks like buttoning clothesMuscle wasting over timeSensory loss (reduced ability to feel touch, temperature, or vibration)Unsteady gaitCramping in the legs or arms
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What type of monoclonal gammopathy do I have, and does it need separate treatment?,Which treatment option is best for my specific situation, and what are the potential side effects?,How often will I need treatment infusions or sessions?,Should I be monitored for progression of the monoclonal gammopathy to a blood cancer?,What can I do to maintain my strength and mobility at home?,Are there clinical trials available for my condition?,What signs of worsening should prompt me to seek urgent medical attention?
Common questions about OBSOLETE: Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies
What is OBSOLETE: Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies?
Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies is a rare neurological condition in which the peripheral nerves — the nerves that connect the brain and spinal cord to the rest of the body — become damaged and inflamed. The term 'polyradiculoneuropathy' means that multiple nerve roots and peripheral nerves are affected at the same time. In this condition, the nerve damage is linked to the presence of an abnormal protein in the blood called a monoclonal gammopathy (an excess of one type of immunoglobulin — IgG, IgA, or IgM — produced by a single
How is OBSOLETE: Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies inherited?
OBSOLETE: Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies typically begin?
Typical onset of OBSOLETE: Polyradiculoneuropathy associated with IgG/IgA/IgM monoclonal gammopathy without known antibodies is adult. Age of onset can vary across affected individuals.