OBSOLETE: Other muscle weakness and/or chronic muscle pain

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ORPHA:206606
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3Active trials8Treatment centers

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

This entry, listed under Orphanet code 206606, is classified as 'OBSOLETE' and was previously used to describe conditions involving muscle weakness and/or chronic muscle pain that did not fit neatly into other specific diagnostic categories. Because this classification is no longer actively used in current medical databases, it served more as a broad grouping term rather than a single well-defined disease. Patients who were once categorized under this label may have conditions such as chronic myalgia, non-specific myopathy, fibromyalgia, or other neuromuscular disorders that cause ongoing muscle weakness or pain. Muscle weakness can range from mild difficulty with everyday tasks like climbing stairs or lifting objects to more severe forms that affect walking or breathing. Chronic muscle pain may be constant or come and go, and it can significantly affect quality of life. Because this is an umbrella term rather than a specific diagnosis, the underlying cause varies widely from person to person. Some cases may be related to inflammatory conditions, metabolic problems, genetic neuromuscular diseases, or other systemic illnesses. If you or a loved one was previously given this classification, it is important to work with your medical team to obtain a more specific and up-to-date diagnosis. Modern genetic testing, advanced imaging, muscle biopsies, and blood tests can now identify many conditions that were previously grouped under broad categories like this one. A more precise diagnosis can open the door to targeted treatments and better management strategies.

Key symptoms:

Muscle weakness in arms or legsChronic muscle pain or achingFatigue or low energyDifficulty climbing stairsTrouble lifting objectsMuscle stiffnessMuscle crampsReduced exercise toleranceDifficulty with fine motor tasks like buttoning clothesGeneral body soreness

Inheritance

Variable

Can be inherited in different ways depending on the underlying gene

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

FDA & Trial Timeline

3 events
May 2025Effect of Occlusal Splint on Head and Neck Muscles in Patients With Bruxism and Myofascial Pain

Istanbul University — NA

TrialRECRUITING
Apr 2025Muscle Health Measurements Using Electrical Impedance Myography

Beth Israel Deaconess Medical Center

TrialRECRUITING
Sep 2024Treatment of Temporomandibular Disorders in Children and Adolsecents

Karolinska Institutet — NA

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for OBSOLETE: Other muscle weakness and/or chronic muscle pain.

3 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

3 recruitingView all trials with filters →
N/A2 trials
Effect of Occlusal Splint on Head and Neck Muscles in Patients With Bruxism and Myofascial Pain
N/A
Actively Recruiting
PI: berk bilgen, phd (Istanbul University) · Sites: Istanbul · Age: 1850 yrs
Treatment of Temporomandibular Disorders in Children and Adolsecents
N/A
Actively Recruiting
PI: Nikolaos Christidis, PhD (Karolinska Institutet, Department of Dental Medici) · Sites: Huddinge · Age: 713 yrs
Other1 trial
Muscle Health Measurements Using Electrical Impedance Myography
Actively Recruiting
PI: Pushpa Narayanaswami, M.D. (Beth Israel Deaconess Medical Center) · Sites: Boston, Massachusetts · Age: 1889 yrs

No specialists are currently listed for OBSOLETE: Other muscle weakness and/or chronic muscle pain.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to OBSOLETE: Other muscle weakness and/or chronic muscle pain.

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Community

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Caregiver Resources

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Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

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Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.Has a specific underlying cause for my muscle weakness or pain been identified, or do I need further testing?,Would genetic testing help clarify my diagnosis?,What type of physical therapy or exercise program would be safe and beneficial for me?,Are there any medications that could help manage my symptoms more effectively?,Should I be referred to a neuromuscular specialist or other subspecialist?,Are there any clinical trials or new treatments I should know about?,What warning signs should prompt me to seek emergency care?

Common questions about OBSOLETE: Other muscle weakness and/or chronic muscle pain

What is OBSOLETE: Other muscle weakness and/or chronic muscle pain?

This entry, listed under Orphanet code 206606, is classified as 'OBSOLETE' and was previously used to describe conditions involving muscle weakness and/or chronic muscle pain that did not fit neatly into other specific diagnostic categories. Because this classification is no longer actively used in current medical databases, it served more as a broad grouping term rather than a single well-defined disease. Patients who were once categorized under this label may have conditions such as chronic myalgia, non-specific myopathy, fibromyalgia, or other neuromuscular disorders that cause ongoing musc

Are there clinical trials for OBSOLETE: Other muscle weakness and/or chronic muscle pain?

Yes — 3 recruiting clinical trials are currently listed for OBSOLETE: Other muscle weakness and/or chronic muscle pain on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.